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...adiographic Scoring for the Degree of Defect Bridging and the Amount of Bone Formation in 15 and 20-mm Defects With and Without PLGA Implants Defect Bridging Bone Formation 15 mm No implant 2.4 6 1.6 =-=(4, 0, 1, 1, 2, 3, 4, 4)-=- 2.6 6 1.3 (4, 1, 1, 2, 2, 3, 4, 4) Implant 2 6 1.4 (1, 4, 1, 1, 1, 3, 4, 1) 2.4 6 1.2 (2, 4, 2, 2, 1, 3, 4, 1) 20 mm No implant 2.8 6 1.4 (4, 3, 3, 2, 4, 4, 0, 2) 3 6 1.2 (4, 4, 3, 2, 4, 4, 1, 2) Imp...

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...nd healing. INTRODUCTION The critical size defect (CSD) has been defined as the smallest intraosseous wound in an animal that will not heal spontaneously when left untreated for a certain time period =-=[1]-=- or which shows less than 10% bone regeneration during the lifetime of the animal [2]. The CSD has been used as an experimental model for evaluating the effectiveness of newly developed biomaterials [...