Spontaneous healing capacity of rabbit cranial

Abstract: Background: Although autogenous bone grafts are considered the gold standard for bone regeneration, they have certain limitations, including patient morbidity at the harvest site. Synthetic bone substitutes have been developed to overcome some of these limitations. The present study aimed to compare the osteogenic properties of Straumann Bone Ceramic (SBC), which is a biphasic calcium phosphate, with Bio-Oss, an inorganic bovine bone material, in an animal model. Methods: Thirteen rabbits were included in this study. In each rabbit, four 6.5-mm-diameter identical defects were prepared on the calvarium. One site was filled with Bio-Oss, the second site was treated with small-particle SBC, the third site was treated with large-particle SBC, and the fourth site was left as an untreated control. After 4 and 8 weeks, the animals were sacrificed, and histologic and histomorphometric examinations were performed. The data were analyzed using

Aim To study the demographics, comorbidities, clinical manifestations and treatment methods of thyroid eye disease (TED) in Singapore. Methods In this retrospective case series, we analysed the case records of all patients with TED who presented at our multidisciplinary Thyroid Eye Clinic from November 2002 to October 2012. Results There were a total of 174 patients—111 female patients (63.8%) and 63 male patients (36.2%). The majority of the patients were ethnically Chinese (80.5%), followed by Malay (10.3%) and Indian (6.3%). The mean age was 40.2 years (SD±15.5, range 0.3–87.0). The commonest sign on ophthalmic examination was eyelid retraction (62.1%), followed by

Compression and displacement of the developing fusion mass by the paraspinal musculature may be a contributory factor. Biocontainment devices have been clinically used in the skull and mandible to guide bone regeneration. The role of a mechanical device in containing graft material in the developing posterolateral lumbar spine fusion is unclear. PURPOSE: To determine the benefits of using a bioabsorbable graft-containment device for lumbar intertransverse fusion, and to evaluate the biocompatibility of this implant by histological analysis of the host tissue reaction. STUDY DESIGN: A rabbit intertransverse spine fusion model was used to evaluate a bioabsorb-able graft-containment implant. Study and control groups were compared with regard to the rate, volume, and quality of fusion, as well as host tissue reaction to the graft and implant. METHODS: Fourteen adult male New Zealand White rabbits underwent bilateral posterolateral intertransverse spine arthrodesis at L3–L4. The control group (n57) received autograft alone, and the study group received autografts placed in open meshed hemicylinders fashioned from Lac-toSorb sheets (LactoSorb; Biomet Orthopedics Inc., Warsaw, IN). Spines were harvested at 6 weeks and imaged. Radiographs and computed tomography (CT) images were used to calculate the rate,

st and implant surgeries. The autogenous bone is consid-ered as the gold standard because of its superior capacity used as bone graft materials [3]. Among Ca-Ps, HA, which is very stable, can maintain the space effectively but has