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... triplicate. Quantification of angiogenesis. Image analysis was performed on a Sun SPARC30 work station with the software Visilog 5.0 from Noesis. We used an improved computer-assisted image analysis =-=(3, 10)-=- that allows automatic measurements of the geometrical and morphological parameters. After generation of binary image, the following automatic measurements were obtained: the number of microvessels (N...

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...-1 exhibiting pro-sangiogenic effects and high concentrations acting in ansanti-angiogenic manner [37]. A similar dose-dependentseffect of PAI-1 on angiogenesis was observed in a studysby Devy et al. =-=[38]-=- that suggested that the increase insangiogenesis observed at physiological concentrations ofsPAI-1 is independent of its interactions with vitronectins[38]. From these studies and others, significant...

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... concentrations PAI-1 acted as pro-angiogenic, at highsconcentrations it was anti-angiogenic [233]. A similar dose-dependent effect of PAI-1 onsangiogenesis was also observed in a study by Devy et al =-=[261]-=-. In this study they showed that thesincrease in angiogenesis observed at physiological concentrations of PAI-1 was not dependent onsits ability to interact with VN [261].sTherefore a significant amou...

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...ne of the most informative biochemical markers of a poor prognosis in several human cancerstypes [2;3;9]. A dose-dependent effect of PAI-1 on pathological angiogenesis has beensobserved both in vitro =-=[10]-=- and in vivo [11-14]. Tumor growth and angiogenesis are impairedsin mice with a PAI-1 gene deletion [15-17] or following the induction of PAI-1 expression atssupraphysiological levels by adenoviral ge...

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...between PAI-1soverexpression in human tumors and a poor prognosis (Andreasen et al., 1997; Duffy, 2004).sA dose-dependent effect of PAI-1 on pathological angiogenesis has been observed both insvitro (=-=Devy et al., 2002-=-) and in vivo (Lambert et al., 2003; McMahon et al., 2001; Stefanssonset al., 2001; Bajou et al., 2004). Tumor growth and angiogenesis are impaired in mice with asPAI-1 gene deletion (Bajou et al., 19...

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...ne of the most informative biochemical markers of a poor prognosis in several human cancer types (2,3,9). A dose-dependent effect of PAI-1 on pathological angiogenesis has been observed both in vitro =-=(10)-=- and in vivo (11–14). Tumor growth and angiogenesis are impaired in mice with a PAI-1 gene deletion (15–17) or following the induction of PAI-1 expression at supraphysiological levels by adenoviral ge...

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...iai.asm .org/ D ow nloaded from The serpine PAI1 has been shown not only to be involved in regulation of fibrinolysis, cell adhesion, and cell migration (21) but also to exhibit angiogenic properties =-=(16)-=- and to inhibit the activation of the potent hepatocyte apoptogen and immunomodulatory Th2 cytokine latent transforming growth factor by plasminogen activators (20). The antiparasite effector functi...