Results 1 -
6 of
6
The CD14+ CD16+ blood monocytes: their role in infection and inflammation
- J. Leukoc. Biol
, 2007
"... Abstract: Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14 CD16 – and the CD14 CD16 monocytes. These cells have been shown to exhibit distinct phenotype and func-tion, and the CD14 CD16 were labeled proin-flammatory based on hig ..."
Abstract
-
Cited by 102 (0 self)
- Add to MetaCart
Abstract: Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14 CD16 – and the CD14 CD16 monocytes. These cells have been shown to exhibit distinct phenotype and func-tion, and the CD14 CD16 were labeled proin-flammatory based on higher expression of proin-flammatory cytokines and higher potency in anti-gen presentation. The current review describes these properties, including the relationship to den-dritic cells, and summarizes the host of publica-tions about CD14 CD16 monocytes in inflam-mation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease. J. Leukoc.
unknown title
"... Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells ..."
Abstract
- Add to MetaCart
(Show Context)
Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells
The FASEB Journal • Research Communication Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function
"... ABSTRACT At present, �150 different members of the adhesion-G protein-coupled receptor (GPCR) family have been identified in metazoans. Surprisingly, very little is known about their function, although they all possess large extracellular domains coupled to a seventransmembrane domain, suggesting a ..."
Abstract
- Add to MetaCart
(Show Context)
ABSTRACT At present, �150 different members of the adhesion-G protein-coupled receptor (GPCR) family have been identified in metazoans. Surprisingly, very little is known about their function, although they all possess large extracellular domains coupled to a seventransmembrane domain, suggesting a potential role in cell adhesion and signaling. Here, we demonstrate how the human-restricted adhesion-GPCR, EMR2 (epidermal growth factor-like module-containing mucin-like hormone receptor), regulates neutrophil responses by potentiating the effects of a number of proinflammatory mediators and show that the transmembrane region is critical for adhesion-GPCR function. Using an anti-EMR2 antibody, ligation of EMR2 increases neutrophil adhesion and migration, and augments superoxide
The FASEB Journal • FJ Express Full-Length Article An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2
"... ABSTRACT The epidermal growth factor (EGF)- ..."
(Show Context)
References Subscriptions Permissions Email Alerts The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense
, 2013
"... This article cites 51 articles, 24 of which you can access for free at: ..."
(Show Context)
