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...llular stores. This may be suggestive of a physical association between Ly-6G and integrins on the cell surface, as has been demonstrated for three other GPI-linked proteins: uPAR, CD14, and Fc�RIIIB =-=[48]-=-. Although this up-regulation could plausibly explain the neutrophil depletion, microvascular disturbances, and death detected in mice subjected to Ly-6G cross-linking, experiments, where the effect o...

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...Similar to GPI-80, GPI-anchored proteins such as urokinase-type plasminogen-activator receptor (uPAR, CD87), Fc�RIIIb (CD16b), and CD14, regulate the functions of � 2 integrins on neutrophil surfaces =-=[9]-=-. Cross-linking neutrophil surface uPAR or Fc�RIIIb by their antibodies induces an increase in the expression of CD11b on the surfaces of the cells [10, 11]. In this study, we examined whether cross-l...

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...in the GPI-80-mediated sequential up- and down-regulation of � 2-integrin-dependent neutrophil functions. A GPI-induced modulation of the avidity of the � 2integrin for its ligands has been suggested =-=[24]-=-, and this gains support from the fact that another GPI-anchored protein (UPAR) has been shown to be of importance for leukocyte recruitment via the � 2-integrin [25]. It is worth noting that UPAR is ...

Citation Context

...llular stores. This may be suggestive of a physical association between Ly-6G and integrins on the cell surface, as has been demonstrated for three other GPI-linked proteins: uPAR, CD14, and Fc�RIIIB =-=[48]-=-. Although this up-regulation could plausibly explain the neutrophil depletion, microvascular disturbances, and death detected in mice subjected to Ly-6G cross-linking, experiments, where the effect o...