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by Kenneth R. Feingold, Ilona Staprans, Riaz A. Memon, Arthur H. Moser, Judy K, William Doerrler, Charles A. Dinarello, Carl Grunfeld
"... Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance ..."
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Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance
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by B E Henricson, C L Manthey, P Y Perera, T A Hamilton , 1992
"... versus monophosphoryl lipid A. macrophages pretreated with smooth LPS (LPS)-inducible gene expression in murine Dissociation of lipopolysaccharide ..."
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versus monophosphoryl lipid A. macrophages pretreated with smooth LPS (LPS)-inducible gene expression in murine Dissociation of lipopolysaccharide

NOTES Roles of Interleukin-1 and Tumor Necrosis Factor in

by S N Vogel, B E Henricson, R Neta, Lipopolysaccharide-induced Hypoglycemia, Stefanie N. Vogel, Beth E. Henricson, Ruth Neta , 1991
"... hypoglycemia. factor in lipopolysaccharide-induced Roles of interleukin-1 and tumor necrosis ..."
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hypoglycemia. factor in lipopolysaccharide-induced Roles of interleukin-1 and tumor necrosis
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by H D Danenberg, G Alpert, S Lustig, D Ben-nathan , 1992
"... factor production. endotoxin toxicity and reduces tumor necrosis Dehydroepiandrosterone protects mice from ..."
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factor production. endotoxin toxicity and reduces tumor necrosis Dehydroepiandrosterone protects mice from
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Hypoglycemia, and Cytokine Release in D-Galactosamine-Sensitized and Unsensitized Mice

by Staphylococcal Enterotoxin, B-induced Weight Loss, Patrick Matthys, Tania Mitera, Hubertine Heremans, Jo Van Damme, Alfons Billiau , 1995
"... Administration of staphylococcal enterotoxin B (SEB) to BALB/c mice was found to induce a cytokine release syndrome hallmarked by weight loss and hypoglycemia. A neutralizing monoclonal antibody against gamma interferon (IFN-g) given before SEB counteracted weight loss and prevented hypoglycemia. Th ..."
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Administration of staphylococcal enterotoxin B (SEB) to BALB/c mice was found to induce a cytokine release syndrome hallmarked by weight loss and hypoglycemia. A neutralizing monoclonal antibody against gamma interferon (IFN-g) given before SEB counteracted weight loss and prevented hypoglycemia. This protective effect of anti-IFN-g antibody was associated with decreased IFN-g levels in serum; tumor necrosis factor (TNF) and interleukin-6 (IL-6) levels remained unchanged. A monoclonal anti-IL-6 antibody, known for its ability to cause accumulation of biologically active IL-6 in the circulation, did not modify SEB-induced body weight loss or hypoglycemia. Levels of TNF, IFN-g, and IL-6 in serum were all more elevated in anti-IL-6-treated mice than in corresponding SEB-challenged control mice. In D-galactosamine-sensitized mice, SEB-induced weight loss but not hypoglycemia was more severe, resulting mostly in death within 24 h. Higher levels of biologically active TNF and IFN-g in serum were noted in these mice than in mice receiving SEB only. In D-galactosamine-sensitized mice, anti-IFN-g antibody did prevent hypoglycemia but failed to reduce the severity of the syn-drome. Again, TNF levels in anti-IFN-g-treated mice remained unchanged. Pretreatment with anti-IL-6 antibody temporarily attenuated SEB-induced hypoglycemia in sensitized mice. Thus, at 6 h post-SEB injec-tion, anti-IL-6-treated mice were less hypoglycemic than corresponding controls. However, at 24 h, hypogly-cemia was significantly aggravated. Concomitantly, IL-6 levels were dramatically increased. Neither anti-IFN-g
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