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We discuss external and internal graphical and linguistic representational systems. We argue that a cognitive theory of peoples' reasoning performance must account for (a) the logical equivalence of inferences expressed in graphical and linguistic form; and (b) the implementational differences that affect facility of inference. Our theory proposes that graphical representations limit abstraction and thereby aid processibility. We discuss the ideas of specificity and abstraction, and their cognitive relevance. Empirical support comes from tasks involving (i) the manipulation of external graphics; and (ii) no external graphics. For (i), we take Euler's Circles, provide a novel computational reconstruction, show how it captures abstractions, and contrast it with earlier construals, and with Mental Models' representations. We demonstrate equivalence of the graphical Euler system, and the non-graphical Mental Models system. For (ii), we discuss text comprehension, and the mental ...

Work in philosophy and psychology has argued for a dissociation between perceptuallybased similarity and higher-level rules in conceptual thought. Although such a dissociation may be justified at times, our goal is to illustrate ways in which conceptual processing is grounded in perception, both for perceptual similarity and abstract rules. We discuss the advantages, power and influences of perceptually-based representations. First, many of the properties associated with amodal symbol systems can be achieved with perceptually-based systems as well (e.g. productivity). Second, relatively raw perceptual representations are powerful because they can implicitly represent properties in an analog fashion. Third, perception naturally provides impressions of overall similarity, exactly the type of similarity useful for establishing many common categories. Fourth, perceptual similarity is not static but becomes tuned over time to conceptual demands. Fifth, the original motivation or basis for sophisticated cognition is often less sophisticated perceptual similarity. Sixth, perceptual simulation occurs even in conceptual tasks that have no explicit perceptual demands. Parallels between perceptual and conceptual processes suggest that many mechanisms typically associated

The agent-based approach emphasizes the importance of learning through organism-environment interaction. This approach is part of a recent trend in computational models of learning and development toward studying autonomous organisms that are embedded in virtual or real environments. In this paper we introduce the concepts of online and offline sampling and highlight the role of online sampling in agent-based models. After comparing the strengths of each approach for modeling particular developmental phenomena and research questions, we describe a recent agent-based model of infant causal perception. We conclude by discussing some of the present limitations of agent-based models and suggesting how these challenges may be addressed. © 2001 Academic Press Computational models of learning and development are playing an increasingly critical role in child development research (Cassidy, 1990;

This paper reports and extends discussions carried out during a workshop held at the Santa Fe Institute in August 1995 by the authors. It treats eight major topics: (i) the importance of carefully examining research on routine, (it) the concept of 'action patterns ' in general and in terms of routine, (Hi) the useful categorization of routines and other recurring patterns, (iv) the research implications of recent cognitive results, (v) the relation of evolution to action patterns, (vi) the contributions of simulation modeling for theory in this area, (vii) examples of various approaches to empirical jj; research that reveal key problems, and (viii) a possible definition of 'routine'. An m extended appendix by Massimo Egidi provides a lexicon of synonyms and opposites ji covering use of the word 'routine ' in such areas as economics, organization theory and z artificial intelligence. 6

Dunker K., et al Proteins can exist in a trinity of structures: the ordered state, the molten globule and the random coil. Five examples follow which suggest that native protein structure can correspond to any of the three states (not just the ordered state) and that protein function can arise from any of the three states and their transitions. 1. In a process that likely mimics infection, fd phage converts from the ordered into the disordered molten globular state. 2. Nucleosome hyperacetylation is crucial to DNA replication and transcription; this chemical modification greatly increases the net negative charge of the nucleosome core particle. We propose that the increased charge imbalance promotes its conversion to a much less rigid form. 3. Clusterin contains an ordered domain and also a native molten globular region. The molten globular domain likely functions as a proteinaceous detergent for cell remodeling and removal of apoptotic debris. 4. In a critical signaling event, a helix in calcineurin becomes bound and surrounded by calmodulin, thereby

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A continuum between purely isolated and purely interrelated concepts is described. A concept is interrelated to the extent that it is influenced by other concepts. Methods for manipulating and identiying a concept's degree of interrelatedness are introduced. Relatively isolated concepts are empirically identified by a relatively large use of nondiagnostic features, and by better categorization performance for a concept's prototype than for a caricature of the concept. Relatively interrelated concepts are identified by minimal use of nondiagnostic features, and by better categorization performance for a caricature than a prototype. A concept is likely to be relatively isolated when: subjects are instructed to create images for their concepts rather than find discriminating features, concepts are given unrelated labels, and the categories that are displayed alternate rarely between trials. The entire set of manipulations and measurements supports a graded distinction between isolated and interrelated concepts. The distinction is applied to current models of category learning, and a connectionist framework for interpreting the empirical results is presented. Modern research on concept representation and learning has evolved from two traditions. One tradition connects concept acquisition with language in general and word learning in specific (Lakoff, 1986; Saussure, 1915/1959). Concepts are approximately equated with single words or phrases. In this tradition, for example, evidence that a child has acquired the adult concept of dog comes from the child's use of the word "dog" to designate dogs. The other tradition connects concept acquisition with object recognition (Biederman, 1987). From this perspective, concept learning involves learning to correctly cate...

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Neural network predictors of protein disorder using primary sequence information were developed and applied to the Swiss Protein Database. More than 15,000 proteins were predicted to contain disordered regions of at least 40 consecutive amino acids, with more than 1,000 having especially high scores indicating disorder. These results support proposals that consideration of structure-activity relationships in proteins need to be broadened to include unfolded or disordered protein.