Results 1 -
6 of
6
Attentional influences on the dynamics of motion-induced blindness
- J. Vis. 9
, 2009
"... Motion-induced blindness (MIB) is a visual phenomenon in which a highly salient, peripheral, visual target spontaneously disappears from visual awareness (and subsequently reappears) when superimposed on a globally moving background of distracters. Here, we investigated the influence of attention o ..."
Abstract
-
Cited by 3 (0 self)
- Add to MetaCart
Motion-induced blindness (MIB) is a visual phenomenon in which a highly salient, peripheral, visual target spontaneously disappears from visual awareness (and subsequently reappears) when superimposed on a globally moving background of distracters. Here, we investigated the influence of attention on these fluctuations in perception in two experiments. In the first experiment, directing spatial attention to the MIB target (and thus away from the distracters) led to an increased probability of disappearance of the target. This counter-intuitive effect of attention enhancing disappearance is nonetheless consistent with earlier reports that increased target salience enhances disappearance. Conversely, in a second experiment withdrawing attention from the entire MIB display (both target and distracters) led to a decrease in perceptual disappearances and reappearances, as well as prolonged periods of invisibility. Taken together these findings suggest that the global availability of attention facilitates competition between target and moving distracters, while the local direction of attention toward or away from the target can influence the outcome of that competition. Thus, in common with other related perceptual phenomena, attention has complex effects on the dynamics of target-distracter interactions associated with motion-induced blindness.
HUMAN NEUROSCIENCE Original Research Article
, 2011
"... The advantage of ambiguity? Enhanced neural responses to multi-stable percepts correlate with the degree of perceived instability ..."
Abstract
- Add to MetaCart
(Show Context)
The advantage of ambiguity? Enhanced neural responses to multi-stable percepts correlate with the degree of perceived instability
Reviewed by:
, 2013
"... †Erica Lynn Bradshaw-Pierce and Todd M. Pitts have contributed equally to this work. P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overex-pressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis o ..."
Abstract
- Add to MetaCart
(Show Context)
†Erica Lynn Bradshaw-Pierce and Todd M. Pitts have contributed equally to this work. P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overex-pressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel p-21 activated kinase inhibitor, efficacy was influenced by tumor P-gp. Based on in vitro proliferation data, a panel of colorectal cancer cell lines were ranked as sensitive or resistant and ABCB1 (P-gp) expression was evaluated by microarray for these cell lines. P-gp expression was determined by western blot and activity deter-mined by rhodamine efflux assay. Knock down of P-gp and pharmacologic inhibition of P-gp to restore PF-309 activity was performed in vitro. PF-309 activity was evaluated in vivo in cell line xenograft models and in primary patient derived tumor xenografts (PDTX). Mice were treated with 25 mg/kg PF-309 orally, twice daily. On the last day of treatment, tumor and plasma were collected for PF-309 analysis. Here we show that ABCB1 gene expres-
Reviewed by:
, 2015
"... Spatially specific vs. unspecific disruption of visual orientation perception using chronometric pre-stimulus ..."
Abstract
- Add to MetaCart
(Show Context)
Spatially specific vs. unspecific disruption of visual orientation perception using chronometric pre-stimulus
Review Article The Human Frontal Lobes and Frontal Network Systems: An Evolutionary, Clinical, and Treatment Perspective
"... which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Frontal lobe syndromes, better termed as frontal network systems, are relatively unique in that they may manifest from almost any brain region, due to their widespread connecti ..."
Abstract
- Add to MetaCart
(Show Context)
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Frontal lobe syndromes, better termed as frontal network systems, are relatively unique in that they may manifest from almost any brain region, due to their widespread connectivity. The understandings of the manifold expressions seen clinically are helped by considering evolutionary origins, the contribution of the state-dependent ascending monoaminergic neurotransmitter systems, and cerebral connectivity. Hence, the so-called networktopathies may be a better term for the syndromes encountered clinically. An increasing array ofmetric tests are becoming available that complement that long standing history of qualitative bedside assessments pioneered by Alexander Luria, for example. An understanding of the vast panoply of frontal systems ’ syndromes has been pivotal in understanding and diagnosing the most common dementia syndrome under the age of 60, for example, frontotemporal lobe degeneration. New treatment options are also progressively becoming available, with recent evidence of dopaminergic augmentation, for example, being helpful in traumatic brain injury. The latter include not only psychopharmacological options but also device-based therapies including mirror visual feedback therapy. 1. Definition and Synonyms Clinically, frontal lobe syndromes, frontal network syn-dromes, frontal systems syndromes, executive dysfunction, and metacognition have all been used to describe disorders
