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Could Sensory Mechanisms Be a Core Factor That Underlies Freezing of Gait in Parkinson’s Disease?
, 2012
"... The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater ..."
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The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater the occurrence of freezing of gait. Nineteen patients with Parkinsoǹs disease who experience freezing of gait (PD-FOG) walked through a doorway or into open space in complete darkness. The three doorway conditions included: (i) FRAME (DARK) – walking through the remembered door frame; (ii) FRAME- walking through the door with the door frame illuminated; (iii) FRAME+BODY- walking through the door (both the door and the limbs illuminated). Additionally, two conditions of walking away from the doorway included: (iv) NO FRAME (DARK)- walking into open space; (v) NO FRAME+BODY- walking into open space with the limbs illuminated, to evaluate whether perception (or fear) of the doorway might account for FOG behaviour. Key outcome measures included: the number of freezing of gait episodes recorded, total duration of freezing of gait, and the percentage of time spent frozen. Significantly more freezing of gait episodes occurred when participants walked toward the doorway in complete darkness compared to walking into open space (p,0.05). Similar to previous studies, velocity (p,0.001) and step length (p,0.0001) significantly decreased when walking through the door in complete darkness, compared to all other conditions. Significant increases in step width variability were also identified but only when walking into open space (p,0.005). These
Contents lists available at ScienceDirect Developmental Cognitive Neuroscience
"... Neural mirroring systems: Exploring the EEG mu rhythm in ..."
doi: 10.1152/jn.00905.2012
, 2013
"... gravitational balance constraints during step preparation Cortical facilitation of proprioceptive inputs related to You might find this additional info useful... 56 articles, 8 of which you can access for free at: This article cites ..."
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gravitational balance constraints during step preparation Cortical facilitation of proprioceptive inputs related to You might find this additional info useful... 56 articles, 8 of which you can access for free at: This article cites
The authors thank the Natural Sciences and
, 2014
"... doi: 10.1002/phy2.267 A multitude of events bombard our sensory systems at every moment of our lives. Thus, it is important for the sensory cortex to gate unimportant events. Tactile suppression is a well-known phenomenon defined as a reduced ability to detect tactile events on the skin before and d ..."
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doi: 10.1002/phy2.267 A multitude of events bombard our sensory systems at every moment of our lives. Thus, it is important for the sensory cortex to gate unimportant events. Tactile suppression is a well-known phenomenon defined as a reduced ability to detect tactile events on the skin before and during movement. Previous experiments found detection rates decrease just prior to and during finger abduction, and decrease according to the proximity of the moving effector. This study examined how tactile detection changes during a reach to grasp. Fourteen human participants used their right hand to reach and grasp a cylin-der. Tactors were attached to the index finger, the fifth digit, and the forearm of both the right and left arm and vibrated at various epochs relative to a “go ” tone. Results showed that detection rates at the forearm decreased before movement onset; whereas at the right index finger, right fifth digit and at the left index finger, left fifth digit, and forearm sites did not decrease like in the right forearm. These results indicate that the task affects gating dynamics in a temporally- and contextually dependent manner and implies that feed-forward motor planning processes can modify sensory signals.