We present a method, called opportunistic scheduling, for exploiting the time-varying nature of the radio environment to increase the overall performance of the system under certain quality of service/fairness requirements of users. We first introduce a general framework for opportunistic scheduling, and then identify three general categories of scheduling problems under this framework. We provide optimal solutions for each of these scheduling problems. All the proposed scheduling policies are implementable online; we provide parameter estimation algorithms and implementation procedures for them. We also show how previous work by us and others directly fits into or is related to this framework. We demonstrate via simulation that opportunistic scheduling schemes result in significant performance improvement compared with non-opportunistic alternatives.