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Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ. Health Perspect (2007)

by V H Grassian, P T O’Shaughnessy, A Adamcakova-Dodd, J M Pettibone, P S Thorne
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The implications of accession

by Hong Li , 2000
"... Proteomic analysis of effluents from perfused human heart for transplantation: identification of potential biomarkers for ischemic heart damage ..."
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Proteomic analysis of effluents from perfused human heart for transplantation: identification of potential biomarkers for ischemic heart damage

711th Human Performance Wing

by Saber M. Hussain, Laura K. Braydich-stolle, Janice L. Speshock, Kyung O. Yu, Amanda M. Schrand, Christin M. Grabinski, Nicole M. Schaeublin, Richard C. Murdock, Alicia B. Castle, Michael C. Moulton, Elizabeth I. Maurer, Cataleya Nmi Carlson, Samantha J. Kunzelman, Krista L. Hess, Rochelle L. Jones , 2007
"... Approved for public release; Distribution unlimited. NOTICE Using Government drawings, specifications, or other data included in this document for any purpose other than Government procurement does not in any way obligate the U.S. Government. The fact that the Government formulated or supplied the d ..."
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Approved for public release; Distribution unlimited. NOTICE Using Government drawings, specifications, or other data included in this document for any purpose other than Government procurement does not in any way obligate the U.S. Government. The fact that the Government formulated or supplied the drawings, specifications, or other data does not license the holder or any other person or corporation; or convey any rights or permission to manufacture, use, or sell any patented invention that

ENGINEERED METAL BASED NANOMATERIALS IN AQUEOUS ENVIRONMENTS: INTERACTIONS, TRANSFORMATIONS AND IMPLICATIONS

by Imali Ama Mudunkotuwa, Imali Ama Mudunkotuwa
"... Engineered metal based nanomaterials in aqueous environments: interactions, transformations and implications ..."
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Engineered metal based nanomaterials in aqueous environments: interactions, transformations and implications

Review Article Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of In Vivo Studies

by Ivo Iavicoli, Veruscka Leso, Antonio Bergamaschi , 2012
"... Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The essence of nanotechnology is the production of nanoparticles (NPs) with unique physicochemical properties allowing worldwide applicati ..."
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Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The essence of nanotechnology is the production of nanoparticles (NPs) with unique physicochemical properties allowing worldwide application in new structures, materials, and devices. The consequently increasing human exposure to NPs has raised concerns regarding their health and safety profiles. Titanium dioxide (TiO2) has been reported to induce adverse pulmonary responses in exposed animals. However, the potential more dangerous biological activities of TiO2 NPs compared to their fine-sized counterparts are not fully understood. Therefore, this work is aimed to provide a comprehensive evaluation of the toxic effects induced by TiO2 NPs in in vivo experiments. It is intended to deeply understand the toxicological behaviour of TiO2 NPs and to predict potential human health effects. Moreover, it may be an instrument to extrapolate relevant data for human risk evaluation andmanagement and to identify those critical aspects that deserve great attention in future population and epidemiologic research. 1.

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by unknown authors
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by Matikainen S, Alenius H
"... 1 Airway exposure to silica coated TiO2 nanoparticles induces pulmonary neutrophilia in mice. ..."
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1 Airway exposure to silica coated TiO2 nanoparticles induces pulmonary neutrophilia in mice.
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...ous studies have reported pulmonary neutrophilia after exposure to TiO2snanoparticles whereas others have reported negative results in inhalation experimentss(Hextset al. 2005) (Warheit et al. 1996) (=-=Grassian et al. 2007-=-) (Oberdörster 2001) (Geiser et al.s2008). Insufficient or complete lack of characterization of nanoparticles in those studiessmakes comparison to present study very difficult.sTo further investigate ...

Advance Access publication October 29, 2009 Airway Exposure to Silica-Coated TiO2 Nanoparticles Induces Pulmonary Neutrophilia in Mice

by Kai Savolainen, Sampsa Matikainen, Harri Alenius , 2009
"... The importance of nanotechnologies and engineered nano-particles has grown rapidly. It is therefore crucial to acquire up-to-date knowledge of the possible harmful health effects of these materials. Since a multitude of different types of nanosized titanium dioxide (TiO2) particles are used in indus ..."
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The importance of nanotechnologies and engineered nano-particles has grown rapidly. It is therefore crucial to acquire up-to-date knowledge of the possible harmful health effects of these materials. Since a multitude of different types of nanosized titanium dioxide (TiO2) particles are used in industry, we explored their inflammatory potential using mouse and cell models. BALB/c mice were exposed by inhalation for 2 h, 2 h on 4 consecutive days, or 2 h on 4 consecutive days for 4 weeks to several commercial TiO2 nanoparticles, SiO2 nanoparticles, and to nanosized TiO2 generated in a gas-to-particle conversion

Addressing Potential Health Risks from Nanomaterials......................................................................................... 1

by Amber R. Wise, Jackie Schwartz, Tracey J. Woodruff, George Alexeeff, Cal Epa
"... 1.3 Unique Properties of Nanoparticles—Why size matters................................................................................. 9 1.4 Current and projected applications of nanotechnology in California, the United ..."
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1.3 Unique Properties of Nanoparticles—Why size matters................................................................................. 9 1.4 Current and projected applications of nanotechnology in California, the United
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...re more Hu et al. 2009 [102] Zn, Cu, Al, La, Fe, Sn and Ti. toxic, identity of metal less important Whole animal Mice TiO2 aerosols Subacute exposure showed inflammatory response Grassian et al. 2007 =-=[105]-=- human, pig & rat skin, living/attached, and model systems Various rodents, inhalation & injection Rat, inhalation and injection TiO2and ZnO TiO2 MnO, Fe2O3 Insoluble nanoparticles of TiO2 & ZnO do no...

Science Advisory Panel

by Amber R. Wise, Jackie Schwartz, Tracey J. Woodruff, David Warheit Dupont-haskell
"... We would like to thank the following: ..."
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We would like to thank the following:
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...t generally penetrate healthysskin.sNohynek et al. 2007s[127] (review,scontains manysreferences)sWhole animalsMice TiO2 aerosols Subacute exposure showedsinflammatory response.sGrassian et al. 2007s=-=[128]-=-sVarious rodents,sinhalation and injectionsTiO2 Inhalation studies showed increasedslung tumors; injection studies did notsshow tumors.sIARC, summary andsevaluation of TiO2,s[129]sRats, inhalation a...

unknown title

by unknown authors
"... Abstract—Sustainability, being the urgent issue of our time, is closely related with the innovations in technology. Nanotechnology (NT), although not a new science, can be regarded relatively a new science for buildings with brand new materials and applications. This paper tends to give a research r ..."
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Abstract—Sustainability, being the urgent issue of our time, is closely related with the innovations in technology. Nanotechnology (NT), although not a new science, can be regarded relatively a new science for buildings with brand new materials and applications. This paper tends to give a research review of current and near future applications of nanotechnology (NT) for achieving high-performance and healthy buildings for a sustainable future. In the introduction, the driving forces for the sustainability of construction industry are explained. Then, the term NT is defined, and significance of innovations in NT for a sustainable construction industry is revealed. After presenting the application areas of NT and nanomaterials for buildings with a number of cases, challenges in the adoption of this technology are put forward, and finally the impacts of nanoparticles and nanomaterials on human health and environment are discussed. Keywords—Nanomaterial, self-healing concrete, self-cleaning sensor, nano sensor, steel, wood, aerogel, flexible solar panel. I.
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...ration of reactive oxygen species that exertsoxidative stress (e.g. TiO2), release of toxic heavy metals orsother components, and direct oxidation upon contact with cellsconstituents. Grassian et al. =-=[48]-=- studied the effects related tosthe inhalation of TiO2 particles with a primary particle sizesbetween 2 and 5 nm, reporting lung inflammation. Ultra-finesSiO2 nanoparticles also have been reported as ...

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