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Amino acid changes in proteins 2B and 3A mediate rhinovirus type 39 growth in mouse cells
- J
, 2005
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Cited by 7 (1 self)
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These include: This article cites 80 articles, 56 of which can be accessed free at:
Evidence for Functional Protein Interactions Required for Poliovirus RNA Replication
, 2005
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Age-dependent poliovirus replication in the mouse central nervous system is determined by internal ribosome entry site-mediated translation
- J
, 2006
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Cited by 1 (0 self)
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This article cites 3 articles, 3 of which can be accessed free at:
Adaptation of an ICAM-1-Tropic Enterovirus to the Mouse Respiratory Tract
, 2010
"... Respiratory tract (RT) infections by members of the enterovirus (EV) genus of the Picornaviridae family are the most frequent cause for the common cold and a major factor in the exacerbation of chronic pulmonary diseases. The lack of a practical small-animal model for these infections has obstructed ..."
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Respiratory tract (RT) infections by members of the enterovirus (EV) genus of the Picornaviridae family are the most frequent cause for the common cold and a major factor in the exacerbation of chronic pulmonary diseases. The lack of a practical small-animal model for these infections has obstructed insight into pathogenic mechanisms of the common cold and their role in chronic RT illness and has hampered preclinical evaluation of antiviral strategies. Despite significant efforts, it has been difficult to devise rodent models that exhibit viral replication in the RT. This is due mainly to well-known intracellular host restrictions of EVs with RT tropism in rodent cells. We report the evolution of variants of the common-cold-causing coxsackievirus A21, an EV with tropism for the human intercellular adhesion molecule 1 (hICAM-1), through serial passage in the lungs of mice transgenic for the hICAM-1 gene. This process was accompanied by multiple changes in the viral genome, suggesting exquisite adaptation of hICAM-1-tropic enteroviruses to the specific growth conditions within the RT. In vivo mouse RT-adapted, variant coxsackievirus A21 exhibited replication competence in the lungs of hICAM-1 transgenic mice, providing a basis for unraveling EV-host interactions in the mouse RT. The common cold (acute nasopharyngitis) is a frequent ail-ment, primarily of viral etiology, recognized since antiquity. The incidence in adults and children ranges from 2 to 4 and 6
doi:10.1093/nar/gkq1258 Directed adenovirus evolution using engineered mutator
, 2010
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Correspondence
, 2003
"... Mouse respiratory epithelial cells support efficient replication of human rhinovirus ..."
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Mouse respiratory epithelial cells support efficient replication of human rhinovirus
CONTENT ALERTS
, 2007
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