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Results 1 - 10
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14,466
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies
- J Cell Biol
"... Abstract. The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently being developed for suppression of tum ..."
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Cited by 34 (4 self)
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Abstract. The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently being developed for suppression
The Plasminogen Activator Inhibitor PAI-1 Controls In Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies
"... Desiré Collen, Peter Carmeliet, ..."
Vascular permeability factor (vascular endothelial growth factor gene is expressed differentially in normal tissues, macrophages and tumors
- MA BiA Cell. 3:211
, 1992
"... Persistent microvascular hyperpermeability to plasma proteins even after the cessation of injury is a characteristic but poorly understood feature of normal wound healing. It results in extravasation of fibrinogen that clots to form fibrin, which serves as a provisional matrix and promotes angiogene ..."
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Cited by 367 (9 self)
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angiogenesis and scar formation. We present evidence indicating that vascular permeability factor (VPF; also known as vascular endothelial growth factor) may be responsible for the hyperpermeable state, as well as the angiogenesis, that are characteristic of healing wounds. Hyperpermeable blood vessels were
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
- J Clin Oncol
"... The expression of vascular endothelial growth factor (VEGF) by breast tumors has been previously correlated with a poor prognosis in the pathogenesis of breast cancer. Furthermore, VEGF secretion is a prerequisite for tumor development. Although most of the effects of VEGF have been shown to be attr ..."
Abstract
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Cited by 118 (0 self)
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The expression of vascular endothelial growth factor (VEGF) by breast tumors has been previously correlated with a poor prognosis in the pathogenesis of breast cancer. Furthermore, VEGF secretion is a prerequisite for tumor development. Although most of the effects of VEGF have been shown
TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION*
, 1972
"... The continued growth of solid neoplasms is always associated with neovascularization. A possible mediator is tumorangiogenesis factor (TAF), an endothelial cell mitogen which has been extracted from a variety of solid malignant tumors, in this laboratory (1). The specific blockade of this factor, &q ..."
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Cited by 24 (1 self)
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not vascularize, failed to grow for almost 2 yr. However, when these same tumors were reimplanted into their original host, they vascularized and grew progressively. These observations suggested that a fundamental relationship might exist between angiogenesis and the ability of a tumor to grow malignantly. The
Epithelial and Mesenchymal Tumor Compartments Exhibit In Vivo Complementary Patterns of Vascular Perfusion
"... Glucose transport and consumption are increased in tumors, and this is considered a diagnostic index of malignancy. However, there is recent evidence that carcinoma-associated stromal cells are capable of aero-bic metabolism with low glucose consumption, at least partly because of their efficient va ..."
Abstract
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Cited by 1 (0 self)
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vascular supply. In the present study, using dynamic contrast-enhanced magnetic resonance imaging and [F-18]fluorodeoxyglu-cose (FDG) positron emission tomography (PET), we mapped in vivo the vascular supply and glucose metab-olism in syngeneic experimental models of carcinoma and mesenchymal tumor. We
Up- regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis
- Cancer Res
, 1993
"... Capillary hemangioblastoma is the most frequent manifestation of the autosomal dominantly inherited von Hippel-Lindau (VHL) disease but also presents as a nonfamilial, sporadic vascular tumor. Hemangioblasto mas are characterized by a dense network of capillaries in association with cysts. To invest ..."
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Cited by 58 (2 self)
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Capillary hemangioblastoma is the most frequent manifestation of the autosomal dominantly inherited von Hippel-Lindau (VHL) disease but also presents as a nonfamilial, sporadic vascular tumor. Hemangioblasto mas are characterized by a dense network of capillaries in association with cysts
Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate.
- Clin Cancer Res
, 2004
"... ABSTRACT Purpose: Green tea consumption has been linked to a reduced occurrence of some tumor types. Current data indicate that the principal mediator of this chemopreventive effect is epigallocatechin-3-gallate (EGCG), the most abundant polyphenol found in dried tea leaves. Here, we examined the e ..."
Abstract
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Cited by 9 (1 self)
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the effects of this compound on the two key cell populations typically involved in tumor growth: tumor cells and endothelial cells. Experimental Design: The effects of green tea and EGCG were tested in a highly vascular Kaposi's sarcoma (KS) tumor model and on endothelial cells in a panel of in vivo
Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors
- Blood
, 2000
"... Emerging data suggest that a subset of circulating human CD341 cells have phe-notypic features of endothelial cells. Whether these cells are sloughed mature endothelial cells or functional circulating endothelial precursors (CEPs) is not known. Using monoclonal antibodies (MoAbs) to the extracellula ..."
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Cited by 147 (5 self)
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Abs) to the extracellular domain of the human vascular endothelial recep-tor-2 (VEGFR-2), we have shown that 1.2 6 0.3 % of CD341 cells isolated from fetal liver (FL), 2 6 0.5 % from mobilized peripheral blood, and 1.4 6 0.5 % from cord blood were VEGFR-21. In addition, most CD341VEGFR-21 cells express he-matopoietic stem
VASCULAR BIOLOGY Netrin-4 induces lymphangiogenesis in vivo
"... Netrin-4, a laminin-related secreted pro-tein is an axon guidance cue recently shown essential outside of the nervous system, regulating mammary and lung morphogenesis as well as blood vascular development. Here, we show that Netrin-4, at physiologic doses, induces proliferation, migration, adhesion ..."
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not suppress Netrin-4–promoted in vitro effects. In vivo, Netrin-4 induces growth of lymphatic and blood vessels in the skin of transgenic mice and in breast tumors. Its overexpression in human and mouse mammary carcinoma cancer cells leads to enhanced metastasis. Finally, Netrin-4 stimulates in vitro
Results 1 - 10
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14,466
