Results 1 - 10 of 3,847

COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance

by Ruslan Sadreyev, Nick Grishin, Howard Hughes Medical - J. Mol. Biol , 2003
"... We present a novel method for the comparison of multiple protein align-ments with assessment of statistical significance (COMPASS). The method derives numerical profiles from alignments, constructs optimal local profile–profile alignments and analytically estimates E-values for the detected similari ..."
Abstract - Cited by 125 (33 self) - Add to MetaCart
with high sig-nificance are similarities between various Rossmann-type folds and between various helix-turn-helix-containing families. The potential value of COMPASS for structure/function predictions is illustrated by the detec-tion of an intricate homology between the DNA-binding domain of the CTF

The Vocabulary Problem in Human-System Communication

by G. W. Furnas, T. K. Landauer, L. M. Gomez, S. T. Dumais - COMMUNICATIONS OF THE ACM , 1987
"... In almost all computer applications, users must enter correct words for the desired objects or actions. For success without extensive training, or in first-tries for new targets, the system must recognize terms that will be chosen spontaneously. We studied spontaneous word choice for objects in five ..."
Abstract - Cited by 562 (8 self) - Add to MetaCart
in five application-related domains, and found the variability to be surprisingly large. In every case two people favored the same term with probability <0.20. Simulations show how this fundamental property of language limits the success of various design methodologies for vocabulary-driven interaction

Prior distributions for variance parameters in hierarchical models

by Andrew Gelman - Bayesian Analysis , 2006
"... Various noninformative prior distributions have been suggested for scale parameters in hierarchical models. We construct a new folded-noncentral-t family of conditionally conjugate priors for hierarchical standard deviation parameters, and then consider noninformative and weakly informative priors i ..."
Abstract - Cited by 430 (15 self) - Add to MetaCart
Various noninformative prior distributions have been suggested for scale parameters in hierarchical models. We construct a new folded-noncentral-t family of conditionally conjugate priors for hierarchical standard deviation parameters, and then consider noninformative and weakly informative priors

Transactional Locking II

by Dave Dice, Ori Shalev, Nir Shavit - In Proc. of the 20th Intl. Symp. on Distributed Computing , 2006
"... Abstract. The transactional memory programming paradigm is gaining momentum as the approach of choice for replacing locks in concurrent programming. This paper introduces the transactional locking II (TL2) algorithm, a software transactional memory (STM) algorithm based on a combination of commit-ti ..."
Abstract - Cited by 359 (17 self) - Add to MetaCart
better than) that of all former STM algorithms, both lock-based and non-blocking. Perhaps more importantly, on various benchmarks, TL2 delivers performance that is competitive with the best hand-crafted fine-grained concurrent structures. Specifically, it is ten-fold faster than a single lock. We believe

Reevaluating Amdahl’s law

by John L. Gustafson - Commun. ACM , 1988
"... At Sandia National Laboratories, we are currently en-gaged in research involving massively parallel process-ing. There is considerable skepticism regarding the via-bility of massive parallelism; the skepticism centers around Amdahl’s law, an argument put forth by Gene Amda.hl in 1967 [l] that even w ..."
Abstract - Cited by 316 (4 self) - Add to MetaCart
that very few problems will experience even a loo-fold speedup. Yet, for three very practical applications (s = 0.4-0.8 percent) used at Sandia, we have achieved speedup factors on a 1024-processor hy-percube that we believe are unprecedented [2]: 2022 for beam stress analysis using conjugate gradients

A spatio-temporal descriptor based on 3d-gradients

by Alexander Kläser, Marcin Marszałek, Cordelia Schmid - In BMVC’08
"... In this work, we present a novel local descriptor for video sequences. The proposed descriptor is based on histograms of oriented 3D spatio-temporal gradients. Our contribution is four-fold. (i) To compute 3D gradients for arbitrary scales, we develop a memory-efficient algorithm based on integral v ..."
Abstract - Cited by 234 (6 self) - Add to MetaCart
In this work, we present a novel local descriptor for video sequences. The proposed descriptor is based on histograms of oriented 3D spatio-temporal gradients. Our contribution is four-fold. (i) To compute 3D gradients for arbitrary scales, we develop a memory-efficient algorithm based on integral

Robust rate adaptation for 802.11 wireless networks

by Starsky H. Y. Wong, Hao Yang, Songwu Lu, Vaduvur Bharghavan - in ACM Mobicom , 2006
"... Rate adaptation is a mechanism unspecified by the 802.11 standards, yet critical to the system performance by exploiting the multi-rate capability at the physical layer. In this paper, we conduct a systematic and experimental study on rate adaptation over 802.11 wireless networks. Our main contribut ..."
Abstract - Cited by 191 (3 self) - Add to MetaCart
contributions are two-fold. First, we critique five design guidelines adopted by most existing algorithms. Our study reveals that these seemingly correct guidelines can be misleading in practice, thus incur significant performance penalty in certain scenarios. The fundamental challenge is that rate adaptation

Automatically parcellating the human cerebral cortex.

by Bruce Fischl , André Van Der Kouwe , Christophe Destrieux , Eric Halgren , Florent Ségonne , David H Salat , Evelina Busa , Larry J Seidman , Jill Goldstein , David Kennedy , Verne Caviness , Nikos Makris , Bruce Rosen , Anders M Dale , Bruce Fischl - Cereb. Cortex , 2004
"... Abstract -We present a technique for automatically assigning a neuroanatomical label to each location on a cortical surface model based on probabilistic information estimated from Introduction Techniques for labeling geometric features of the cerebral cortex are useful for analyzing a variety of fu ..."
Abstract - Cited by 189 (14 self) - Add to MetaCart
fold in the precentral gyrus Various approaches have been taken to the problem of labeling of cortical features. For example, Sandor and Leahy (Sandor and Leahy, 1997) use a manually labeled atlas brain, which is then warped into correspondence with an individual subject's surface model

Prevalence of quadruplexes in the human genome

by Shankar Balasubramanian - Nucleic Acids Res , 2005
"... Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded structures called G-quadruplexes. In this paper, we present a working rule to predict which primary sequences can form this structure, and describe a search algo-rithm to identify such sequences in genomic DN ..."
Abstract - Cited by 168 (6 self) - Add to MetaCart
Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded structures called G-quadruplexes. In this paper, we present a working rule to predict which primary sequences can form this structure, and describe a search algo-rithm to identify such sequences in genomic

On linear variational surface deformation methods

by Mario Botsch, Olga Sorkine
"... This survey reviews the recent advances in linear variational mesh deformation techniques. These methods were developed for editing detailed high-resolution meshes, like those produced by scanning real-world objects. The challenge of manipulating such complex surfaces is three-fold: the deformatio ..."
Abstract - Cited by 169 (11 self) - Add to MetaCart
This survey reviews the recent advances in linear variational mesh deformation techniques. These methods were developed for editing detailed high-resolution meshes, like those produced by scanning real-world objects. The challenge of manipulating such complex surfaces is three-fold
Results 1 - 10 of 3,847