Results 1 - 10 of 328

Expression of Urokinase-Type Plasminogen Activator (u-PA), u-PA Receptor, and

by Daniela Tavian, Ro Copeta, Et Al, Cancer Res, Contact The Aacr Publications, Tissue-type Pa, Messenger Rnas, Human Hepatocellular Carcinoma, Daniela Tavian, Ro Copeta, Nazario Portolani, Stefano Maria Giulini, Sergio Barlati
"... Expression of plasminogen activators (PAs) and urokinase-type PA receptor (u-PAR) is associated with tumor growth and invasion. For in vivo human tumor tissues, there is no information on gene expression of PAs in hepatocellular carcinoma (HCC) or other hepatic pathophysiological conditions. In this ..."
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Expression of plasminogen activators (PAs) and urokinase-type PA receptor (u-PAR) is associated with tumor growth and invasion. For in vivo human tumor tissues, there is no information on gene expression of PAs in hepatocellular carcinoma (HCC) or other hepatic pathophysiological conditions

Mini-Review Urokinase-Type Plasminogen Activator: Proenzyme, Receptor, and Inhibitors

by Francesco Blasi, Jean-dominique Vassalli, Keld Dan
"... 'Ew information has recently become available that we believe may be of value for a more precise focusing of research on the role of plasminogen activators (PAs) in cellular physiology and pathology. PAs convert the abundant extracellular zymogen plasminogen into plasmin, an active protease tha ..."
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that, directly or indirectly, can promote degradation of all components of the extracellular matrix. The urokinase-type PA (u-PA) is one of two activators with similar catalytic specificities that have been described in each mammalian species so far studied. Many cell types synthesize and secrete u-PA

Mice Deficient in Urokinase-Type Plasminogen Activator Have Delayed Healing of Tympanic Membrane

by unknown authors , 2012
"... Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing. The activation of plasminogen to plasmin is performed by two plasminogen activators (PAs), urokinase-type P ..."
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Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing. The activation of plasminogen to plasmin is performed by two plasminogen activators (PAs), urokinase-type

Increased secretion of urokinase-type plasminogen

by Hisanaga Yagyu, Takeshi Matsuoka
"... Increased secretion of urokinase-type plasminogen activator by human lung microvascular endothelial cells. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L47–L54, 1998.—Human lung microvascular endothelial cells (HLMECs) secreted 1.5– 15 times more urokinase-type plasminogen activator (uPA) anti ..."
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Increased secretion of urokinase-type plasminogen activator by human lung microvascular endothelial cells. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L47–L54, 1998.—Human lung microvascular endothelial cells (HLMECs) secreted 1.5– 15 times more urokinase-type plasminogen activator (uPA

The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies

by Khalid Bajou, Véronique Masson, Robert D. Gerard, Petra M. Schmitt, Valérie Albert, Michael Praus, Leif R. Lund, Thomas L. Fr, Nils Brunner, Keld Dano, Norbert E. Fusenig, Ulrich Weidle, Geert Carmeliet, David Loskutoff, Desiré Collen, Peter Carmeliet, Jean Michel Foidart, Agnès Noël - J Cell Biol
"... Abstract. The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently being developed for suppression of tum ..."
Abstract - Cited by 34 (4 self) - Add to MetaCart
Abstract. The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently being developed for suppression

Tissue Factor-Like Procoagulant and Urokinase-Type

by Cells Human, Myelomonocytic Line, Rc-a Synthesize, Plasminogen Activator, L. Saravo, H. Helm
"... Cells of the myelomonocytic leukemia cell line RC-2A were studied for their ability to synthesize clotting-promoting and fibrinolytic factors. The cells were observed to gen-erate procoagulant activity (PCA) in readily measurable quantities. Incubation of RC-2A cells with phorbol myristate acetate ( ..."
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macrophages. Stimulation of the cells with lectins (PHA, concanavalin A) or PMA was followed by a modest (2-3-fold) increase In PA. Enzyme immunoassay with antibodies to urokinase (u-PA) or tissue-type PA (t-PA) identif led the RC-2A plasminogen activator as being of urokinase type. Key words: monocyte

Mutations affecting the activity of urokinase-type plasminogen activator

by Lance S. Davidow, Dennis R. Dumais, Adrienne P. Smyth, Jonathan Greer, Donald T. Moir
"... 'To whom correspondence should be addressed Mutagenesis throughout the single-chain urokinase-type plasminogen activator (scu-PA) cDNA molecule, followed by expression of the mutant genes and secretion of the resulting mutant proteins from yeast, has been used to determine the amino acid residu ..."
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'To whom correspondence should be addressed Mutagenesis throughout the single-chain urokinase-type plasminogen activator (scu-PA) cDNA molecule, followed by expression of the mutant genes and secretion of the resulting mutant proteins from yeast, has been used to determine the amino acid

Plasmin-dependent and-independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis

by Jill Norman, Michael S. Goligorsky, Jun Chen, Albert Lee, Akassoglou Jill Norman , 2001
"... Plasmin-dependent and-independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. Am J Physiol Heart Circ Physiol 281: H1784–H1792, 2001.— Plasminogen activator (PA) inhibitor-1 (PAI-1) has been rec-ognized as a surrogate marker of endothelial dysfunction in diseases assoc ..."
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associated with impaired angiogenesis, including atherosclerosis, diabetic vasculopathy, and nephropathy. To establish the necessary and sufficient components of the PA system [PAI-1, urokinase-type PA (uPA), or tissue-type PA (tPA), and plasminogen (Plg)] for angiogenesis, we examined angiogenic competence

Prognostic value of urokinase-type plasminogen activator (uPA) and

by C. Bouchet
"... Summary It is now clearly established that proteolytic enzymes, including plasminogen activator (uPA), play an important role in breaking down the extracellular matrix, which is considered to be a step in metastasis formation. Plasminogen activators are controlled at various levels. Two inhibitors, ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
Summary It is now clearly established that proteolytic enzymes, including plasminogen activator (uPA), play an important role in breaking down the extracellular matrix, which is considered to be a step in metastasis formation. Plasminogen activators are controlled at various levels. Two inhibitors

ARTICLES Modulation of Plasminogen Activator Systems by Matrix Components in Two

by Breast Cancer, Cell Lines Mcf, Natalie Pourreau-schneider, Pierre Delori, Brigitte Boutiere, Dominique Arnoux, Francois George, Jose Sampol, Pierre Marie Martin
"... We have analyzed the plasminogen activator (PA) systems of two metastatic breast adenocarcinoma cell lines, MCF-7 and MDA-MB-231, as a function of 17/3-estradiol stimu-lation when the cells were cultured on purified components of extracellular matrix. Laminin enhanced PA levels in both cell lines, b ..."
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, but this enhancement seemed to occur via different mechanisms, including dissociation of inhibitor complexes. The major effect was the marked increase in cell-associated urokinase-type PA (u-PA); the increase was independent of estrogen in hormone-insensitive MDA-MB-231 cells grown on laminin-coated surfaces
Results 1 - 10 of 328