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UniProt: the Universal Protein Knowledgebase

by Rolf Apweiler, Amos Bairoch, Cathy H. Wu, Winona C. Barker, Brigitte Boeckmann, Serenella Ferro, Elisabeth Gasteiger, Hongzhan Huang, Rodrigo Lopez, Michele Magrane, Maria J. Martin, Darren A. Natale, Claire O'Donovan, Nicole Redaschi, Lai-Su L. Yeh - NUCLEIC ACIDS RES , 2004
"... To provide the scientific community with a single, centralized, authoritative resource for protein sequences and functional information, the Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt) consortium. Our mission is to provide ..."
Abstract - Cited by 335 (27 self) - Add to MetaCart
To provide the scientific community with a single, centralized, authoritative resource for protein sequences and functional information, the Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt) consortium. Our mission is to provide

The swiss-prot protein knowledgebase and its supplement trembl in 2003

by Brigitte Boeckmann, Amos Bairoch, Rolf Apweiler, Marie-claude Blatter, Anne Estreicher, Elisabeth Gasteiger, Maria J. Martin, Karine Michoud, Isabelle Phan, Rine Pilbout, Michel Schneider - Nucleic Acids Res , 2003
"... The SWISS-PROT protein knowledgebase ..."
Abstract - Cited by 748 (15 self) - Add to MetaCart
The SWISS-PROT protein knowledgebase

The KEGG resource for deciphering the genome

by Minoru Kanehisa, Susumu Goto, Shuichi Kawashima, Yasushi Okuno, Masahiro Hattori - Nucleic Acids Res , 2004
"... A grand challenge in the post-genomic era is a complete computer representation of the cell and the organism, which will enable computational prediction of higher-level complexity of cellular processes and organism behavior from genomic information. Toward this end we have been developing a knowledg ..."
Abstract - Cited by 513 (24 self) - Add to MetaCart
knowledge-based approach for network prediction, which is to predict, given a complete set of genes in the genome, the protein interaction networks that are responsible for various cellular processes. KEGG at

Knowledge-based protein secondary structure assignment

by Dmitrij Frishman, Patrick Argos - Proteins , 1995
"... ABSTRACT We have developed an auto-matic algorithm STRIDE for protein secondary structure assignment from atomic coordinates based on the combined use of hydrogen bond energy and statistically derived backbone tor-sional angle information. Parameters of the pattern recognition procedure were optimiz ..."
Abstract - Cited by 324 (2 self) - Add to MetaCart
ABSTRACT We have developed an auto-matic algorithm STRIDE for protein secondary structure assignment from atomic coordinates based on the combined use of hydrogen bond energy and statistically derived backbone tor-sional angle information. Parameters of the pattern recognition procedure were

The Universal Protein Resource (UniProt): an expanding universe of protein information

by Cathy H. Wu, Rolf Apweiler, Amos Bairoch, Darren A. Natale, Winona C. Barker, Brigitte Boeckmann, Serenella Ferro, Elisabeth Gasteiger, Hongzhan Huang, Rodrigo Lopez, Michele Magrane, Maria J. Martin, Raja Mazumder, Nicole Redaschi, Baris Suzek - Nucleic Acids Res , 2006
"... The Universal Protein Resource (UniProt) provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. The UniProt Knowledgebase (UniProtKB), compris-ing the manually annotated UniProtKB/Swiss-Prot sec ..."
Abstract - Cited by 302 (20 self) - Add to MetaCart
The Universal Protein Resource (UniProt) provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. The UniProt Knowledgebase (UniProtKB), compris-ing the manually annotated Uni

An evolutionary trace method defines binding surfaces common to protein families

by Olivier Lichtarge, Henry R. Bourne, Fred E. Cohen - J. Mol. Biol , 1996
"... 1Departments of Cellular and X-ray or NMR structures of proteins are often derived without their Molecular Pharmacology and ligands, and even when the structure of a full complex is available, the area Medicine and of contact that is functionally and energetically significant may be a 2Department of ..."
Abstract - Cited by 355 (31 self) - Add to MetaCart
of Pharmaceutical Chemistry specialized subset of the geometric interface deduced from the spatial University of California proximity between ligands. Thus, even after a structure is solved, it San Francisco remains a major theoretical and experimental goal to localize protein

The Triple Helix---University-Industry-Government Relations: A Laboratory for Knowledge-Based Economic Development

by Loet Leydesdorff - EASST Review , 1995
"... Government Relations (cf. Etzkowitz & Leydesdorff, 1995; Lowe, 1982) into a model for studying knowledge-based economies. A series of workshops, conferences, and special issues of journals have developed under this title since 1996. In various countries, the Triple Helix concept ..."
Abstract - Cited by 209 (19 self) - Add to MetaCart
Government Relations (cf. Etzkowitz & Leydesdorff, 1995; Lowe, 1982) into a model for studying knowledge-based economies. A series of workshops, conferences, and special issues of journals have developed under this title since 1996. In various countries, the Triple Helix concept

Touring protein fold space with DALI/FSSP

by Liisa Holm, Chris S - Nucleic Acids Res , 1998
"... The FSSP database and its new supplement, the Dali Domain Dictionary, present a continuously updated classification of all known 3D protein structures. The classification is derived using an automatic structure alignment program (Dali) for the all-against-all comparison of structures in the Protein ..."
Abstract - Cited by 188 (0 self) - Add to MetaCart
/FSSP organization of protein structures provides a map of the currently known regions of the protein universe that is useful for the analysis of folding principles, for the evolutionary unification of protein families and for maximizing the information return from experimental structure determination.

Activities at the universal protein resource (uniprot

by The Uniprot Consortium - Nucleic Acids Research , 2014
"... The mission of the Universal Protein Resource (UniProt) ..."
Abstract - Cited by 121 (0 self) - Add to MetaCart
The mission of the Universal Protein Resource (UniProt)

The Sorcerer II Global Ocean Sampling expedition: Expanding the universe of protein families. PLoS Biol 5: e16

by Shibu Yooseph, Granger Sutton, Douglas B. Rusch, Aaron L. Halpern, Shannon J. Williamson, Karin Remington, Jonathan A. Eisen, Karla B. Heidelberg, Gerard Manning, Weizhong Li, Lukasz Jaroszewski, Piotr Cieplak, Christopher S. Miller, Huiying Li, Susan T. Mashiyama, Marcin P. Joachimiak, Christopher Van Belle, John-marc Ch, David A. Soergel, Yufeng Zhai, Kannan Natarajan, Shaun Lee, Benjamin J. Raphael, Vineet Bafna, Robert Friedman, Steven E. Brenner, Adam Godzik, David Eisenberg, Jack E. Dixon, Susan S. Taylor, Robert L. Strausberg, Marvin Frazier, J. Craig Venter , 2007
"... Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins predic ..."
Abstract - Cited by 151 (6 self) - Add to MetaCart
Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins
Results 1 - 10 of 4,723