problems yielding fresh and possibly unexpected insights. This is

Unexpected insights for anti-EGFR cancer therapy

of some unexpected trigonometric formulae based on regular polygons. The original “voyage ” has been changed only sufficiently to make the text readable.

, measurements of seismic anisotropy potentially allow insights to physical systems which would otherwise lie outside current seismic imaging capabilities.

The search for molecules that restrict synaptic plasticity in the brain has focused primarily on sensory systems during early postnatal development, as critical periods for inducing plasticity in sensory regions are easily defined. The recent discovery that Schaffer collateral inputs to hippocampal area CA2 do not readily support canonical activity-dependent long-term po-tentiation (LTP) serves as a reminder that the capacity for synaptic modification is also regulated anatomically across dif-ferent brain regions. Hippocampal CA2 shares features with other similarly “LTP-resistant ” brain areas in that many of the genes linked to synaptic function and the associated proteins known to restrict synaptic plasticity are expressed there. Add to this a rich complement of receptors and signaling molecules permissive for induction of atypical forms of synaptic po-tentiation, and area CA2 becomes an ideal model system for studying specific modulators of brain plasticity. Additionally, recent evidence suggests that hippocampal CA2 is instrumental for certain forms of learning, memory, and social behavior, but the links between CA2-enriched molecules and putative CA2-dependent behaviors are only just beginning to be made. In this review, we offer a detailed look at what is currently known about the synaptic plasticity in this important, yet largely overlooked component of the hippocampus and consider how the study of CA2 may provide clues to understanding the molecular signals critical to the modulation of synaptic function in different brain regions and across different stages of development. Synaptic plasticity during postnatal brain development is critical

This article deals only with what might be called the geometrization of combinatorics. Namely, the idea that viewing combinatorial objects from a geometric perspective often yields unexpected insights. Even more concretely, we concentrate on finite metric spaces and their embeddings

study several parameters of b-suffix trees, namely: the depth of a given suffix, the depth of insertion, the height and the shortest feasible path. Some new results concerning typical (i.e., almost sure) behaviors of these parameters are established. These findings are used to obtain several insights

, and critically detect when these expectancies are violated, even when task demands do not require it. The present study also offers broader insights into the nature of essential computations carried out by the hippocampus, which may also underpin its unique contribution to episodic memory.

-making practices. Unfortunately, methods for gaining insight into unexpected simulation outcomes have not kept pace. SMEs need to understand and explain unexpected behaviors in exploratory simulations to determine if the behaviors reflect an error or if they represent new knowledge in the discipline. Common

Managing the unexpected is relevant for all organizations and banks experienced this bitterly during the financial crisis of 2007-2009. In this study we argue that the organizational mindset driving unexpected results within the banking sector stemmed from an inability to anticipate and detect