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58,875
Tumor cell migration in complex microenvironments
- Cell Mol Life Sci
"... Tumor cell migration is essential for invasion and dissemination from primary solid tumors and for the establishment of lethal secondary metastases at distant organs. In vivo and in vitro models enabled identification of different factors in the tumor microenvironment that regulate tumor progression ..."
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Cited by 2 (0 self)
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Tumor cell migration is essential for invasion and dissemination from primary solid tumors and for the establishment of lethal secondary metastases at distant organs. In vivo and in vitro models enabled identification of different factors in the tumor microenvironment that regulate tumor
Thrombospondininduced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains
- J. Cell
, 1987
"... Abstract. Thrombospondin induces the migration of human melanoma and carcinoma cells. Using a modified Boyden chamber assay, tumor cells migrated to a gradient of soluble thrombospondin (chemotaxis). Checkerboard analysis indicated that directional migration was induced 27-fold greater than stimulat ..."
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Cited by 20 (3 self)
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Abstract. Thrombospondin induces the migration of human melanoma and carcinoma cells. Using a modified Boyden chamber assay, tumor cells migrated to a gradient of soluble thrombospondin (chemotaxis). Checkerboard analysis indicated that directional migration was induced 27-fold greater than
Id1 Promotes Tumor Cell Migration in Nonsmall Cell Lung Cancers
"... Id1, which belongs to the Id family of helix-loop-helix transcription factors has been most associated with tumor progression and metastatsis; however, its significance in lung cancers has not been extensively explored. Here we seek to evaluate the expression of Id1 in a pilot study of nonsmall-cel ..."
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performed to evaluate the role of Id1 in tumor cell growth, migration and progression. We find Id1 expression is upregulated in squamous cell carcinoma when compared to adenocarcinoma of the lung and that expression of Id1 versus the normal control is variable in NSCLCs. We also note that Id1 expression
Human Tumor Cell Migration 1,2
"... SUMMARY-Cell suspensions from a variety of human tumors were tested for their capacity for active movement in a capillary tube migra-tion assay. A proportion of Burkitt's lymphoma biopsy specimens and tissue culture lines were motile, as were leukemic cells from the peripheral blood of patients ..."
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SUMMARY-Cell suspensions from a variety of human tumors were tested for their capacity for active movement in a capillary tube migra-tion assay. A proportion of Burkitt's lymphoma biopsy specimens and tissue culture lines were motile, as were leukemic cells from the peripheral blood
Research Article Id1 Promotes Tumor Cell Migration in
"... Copyright © 2010 Raka Bhattacharya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Id1, which belongs to the Id family of heli ..."
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dependant and constitutive expression of Id1 in NSCLC cells significantly increases tumor cell migration without affecting cell proliferation. We conclude that Id1, as a mediator of tumor cell migration, may be an indicator of aggressive potential in nonsmall-cell lung cancers. 1.
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
- Cancer Res
, 2004
"... Invasion of tumor cells into the surrounding connective tissue and blood vessels is a key step in the metastatic spread of breast tumors. Although the presence of macrophages in primary tumors is associated with increased metastatic potential, the mechanistic basis for this observation is unknown. U ..."
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Cited by 71 (6 self)
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. Using a chemotaxis-based in vivo invasion assay and multiphoton-based intravital imaging, we show that the interaction between macrophages and tumor cells facilitates the migration of carcinoma cells in the primary tumor. Gradients of either epidermal growth factor (EGF) or colony-stimulating factor 1
breast tumor cell migration and invasion through ERK and AKT signaling
"... Chemokine receptor signaling has a prominent role in breast cancer cell migration in the context of metastasis formation, but the roles of many receptor-ligand pairs in this process remain unclear. Here we determined the expression profile of chemokine receptors and their respective ligands in the m ..."
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down of CXCR3 in MTLn3 cells inhibited cell migration into an artificial wound which was associated with reduced protrusion formation. Together, these data suggest that autocrine CXCR3 activation is important for MTLn3 tumor cell migration and invasion and a potentially important drug target to inhibit
CD44H regulates tumor cell migration on hyaluronate-coated substrate
- J. Cell
, 1992
"... Abstract. CIM4 is a broadly distributed cell surface glycoprotein expressed in different isoforms in various tissues and cell lines. One of two recently characterized human isoforms, CIM4H, is a cell surface receptor for hyalumnate, suggesting a role in the regulation of cell-cell and cell-substrate ..."
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Cited by 37 (6 self)
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-substrate interactions as well as of cell migration. While CD44H has been shown to mediate cell adhesion, direct demonstration that CD44H expression promotes cell motility has been lacking. In this work we show that a human melanoma cell line, stably transfected with CIM4H, displays enhanced motility on hyaluronate
Results 1 - 10
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58,875
