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Tumor Angiogenesis
, 1846
"... A tumor consists of a rapidly dividing and growing population of cells that have lost their ability to divide in a controlled fash-ion. Once a tumor lesion exceeds a few millimeters in diam-eter, hypoxia and nutrient deprivation trigger an angiogenic switch that allows the tumor to receive oxygen an ..."
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process called tumor angiogenesis, as well as a recruitment of new tumor-associated cells such as macrophages and fibroblasts.2–4 Both tumor cells and tumor-associated cells contribute to the vascularization by activating and recruiting endothelial cells within blood vessels that are close to the tumor
The role of PTEN in tumor angiogenesis.
- J Oncol
, 2012
"... During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pat ..."
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During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase
Editorial Tumor Angiogenesis 2012
, 2012
"... License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. It has been more than 40 years since the initial prospect emerged that tumor angiogenesis could be targeted for cancer therapy. This proposal was based on the very sim ..."
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License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. It has been more than 40 years since the initial prospect emerged that tumor angiogenesis could be targeted for cancer therapy. This proposal was based on the very
Radionuclide Imaging of Tumor Angiogenesis
"... Angiogenesis is a multistep process regulated by pro- and antiangiogenic factors. In order to grow and me-tastasize, tumors need a constant supply of oxygen and nutrients. For growth beyond 1–2 mm in size, tumors are dependent on angiogenesis. Inhibition of angiogenesis is a new cancer treatment str ..."
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Angiogenesis is a multistep process regulated by pro- and antiangiogenic factors. In order to grow and me-tastasize, tumors need a constant supply of oxygen and nutrients. For growth beyond 1–2 mm in size, tumors are dependent on angiogenesis. Inhibition of angiogenesis is a new cancer treatment
Extracellular Matrix Proteins and Tumor Angiogenesis
"... Tumor development is a complex process that relies on interaction and communication between a number of cellular compartments. Much of the mass of a solid tumor is comprised of the stroma which is richly invested with extracellular matrix. Within this matrix are a host of matricellular proteins tha ..."
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that regulate the expression and function of a myriad of proteins that regulate tumorigenic processes. One of the processes that is vital to tumor growth and progression is angiogenesis, or the formation of new blood vessels from preexisting vasculature. Within the extracellular matrix are structural proteins
Editorial Tumor Angiogenesis
"... License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In a seminal New England Journal of Medicine article, published 40 years ago, Folkman proposed the concept that angiogenesis could be a target for cancer therapy [1]. ..."
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to cautiously conclude that “...the mechanism by which tumor implants stimulate neovascularization must be well understood before therapy based upon interference with angiogenesis can be devised. ” Since then, a wide variety of antiangiogenic therapies have been tested in clinical trails,
for Targeting Tumor Angiogenesis
, 2015
"... elot, et al.. ”Click ” Conjugation of Peptide on the Surface of Polymeric Nanoparticles for ..."
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elot, et al.. ”Click ” Conjugation of Peptide on the Surface of Polymeric Nanoparticles for
RESEARCH ARTICLE Tumor Angiogenesis in the Absence of
"... Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin sub-strate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth. However, clinical trials of blocking antibodies and peptides have been disappointing de ..."
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Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin sub-strate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth. However, clinical trials of blocking antibodies and peptides have been disappointing
INHIBITION OF TUMOR ANGIOGENESIS MEDIATED BY CARTILAGE*
"... We have previously suggested that solid tumor growth is not continuous, but may be separated into two stages, avascular and vascular (1, 2). In the avascular phase, spheroidal tumors cannot generally exceed a diameter of 1-2 mm or a population of more than 10 8 cells (3, 4). Further growth occurs af ..."
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after new capillaries have been elicited from the host, and have penetrated the tumor. Tumors elicit these new capillaries from the host by re-leasing a diffusible material, which we have termed tumor-angiogenesis-factor (TAF), which is mitogenic to capillary endothelial cells (5-S). Under the usual
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