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The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

by Amos Bairoch, Rolf Apweiler - Nucleic Acids Res , 2000
"... SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with othe ..."
Abstract - Cited by 773 (21 self) - Add to MetaCart
the translation of all coding sequences (CDSs) in the EMBL Nucleotide Sequence Database, except the CDSs already included in SWISS-PROT. We also describe the Human Proteomics Initiative (HPI), a major project to annotate all known human sequences according to the quality standards of SWISS-PROT. SWISS

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

by Amos Bairoch, Rolf Apweiler - Nucleic Acids Res , 1999
"... SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domain structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other ..."
Abstract - Cited by 624 (5 self) - Add to MetaCart
SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domain structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration

The complete genome sequence of Escherichia coli K-12

by Frederick R. Blattner, Guy Plunkett Iii, Craig A. Bloch, Nicole T. Perna, Valerie Burl, Monica Riley, Julio Collado-vides, Jeremy D. Glasner, Christopher K. Rode, George F. Mayhew, Jason Gregor, Nelson Wayne Davis, Heather A. Kirkpatrick, Michael A. Goeden, Debra J. Rose, Bob Mau, Ying Shao - Science , 1997
"... The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes withi ..."
Abstract - Cited by 1129 (39 self) - Add to MetaCart
The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes

Supplemental Information

by unknown authors
"... Composition-based statitistics and translated nucleotide sequences 1 ..."
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Composition-based statitistics and translated nucleotide sequences 1

Tandem repeats finder: a program to analyze DNA sequences

by Gary Benson , 1999
"... A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size, co ..."
Abstract - Cited by 961 (9 self) - Add to MetaCart
A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size

Maximum Likelihood Phylogenetic Estimation from DNA Sequences with Variable Rates over Sites: Approximate Methods

by Ziheng Yang - J. Mol. Evol , 1994
"... Two approximate methods are proposed for maximum likelihood phylogenetic estimation, which allow variable rates of substitution across nucleotide sites. Three data sets with quite different characteristics were analyzed to examine empirically the performance of these methods. The first, called ..."
Abstract - Cited by 557 (29 self) - Add to MetaCart
Two approximate methods are proposed for maximum likelihood phylogenetic estimation, which allow variable rates of substitution across nucleotide sites. Three data sets with quite different characteristics were analyzed to examine empirically the performance of these methods. The first, called

What is a hidden Markov model?

by Sean R. Eddy , 2004
"... Often, problems in biological sequence analysis are just a matter of putting the right label on each residue. In gene identification, we want to label nucleotides as exons, introns, or intergenic sequence. In sequence alignment, we want to associate residues in a query sequence with ho-mologous resi ..."
Abstract - Cited by 1344 (8 self) - Add to MetaCart
Often, problems in biological sequence analysis are just a matter of putting the right label on each residue. In gene identification, we want to label nucleotides as exons, introns, or intergenic sequence. In sequence alignment, we want to associate residues in a query sequence with ho

Mega: molecular evolutionary genetic analysis software for microcomputers

by Sudhir Kumar, Koichiro Tamura, Masatoshi Nei - CABIOS , 1994
"... A computer program package called MEGA has been developed for estimating evolutionary distances, reconstructing phylogenetic trees and computing basic statistical quantities from molecular data. It is written in C+ + and is intended to be used on IBM and IBM-compatible personal computers. In this pr ..."
Abstract - Cited by 505 (10 self) - Add to MetaCart
. In this program, various methods for estimating evolutionary distances from nucleotide and amino acid sequence data, three different methods of phylogenetic inference (UPGMA, neighbor-joining and maximum parsimony) and two statistical tests of topological differences are included. For the maximum parsimony method

PAML: a program package for phylogenetic analysis by maximum likelihood

by Ziheng Yang - COMPUT APPL BIOSCI 13:555–556 , 1997
"... PAML, currently in version 1.2, is a package of programs for phylogenetic analyses of DNA and protein sequences using the method of maximum likelihood (ML). The programs can be used for (i) maximum likelihood estimation of evolutionary parameters such as branch lengths in a phylogenetic tree, the tr ..."
Abstract - Cited by 1459 (17 self) - Add to MetaCart
among lineages (the molecular clock); (iii) calculation of sub-stitution rates at sites and reconstruction of ancestral nucleo-tide or amino acid sequences; and (iv) phylogenetic tree reconstruction by maximum likelihood and Bayesian methods.

MEGA5: Molecular evolutionary genetics analysis using maximum . . .

by Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar , 2011
"... Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. Here, we announce the release of Molecular Evolutionary Genetics Analysis version ..."
Abstract - Cited by 7284 (25 self) - Add to MetaCart
) analyses for inferring evolutionary trees, selecting best-fit substitution models (nucleotide or amino acid), inferring ancestral states and sequences (along with probabilities), and estimating evolutionary rates site-by-site. In computer simulation analyses, ML tree inference algorithms in MEGA5 compared
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