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Safety Analysis of Sugar Cataract Development Using Stochastic Hybrid Systems
- HYBRID SYSTEMS: COMPUTATION AND CONTROL 2007 LNCS 4416
, 2007
"... Modeling and analysis of biochemical systems are critical problems because they can provide new insights into systems which can not be easily tested with real experiments. One such biochemical process is the formation of sugar cataracts in the lens of an eye. Analyzing the sugar cataract developmen ..."
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Cited by 6 (5 self)
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Modeling and analysis of biochemical systems are critical problems because they can provide new insights into systems which can not be easily tested with real experiments. One such biochemical process is the formation of sugar cataracts in the lens of an eye. Analyzing the sugar cataract
Changes associated with the appearance of mature sugar cataracts
"... I n diabetic and galactose-fed rats the appearance of a mature lens cataract, as a white opacity which is visible to the naked eye, is sudden and accompanied by striking physiologic and biochemical changes. 1 It is the purpose of this paper to present, in a graphic manner, the course of these chang ..."
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of onset of a mature cataract is readily determined. Diabetes was produced in 27 to 38-day-old male Sprague-Dawley rats by the intravenous injection of 50 mg. of alloxan monohydrate per kilogram of body weight. Only rats with average blood sugars above 400 mg. per cent were used. The average blood sugar
Modeling and simulation of biochemical processes using stochastic hybrid systems: The sugar cataract development process
- IN HYBRID SYSTEMS COMPUTATION AND CONTROL LNCS 4981
, 2008
"... As biomedical research advances there is an increasing need to model and simulate more complicated systems to better understand them. Since biochemical processes are inherently stochastic and often contain both continuous and discrete behavior, stochastic hybrid systems are an ideal modeling paradi ..."
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Cited by 4 (3 self)
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paradigm for capturing their dynamics. In this paper we present a framework for modeling biochemical systems and demonstrate the approach for the sugar cataract development process including two methods of modeling drug treatment. Further, we present a simulation method that uses second-order Taylor
NONENZYMATIC GLYCOSYLATION, SULFHYDRYL OXIDATION, AND AGGREGATION OF LENS PROTEINS IN EXPERIMENTAL SUGAR CATARACTS*
"... In studies of human cataracts, Dische and Zil (I) first noted that the proteins of the human cataractous lens were associated with a marked increase in sulflaydryl oxidation to form disulfide bonds. The correlation of disulfide bonds and cataract formation has been combined subsequently by a number ..."
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Cited by 3 (0 self)
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In studies of human cataracts, Dische and Zil (I) first noted that the proteins of the human cataractous lens were associated with a marked increase in sulflaydryl oxidation to form disulfide bonds. The correlation of disulfide bonds and cataract formation has been combined subsequently by a number
Modelling and analysis of the sugar cataract development process using stochastic hybrid systems
- IET SYSTEMS BIOLOGY
, 2008
"... ..."
CATARACTS IN GALACTOSAEMIA* BY
"... WHEN milk is taken by mouth, the lactose that it contains (breast milk contains a higher concentration than cow's milk) is hydrolysed by the enzyme lactase into its constituent monosaccharides, glucose and galactose, which are absorbed from the intestine, p'robably by a process of phosphor ..."
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is interrupted, and in consequence the blood level of the sugar rises, allowing a considerable quantity to appear in the urine. The basic cause of the disease is said to be a defective enzyme system in the liver, the exact nature of which is, as yet, unknown. Clinical features of the disease are a failure
Research Article Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats
"... Copyright © 2013 Junghyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cataracts are a major cause of human blindness. ..."
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. Aldose reductase (AR) is an important rate-limiting enzyme that contributes to cataract induction in diabetic patients. Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii and is known to inhibit AR activity. To assess scopoletin’s ability to mitigate sugar cataract
Effect of Aldose Reductase Inhibitors on Naphthalene Cataract Formation in the Rat
"... Naphthalene feeding can result in cataract formation in rats and rabbits due to specific metabolites of naphthalene. The concomitant administration of the aldose reductase inhibitor All 576 to naphthalenefed rats was proven to prevent cataract formation. To determine whether this effect was directl ..."
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naphthalene-induced cataracts. Brown Norway rats, administered naphthalene by gavagc, were fed normal rat chow containing these aldose reductase inhibitors at levels known to inhibit sugar cataract formation. The lens changes in these rats were monitored over a 90-day period by portable slit-lamp microscopy
Autotrichograft sutures in cataract
"... Suturing in cataract surgery is now practised almost universally. Advances in materials and techniques are enabling us to achieve more satisfactory wound healing with a shorter duration of postoperative inflammation. The suture material needs to be of fine calibre, non-irritant, absorbable, non-anti ..."
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suture sites was studied by Sugar and Deen (i963), who stressed the importance of coaptation of the wound edges as determined by the even penetration of the needle at the two edges. Epithelial downgrowth, a very discouraging complication of cataract surgery, has been
Orally Active Multi-Functional Antioxidants Delay Cataract Formation in Streptozotocin (Type 1) Diabetic and Gamma-Irradiated Rats
"... Background: Age-related cataract is a worldwide health care problem whose progression has been linked to oxidative stress and the accumulation of redox-active metals. Since there is no specific animal model for human age-related cataract, multiple animal models must be used to evaluate potential the ..."
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Cited by 1 (0 self)
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-sulfonamide (compound 8), multi-functional antioxidants that can independently chelate redox metals and quench free radicals, on their ability to delay the progression of diabetic ‘‘sugar’ ’ cataracts and gamma radiationinduced cataracts. Prior to 15 Gy of whole head irradiation, select groups of Long Evans
Results 1 - 10
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29
