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Safety Analysis of Sugar Cataract Development Using Stochastic Hybrid Systems
- HYBRID SYSTEMS: COMPUTATION AND CONTROL 2007 LNCS 4416
, 2007
"... Modeling and analysis of biochemical systems are critical problems because they can provide new insights into systems which can not be easily tested with real experiments. One such biochemical process is the formation of sugar cataracts in the lens of an eye. Analyzing the sugar cataract developmen ..."
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Cited by 6 (5 self)
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Modeling and analysis of biochemical systems are critical problems because they can provide new insights into systems which can not be easily tested with real experiments. One such biochemical process is the formation of sugar cataracts in the lens of an eye. Analyzing the sugar cataract
Effect of Aldose Reductase Inhibitors on Naphthalene Cataract Formation in the Rat
"... Naphthalene feeding can result in cataract formation in rats and rabbits due to specific metabolites of naphthalene. The concomitant administration of the aldose reductase inhibitor All 576 to naphthalenefed rats was proven to prevent cataract formation. To determine whether this effect was directl ..."
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naphthalene-induced cataracts. Brown Norway rats, administered naphthalene by gavagc, were fed normal rat chow containing these aldose reductase inhibitors at levels known to inhibit sugar cataract formation. The lens changes in these rats were monitored over a 90-day period by portable slit-lamp microscopy
Changes associated with the appearance of mature sugar cataracts
"... I n diabetic and galactose-fed rats the appearance of a mature lens cataract, as a white opacity which is visible to the naked eye, is sudden and accompanied by striking physiologic and biochemical changes. 1 It is the purpose of this paper to present, in a graphic manner, the course of these chang ..."
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for mature cataract formation was 18 days. The lenses were removed as previously described. 2 Individual lenses were macerated in 1 ml. of 2.0 per cent zinc sulfate and 1 ml. of 1.8 per cent barium hydroxide. The proteins were removed by centrifuging and 0.5 aliquots were used for determining reduced sugars
NONENZYMATIC GLYCOSYLATION, SULFHYDRYL OXIDATION, AND AGGREGATION OF LENS PROTEINS IN EXPERIMENTAL SUGAR CATARACTS*
"... In studies of human cataracts, Dische and Zil (I) first noted that the proteins of the human cataractous lens were associated with a marked increase in sulflaydryl oxidation to form disulfide bonds. The correlation of disulfide bonds and cataract formation has been combined subsequently by a number ..."
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Cited by 3 (0 self)
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In studies of human cataracts, Dische and Zil (I) first noted that the proteins of the human cataractous lens were associated with a marked increase in sulflaydryl oxidation to form disulfide bonds. The correlation of disulfide bonds and cataract formation has been combined subsequently by a number
Research Article Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats
"... Copyright © 2013 Junghyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cataracts are a major cause of human blindness. ..."
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formation in vivo, we studied its effects in a rat model of dietary galactose-induced sugar cataracts. Galactose-fed rats were orally dosed with scopoletin (10 or 50mg/kg body weight) once a day for 2 weeks. Administering scopoletin delayed the progression of the cataracts that were induced by dietary
Behavioral theories and the neurophysiology of reward,
- Annu. Rev. Psychol.
, 2006
"... ■ Abstract The functions of rewards are based primarily on their effects on behavior and are less directly governed by the physics and chemistry of input events as in sensory systems. Therefore, the investigation of neural mechanisms underlying reward functions requires behavioral theories that can ..."
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Cited by 187 (0 self)
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, without attempting to provide a complete account of all the studies done. We focus on the activity of single neurons studied by neurophysiological techniques in behaving animals, in particular monkeys, and emphasize the formative role of behavioral theories, such as animal learning theory
cataract formation in the mouse lens
"... kynurenine-modification of proteins, fiber cell apoptosis and ..."
CATARACTS IN GALACTOSAEMIA* BY
"... WHEN milk is taken by mouth, the lactose that it contains (breast milk contains a higher concentration than cow's milk) is hydrolysed by the enzyme lactase into its constituent monosaccharides, glucose and galactose, which are absorbed from the intestine, p'robably by a process of phosphor ..."
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is interrupted, and in consequence the blood level of the sugar rises, allowing a considerable quantity to appear in the urine. The basic cause of the disease is said to be a defective enzyme system in the liver, the exact nature of which is, as yet, unknown. Clinical features of the disease are a failure
Allopurinol use and the risk of cataract formation
"... SUMMARY Several reports have suggested an association between chronic allopurinol ingestion and cortical and subcapsular cataract formation. To examine this possibility we identified 51 allopurinol users and compared their lenses with those of 76 patients who did not use allopurinol. The existence o ..."
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SUMMARY Several reports have suggested an association between chronic allopurinol ingestion and cortical and subcapsular cataract formation. To examine this possibility we identified 51 allopurinol users and compared their lenses with those of 76 patients who did not use allopurinol. The existence
The Effect of Trabeculectomy on Cataract Formation or Progression
, 2008
"... Purpose: To determine the effect of trabeculectomy on cataract formation or progression in patients with chronic glaucoma. Methods: This controlled clinical trial was performed on patients over 50 years of age with glaucoma who were referred to Imam Hossein Hospital, Tehran, Iran, from 2006 to 2007. ..."
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Purpose: To determine the effect of trabeculectomy on cataract formation or progression in patients with chronic glaucoma. Methods: This controlled clinical trial was performed on patients over 50 years of age with glaucoma who were referred to Imam Hossein Hospital, Tehran, Iran, from 2006 to 2007
Results 1 - 10
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1,095