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Safety Analysis of Sugar Cataract Development Using Stochastic Hybrid Systems
- HYBRID SYSTEMS: COMPUTATION AND CONTROL 2007 LNCS 4416
, 2007
"... Modeling and analysis of biochemical systems are critical problems because they can provide new insights into systems which can not be easily tested with real experiments. One such biochemical process is the formation of sugar cataracts in the lens of an eye. Analyzing the sugar cataract developmen ..."
Abstract
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Cited by 6 (5 self)
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development process is a challenging problem due to the highly-coupled chemical reactions that are involved. In this paper we model sugar cataract development as a stochastic hybrid system. Based on this model, we present a probabilistic verification method for computing the probability of sugar cataract
Modeling and simulation of biochemical processes using stochastic hybrid systems: The sugar cataract development process
- IN HYBRID SYSTEMS COMPUTATION AND CONTROL LNCS 4981
, 2008
"... As biomedical research advances there is an increasing need to model and simulate more complicated systems to better understand them. Since biochemical processes are inherently stochastic and often contain both continuous and discrete behavior, stochastic hybrid systems are an ideal modeling paradi ..."
Abstract
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Cited by 4 (3 self)
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paradigm for capturing their dynamics. In this paper we present a framework for modeling biochemical systems and demonstrate the approach for the sugar cataract development process including two methods of modeling drug treatment. Further, we present a simulation method that uses second-order Taylor
Modelling and analysis of the sugar cataract development process using stochastic hybrid systems
- IET SYSTEMS BIOLOGY
, 2008
"... ..."
A photometric adaptation of the Somogyi method for the determination of glucose
- J. Biol. Chem. 1944
"... The reliability of the various Somogyi-Shaffer-Hartmann (1, 2) copper reagents for glucose determination in biological material has been estab-lished. Adaptation of these reagents to calorimetric use may be accom-plished by omission of the iodide and iodate in their preparation, since these interfer ..."
Abstract
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Cited by 410 (0 self)
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much to be desired in reproducibility from time to time and lacked the desired stability of color. We therefore tried various color reagents, which led to the development of a new arsenomolybdate reagent. When this reagent was used with Somogyi’s micro reagent, it gave satisfactory stability
Sugar-induced signal transduction in plants
- Plant Molecular Biology
"... Key Words hexose sensing, sucrose sensing, hexokinase, phytohormones, Arabidopsis, signal transduction n Abstract Sugars have important signaling functions throughout all stages of the plant’s life cycle. This review presents our current understanding of the different mechanisms of sugar sensing and ..."
Abstract
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Cited by 121 (1 self)
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transduction cascade by analyzing the function of the SNF1 kinase complex and the regulatory PRL1 protein. The role of sugar signaling in seed development and in seed germination is discussed, especially with respect to the various mechanisms by which sugar signaling controls gene expression. Finally, recent
Behavioral theories and the neurophysiology of reward,
- Annu. Rev. Psychol.
, 2006
"... ■ Abstract The functions of rewards are based primarily on their effects on behavior and are less directly governed by the physics and chemistry of input events as in sensory systems. Therefore, the investigation of neural mechanisms underlying reward functions requires behavioral theories that can ..."
Abstract
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Cited by 187 (0 self)
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is the precise definition of the rewarding effect. Is it the seeing of an apple, its taste on the tongue, the swallowing of a bite of it, the feeling of its going down the throat, or the rise in blood sugar subsequent to its digestion that makes it a reward and has one come back for more? Which of these events
Sugar and hormone connections
- Trends in Plant Science
, 2003
"... Sugars modulate many vital processes that are also controlled by hormones during plant growth and devel-opment. Characterization of sugar-signalling mutants in Arabidopsis has unravelled a complex signalling net-work that links sugar responses to two plant stress hormones – abscisic acid and ethylen ..."
Abstract
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Cited by 76 (1 self)
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Sugars modulate many vital processes that are also controlled by hormones during plant growth and devel-opment. Characterization of sugar-signalling mutants in Arabidopsis has unravelled a complex signalling net-work that links sugar responses to two plant stress hormones – abscisic acid
Changes associated with the appearance of mature sugar cataracts
"... I n diabetic and galactose-fed rats the appearance of a mature lens cataract, as a white opacity which is visible to the naked eye, is sudden and accompanied by striking physiologic and biochemical changes. 1 It is the purpose of this paper to present, in a graphic manner, the course of these chang ..."
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of onset of a mature cataract is readily determined. Diabetes was produced in 27 to 38-day-old male Sprague-Dawley rats by the intravenous injection of 50 mg. of alloxan monohydrate per kilogram of body weight. Only rats with average blood sugars above 400 mg. per cent were used. The average blood sugar
2004 ). Congenital hereditary cataracts
- Int J Dev Biol 48 : 1031 – 1044
"... ABSTRACT Congenital cataracts are rare and occur in developed countries with a frequency of 30 cases among 100,000 births with a further 10 cases being diagnosed during childhood. They reflect mainly genetically caused developmental alterations in the lens and surrounding ocular tissues. Even if mod ..."
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Cited by 37 (4 self)
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ABSTRACT Congenital cataracts are rare and occur in developed countries with a frequency of 30 cases among 100,000 births with a further 10 cases being diagnosed during childhood. They reflect mainly genetically caused developmental alterations in the lens and surrounding ocular tissues. Even
CATARACTS IN GALACTOSAEMIA* BY
"... WHEN milk is taken by mouth, the lactose that it contains (breast milk contains a higher concentration than cow's milk) is hydrolysed by the enzyme lactase into its constituent monosaccharides, glucose and galactose, which are absorbed from the intestine, p'robably by a process of phosphor ..."
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is interrupted, and in consequence the blood level of the sugar rises, allowing a considerable quantity to appear in the urine. The basic cause of the disease is said to be a defective enzyme system in the liver, the exact nature of which is, as yet, unknown. Clinical features of the disease are a failure
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