classification of protein domain structures (CATH). The four main levels of our classification are protein class (C), architecture (A), topology (T) and homologous superfamily (H). Class is the simplest level, and it essentially describes the secondary structure composition of each domain. In contrast

We develop a connectionist approach to processing in quasi-regular domains, as exemplified by English word reading. A consideration of the shortcomings of a previous implementation (Seidenberg & McClelland, 1989, Psych. Rev.) in reading nonwords leads to the development of orthographic

In this paper we explore a new theory of discourse structure that stresses the role of purpose and processing in discourse. In this theory, discourse structure is composed of three separate but interre-lated components: the structure of the sequence of utterances (called the linguistic structure

the complementary issue of designing classification algorithms that can deal with more complex outputs, such as trees, sequences, or sets. More generally, we consider problems involving multiple dependent output variables, structured output spaces, and classification problems with class attributes. In order

to represent the generic knowledge of a domain expert, and it turns into a computational architecture if the links are used not merely for storing factual knowledge but also for directing and activating the data flow in the computations which manipulate this knowledge. The first part of the paper deals

for learning M 3 networks based on a compact quadratic program formulation. We provide a new theoretical bound for generalization in structured domains. Experiments on the task of handwritten character recognition and collective hypertext classification demonstrate very significant gains over previous

include modelling of discontinuous domains allow-ing Pfam domain de®nitions to be closer to those found in structure databases. Pfam is available on the web in the UK

Anomaly detection is an important problem that has been researched within diverse research areas and application domains. Many anomaly detection techniques have been specifically developed for certain application domains, while others are more generic. This survey tries to provide a structured

We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIM’s). Learning is treated as a max-imum likelihood

It is a striking fact that in humans the greatest learnmg occurs precisely at that point in time- childhood- when the most dramatic maturational changes also occur. This report describes possible synergistic interactions between maturational change and the ability to learn a complex domain