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Production and Characterization of Murine Monoclonal Antibodies to Leishmania Gp63 Antigen
"... Background: Production of monoclonal antibodies to Leishmania antigens assists the identification and characterization of these organisms. Objective: Production of monoclonal antibodies against epitopes on the gp63. Methods: Two murine monoclonal antibodies to gp63 were produced and characterized. T ..."
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. The reactions of both antibodies with soluble leishmanial antigens, purified gp63 and truncated recombinant gp63 molecules were studied by an ELISA assay. These two antibodies reacted with the crude soluble antigens prepared from 4 reference strains of Leishmania, 10 isolates from the patients, purified gp63
Trypanosoma cruzi GP63 Proteins Undergo Stage-Specific Differential Posttranslational Modification and Are Important for
, 2009
"... The protozoan Trypanosoma cruzi expresses multiple isoforms of the GP63 family of metalloproteases. Polyclonal antiserum against recombinant GP63 of T. cruzi (TcGP63) was used to study TcGP63 expression and localization in this organism. Western blot analysis revealed that TcGP63 is 61 kDa in epimas ..."
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intracellularly in metacyclic trypo-mastigotes. TcGP63 is soluble in cold Triton X-100, in contrast to Leishmania GP63, which is detergent resistant in this medium, suggesting that GP63 is not raft associated in T. cruzi. Western blot comparison of our antiserum to a previously described anti-peptide TcGP63
Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite
"... Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro-inflammatory cytokin ..."
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, soluble GP63 could use a phagocytosis-independent mechanism to enter the host cell. In support of this, disruption of macrophage lipid raft microdomains by Methyl b-Cyclodextrin (MbCD) partially inhibits the degradation of full length c-Jun. Together our
Leishmania mexicana Gp63 cDNA Using Gene Gun Induced Higher Immunity to L. mexicana Infection Compared to Soluble Leishmania Antigen in BALB/C
, 2011
"... ..."
unknown title
, 2005
"... (See the article by the rgp120 HIV Vaccine Study Group, on pages 654–65, and the editorial commentary by Graham and Mascola, on pages 647–9.) Background. An objective of the firs efficac trial of a candidate vaccine containing recombinant human immunodeficienc virus (HIV) type 1 envelope glycoprotei ..."
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titer against HIV-1MN, and the RRs of infection for second-, third-, and fourth-quartile responses of antibody blocking of gp120 binding to soluble CD4 versus first-qua tile responses (the lowest responses) were 0.35, 0.28, and 0.22, respectively. Conclusions. Despite inducing a complex, robust immune
MAJOR ARTICLE Correlation between Immunologic Responses to a Recombinant Glycoprotein 120 Vaccine and Incidence of HIV-1 Infection in a Phase 3
"... (See the article by the rgp120 HIV Vaccine Study Group, on pages 654–65, and the editorial commentary by Graham and Mascola, on pages 647–9.) Background. An objective of the first efficacy trial of a candidate vaccine containing recombinant human immunodeficiency virus (HIV) type 1 envelope glycopro ..."
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titer against HIV-1MN, and the RRs of infection for second-, third-, and fourth-quartile responses of antibody blocking of gp120 binding to soluble CD4 versus first-quartile responses (the lowest responses) were 0.35, 0.28, and 0.22, respectively. Conclusions. Despite inducing a complex, robust immune
Physical Aspects of Viral Membrane Fusion
- Sci. J. 2009
"... Enveloped viruses commonly employ membrane fusion during cell penetration in order to deliver their genetic material across the cell boundary. Large conformational changes in the proteins embedded in the viral membrane play a fundamental role in the membrane fusion process. Despite the tremendously ..."
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of the experimental and computational techniques presently being used to investigate viral-mediated membrane fusion. KEYWORDS: viral membrane fusion; class I, II, and III fusion proteins; hemagluttin (HA); E1; gp64 INTRODUCTION Membrane fusion is a vital phenomenon that allows eukaryotic cells to transfer materials
Determining hydrodynamic forces in bursting bubbles using DNA nanotube mechanics
"... Quantifying the mechanical forces produced by fluid flows within the ocean is critical to understanding the ocean's environmental phenomena. Such forces may have been instrumental in the origin of life by driving a primitive form of self-replication through fragmentation. Among the intense sou ..."
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already been extensively characterized (34). Second, they are highly soluble in water and do not exhibit a surfactant-like tendency to stick to the air-water interface, unlike many proteins. Third, it is straightforward to measure histograms of nanotube lengths using fluorescence microscopy. Here, from
Results 1 - 10
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