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34,204
Bayesian Interpolation
 Neural Computation
, 1991
"... Although Bayesian analysis has been in use since Laplace, the Bayesian method of modelcomparison has only recently been developed in depth. In this paper, the Bayesian approach to regularisation and modelcomparison is demonstrated by studying the inference problem of interpolating noisy data. T ..."
Abstract

Cited by 721 (17 self)
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. The concepts and methods described are quite general and can be applied to many other problems. Regularising constants are set by examining their posterior probability distribution. Alternative regularisers (priors) and alternative basis sets are objectively compared by evaluating the evidence for them
On Sequential Monte Carlo Sampling Methods for Bayesian Filtering
 STATISTICS AND COMPUTING
, 2000
"... In this article, we present an overview of methods for sequential simulation from posterior distributions. These methods are of particular interest in Bayesian filtering for discrete time dynamic models that are typically nonlinear and nonGaussian. A general importance sampling framework is develop ..."
Abstract

Cited by 1032 (76 self)
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In this article, we present an overview of methods for sequential simulation from posterior distributions. These methods are of particular interest in Bayesian filtering for discrete time dynamic models that are typically nonlinear and nonGaussian. A general importance sampling framework
Sparse Bayesian Learning and the Relevance Vector Machine
, 2001
"... This paper introduces a general Bayesian framework for obtaining sparse solutions to regression and classication tasks utilising models linear in the parameters. Although this framework is fully general, we illustrate our approach with a particular specialisation that we denote the `relevance vec ..."
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Cited by 958 (5 self)
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This paper introduces a general Bayesian framework for obtaining sparse solutions to regression and classication tasks utilising models linear in the parameters. Although this framework is fully general, we illustrate our approach with a particular specialisation that we denote the `relevance vector machine' (RVM), a model of identical functional form to the popular and stateoftheart `support vector machine' (SVM). We demonstrate that by exploiting a probabilistic Bayesian learning framework, we can derive accurate prediction models which typically utilise dramatically fewer basis functions than a comparable SVM while oering a number of additional advantages. These include the benets of probabilistic predictions, automatic estimation of `nuisance' parameters, and the facility to utilise arbitrary basis functions (e.g. non`Mercer' kernels).
Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation
, 2002
"... There are many sources of systematic variation in cDNA microarray experiments which affect the measured gene expression levels (e.g. differences in labeling efficiency between the two fluorescent dyes). The term normalization refers to the process of removing such variation. A constant adjustment is ..."
Abstract

Cited by 699 (9 self)
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There are many sources of systematic variation in cDNA microarray experiments which affect the measured gene expression levels (e.g. differences in labeling efficiency between the two fluorescent dyes). The term normalization refers to the process of removing such variation. A constant adjustment is often used to force the distribution of the intensity log ratios to have a median of zero for each slide. However, such global normalization approaches are not adequate in situations where dye biases can depend on spot overall intensity and/or spatial location within the array. This article proposes normalization methods that are based on robust local regression and account for intensity and spatial dependence in dye biases for different types of cDNA microarray experiments. The selection of appropriate controls for normalization is discussed and a novel set of controls (microarray sample pool, MSP) is introduced to aid in intensitydependent normalization. Lastly, to allow for comparisons of expression levels across slides, a robust method based on maximum likelihood estimation is proposed to adjust for scale differences among slides.
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
, 2003
"... The increase in the number of large data sets and the complexity of current probabilistic sequence evolution models necessitates fast and reliable phylogeny reconstruction methods. We describe a new approach, based on the maximumlikelihood principle, which clearly satisfies these requirements. The ..."
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Cited by 2109 (30 self)
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The increase in the number of large data sets and the complexity of current probabilistic sequence evolution models necessitates fast and reliable phylogeny reconstruction methods. We describe a new approach, based on the maximumlikelihood principle, which clearly satisfies these requirements. The core of this method is a simple hillclimbing algorithm that adjusts tree topology and branch lengths simultaneously. This algorithm starts from an initial tree built by a fast distancebased method and modifies this tree to improve its likelihood at each iteration. Due to this simultaneous adjustment of the topology and branch lengths, only a few iterations are sufficient to reach an optimum. We used extensive and realistic computer simulations to show that the topological accuracy of this new method is at least as high as that of the existing maximumlikelihood programs and much higher than the performance of distancebased and parsimony approaches. The reduction of computing time is dramatic in comparison with other maximumlikelihood packages, while the likelihood maximization ability tends to be higher. For example, only 12 min were required on a standard personal computer to analyze a data set consisting of 500 rbcL sequences with 1,428 base pairs from plant plastids, thus reaching a speed of the same order as some popular distancebased and parsimony algorithms. This new method is implemented in the PHYML program, which is freely available on our web page:
Image denoising using a scale mixture of Gaussians in the wavelet domain
 IEEE TRANS IMAGE PROCESSING
, 2003
"... We describe a method for removing noise from digital images, based on a statistical model of the coefficients of an overcomplete multiscale oriented basis. Neighborhoods of coefficients at adjacent positions and scales are modeled as the product of two independent random variables: a Gaussian vecto ..."
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Cited by 514 (17 self)
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We describe a method for removing noise from digital images, based on a statistical model of the coefficients of an overcomplete multiscale oriented basis. Neighborhoods of coefficients at adjacent positions and scales are modeled as the product of two independent random variables: a Gaussian vector and a hidden positive scalar multiplier. The latter modulates the local variance of the coefficients in the neighborhood, and is thus able to account for the empirically observed correlation between the coefficient amplitudes. Under this model, the Bayesian least squares estimate of each coefficient reduces to a weighted average of the local linear estimates over all possible values of the hidden multiplier variable. We demonstrate through simulations with images contaminated by additive white Gaussian noise that the performance of this method substantially surpasses that of previously published methods, both visually and in terms of mean squared error.
Training Support Vector Machines: an Application to Face Detection
, 1997
"... We investigate the application of Support Vector Machines (SVMs) in computer vision. SVM is a learning technique developed by V. Vapnik and his team (AT&T Bell Labs.) that can be seen as a new method for training polynomial, neural network, or Radial Basis Functions classifiers. The decision sur ..."
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Cited by 728 (1 self)
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We investigate the application of Support Vector Machines (SVMs) in computer vision. SVM is a learning technique developed by V. Vapnik and his team (AT&T Bell Labs.) that can be seen as a new method for training polynomial, neural network, or Radial Basis Functions classifiers. The decision surfaces are found by solving a linearly constrained quadratic programming problem. This optimization problem is challenging because the quadratic form is completely dense and the memory requirements grow with the square of the number of data points. We present a decomposition algorithm that guarantees global optimality, and can be used to train SVM's over very large data sets. The main idea behind the decomposition is the iterative solution of subproblems and the evaluation of optimality conditions which are used both to generate improved iterative values, and also establish the stopping criteria for the algorithm. We present experimental results of our implementation of SVM, and demonstrate the ...
Minimum Error Rate Training in Statistical Machine Translation
, 2003
"... Often, the training procedure for statistical machine translation models is based on maximum likelihood or related criteria. A general problem of this approach is that there is only a loose relation to the final translation quality on unseen text. In this paper, we analyze various training cri ..."
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Cited by 663 (7 self)
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Often, the training procedure for statistical machine translation models is based on maximum likelihood or related criteria. A general problem of this approach is that there is only a loose relation to the final translation quality on unseen text. In this paper, we analyze various training criteria which directly optimize translation quality.
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