, the transition/transversion rate ratio, the shape parameter of the gamma distribution for variable evolutionary rates at sites, and rate parameters for different genes; (ii) likelihood ratio test of hypotheses concerning sequence evolution, such as rate con-stancy and independence among sites and rate constancy

We have systematically made a set of precisely defined, single-gene deletions of all nonessential genes in Escherichia coli K-12. Open-reading frame coding regions were replaced with a kanamycin cassette flanked by FLP recognition target sites by using a one-step method for inactivation

, the effect of user "think time", and the superimposition of many such transfers in a local area network. To do this we rely on empirically measured distributions both from our traces and from data independently collected at over thirty WWW sites.

Abstract We discuss findings from a large-scale study of Internet packet dynamics conducted by tracing 20,000 TCP bulk transfers between 35 Internet sites. Because we traced each 100 Kbyte transfer at both the sender and the receiver, the measurements allow us to distinguish between the end

Designing and maintaining Web applications is one of the major challenges for the software industry of the year 2000. In this paper we present Web Modeling Language (WebML), a notation for specifying complex Web sites at the conceptual level. WebML enables the high-level description of a Web site

by using within-site template discovery techniques to drive the induction of a site-independent template detector. Our approach eliminates the need for human annotation and produces highly effective models. Experimental results demonstrate the usefulness

Abstract—The authors evaluated a site-independent telemedicine system. Telemedicine may be limited by the need for fixed connectivity. Wireless and site-independent technologies eliminate this limitation. Twenty-five stroke pa-tients underwent evaluations by remote and bedside examiners. Ten of 15

automatically extract information from unfamiliar Web sites? (4) What aspects of the Web facilitate this competence? In this paper we investigate these issues with a case study using the ShopBot. ShopBot is a fullyimplemented, domain-independent comparison-shopping agent. Given the home pages of several on

user’s long-term interests, our system learns user-independent patterns of behavior that identify the user’s current information need, based on his/her current browsing session, then uses this information to suggest specific pages intended to address this need. Our system learns these behavior patterns

to explore the solution space and makes the split and merge process reversible at a middle level vision formulation. Thus it achieves globally optimal solution independent of initial segmentations. Secondly, instead of computing a single maximum a posteriori solution, it proposes a mathematical principle