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Results 11 - 20
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256
JB Review Molecular properties of the high-affinity choline transporter
, 2014
"... This article summarizes molecular properties of the high-affinity choline transporter (CHT1) with reference to the historical background focusing studies performed in laboratories of the author. CHT1 is present on the pre-synaptic terminal of cholinergic neurons, and takes up choline which is the pr ..."
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This article summarizes molecular properties of the high-affinity choline transporter (CHT1) with reference to the historical background focusing studies performed in laboratories of the author. CHT1 is present on the pre-synaptic terminal of cholinergic neurons, and takes up choline which
HIGH-AFFINITY RECEPTOR-MEDIATED INTERNALIZATION AND DEGRADATION OF INTERLEUKIN 2 IN HUMAN T
"... Interleukin 2 is a single polypeptide that functions as a growth factor for T and B cells (1-7). The cell growth signal induced by IL-2 is transduced via specific receptors on the cell surface (8). Recently, two distinct IL-2-R with high and low affinities for IL-2 were identified in human T and B c ..."
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Interleukin 2 is a single polypeptide that functions as a growth factor for T and B cells (1-7). The cell growth signal induced by IL-2 is transduced via specific receptors on the cell surface (8). Recently, two distinct IL-2-R with high and low affinities for IL-2 were identified in human T and B
Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial
, 2002
"... Aripiprazole is the first next-generation atypical antipsychotic with a mechanism of action that differs from currently marketed typical and atypical antipsychotics. Aripiprazole displays prop-erties of an agonist and antagonist in animal models of dopa-minergic hypoactivity and hyperactivity, respe ..."
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, respectively. This study examined the interactions of aripiprazole with a single population of human D2 receptors to clarify further its pharma-cologic properties. In membranes prepared from Chinese ham-ster ovary cells that express recombinant D2L receptors, aripi-prazole bound with high affinity to both
The Link between Inactivation and High-Affinity Block of hERG1 Channels
, 2015
"... Block of human ether-à-go-go–related gene 1 (hERG1) K1 channels by many drugs delays cardiac repolarization, pro-longs QT interval, and is associated with an increased risk of cardiac arrhythmia. Preferential block of hERG1 channels in an inactivated state has been assumed because inactivation defic ..."
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inactivation. Concatenated hERG1 tetramers containing four wild-type subunits exhibited high-affinity block by cisapride, dofetilide, and MK-499, similar to wild-type channels formed from hERG1 monomers. A single S620T subunit within a tetramer was sufficient to fully disrupt inactivation gating, whereas S631A
ARTICLE Engineering a High-Affinity Scaffold for Non-Chromatographic Protein Purification
"... ABSTRACT: While protein purification has long been dom-inated by standard chromatography, the relatively high cost and complex scale-up have promoted the development of alternative non-chromatographic separation methods. Here we developed a new non-chromatographic affinity method for the purificatio ..."
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–dockerin pairs, which are high-affinity protein complex responsible for the formation of cellulo-some in anaerobic bacteria, were used as the model. By exploiting the highly specific interaction between the dock-erin and cohesin domain from Clostridium thermocellum and the reversible aggregation property of ELP
ldentification and Characterization of High-Affinity Binding Sites for lnositol Trisphosphate in Red Seet
"... lnositol lP,btrisphosphate (InsP3) is thought to play a primary role in intracellular Ca2+ mobilization during signal trans-duction in plant cells. Although InsP3-elicited Ca2+ release across the vacuolar membrane has been demonstrated in a variety of species, little is known of the properties of th ..."
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of the putative InsP3 receptor. Using a 3H-lnsP3 ligand-displacement assay with detergent-solubilized microsomes from the storage root of red beet, we determined that lnsP3 binds specifi-Cally to a single class of high-affinity binding sites (dissociation constant [Kd] = 121 f 10 nM) with an estimated receptor
High-Affinity Binding of Clostridium perfrngens Epsilon-Toxin to Rat Brain
, 1991
"... 125I-epsilon-toxin showed high affinity to rat brain homogenates and synaptosomal membrane fractions, having single binding phases with dissociation constants (Kds) of 2.5 and 3.3 nM, respectively. Treatment of synaptosomal membrane fractions with pronase and neuraminidase lowered the binding of the ..."
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125I-epsilon-toxin showed high affinity to rat brain homogenates and synaptosomal membrane fractions, having single binding phases with dissociation constants (Kds) of 2.5 and 3.3 nM, respectively. Treatment of synaptosomal membrane fractions with pronase and neuraminidase lowered the binding
Properties of the high-affinity single-stranded DNA binding state of the Escherichia coli recA protein. Biochemistry 27:1205–1212
, 1988
"... ABSTRACT: The properties of the high-affinity single-stranded DNA (ssDNA) binding state of Escherichia coli recA protein have been studied. We find that all of the nucleoside triphosphates that are hydrolyzed by recA protein induce a high-affinity ssDNA binding state. The effect of ATP binding to re ..."
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Cited by 5 (3 self)
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ABSTRACT: The properties of the high-affinity single-stranded DNA (ssDNA) binding state of Escherichia coli recA protein have been studied. We find that all of the nucleoside triphosphates that are hydrolyzed by recA protein induce a high-affinity ssDNA binding state. The effect of ATP binding
Spectroscopic Characterization of a High-Affinity Calmodulin-Target Peptide Hybrid Molecule†
, 1995
"... ABSTRACT: We describe the properties of a hybrid protein comprising the full length of the Xenopus laeVis calmodulin sequence, followed by a pentapeptide linker (GGGGS), and residues 3-26 of M13, the calmodulin binding region of skeletal muscle myosin light chain kinase. The properties of the hybrid ..."
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of the single tryptophan residue at position 4 in the M13 sequence, and in the accessibility of this tryptophan residue to acrylamide quenching. These changes are consistent with the tryptophan residue being immobilized in a hydrophobic environment and with the hybrid protein adopting a more R-helical structure
Printed:n U.S.A Identification and Characterization of a High-Affinity
, 1996
"... A single class of high affinity leukotriene B4 (LTB4) receptors has been identified on the surface of guinea pig peritoneal exudate T lymphocytes. The Kd of these receptors is 1.6 nM, with a BmHE of 25.2 fmoVl O cells (1 500 sites/cell). Receptor binding activity can be blocked by specific LTB4 rec ..."
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A single class of high affinity leukotriene B4 (LTB4) receptors has been identified on the surface of guinea pig peritoneal exudate T lymphocytes. The Kd of these receptors is 1.6 nM, with a BmHE of 25.2 fmoVl O cells (1 500 sites/cell). Receptor binding activity can be blocked by specific LTB4
Results 11 - 20
of
256
