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Results 1 - 10
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7,605
Positional stability of single double-strand breaks in mammalian cells
- Nat. Cell Biol
, 2007
"... mammalian cells ..."
ATM activation by DNA double-strand breaks through
- the Mre11-Rad50-Nbs1 complex. Science. 2005; 308:551–4. [PubMed: 15790808
"... The ataxia-telangiectasia mutated (ATM) kinase signals the presence of DNA double-strand breaks in mammalian cells by phosphorylating proteins that initiate cell-cycle arrest, apoptosis, and DNA repair. We show that the Mre11-Rad50-Nbs1 (MRN) complex acts as a double-strand break sensor for ATM and ..."
Abstract
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Cited by 136 (0 self)
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was essential for ATM stimulation, which is consistent with the central role of single-stranded DNA as an evolutionarily conserved signal for DNA damage. In mammalian cells, DNA double-strand breaks trigger activation of the ataxia-telangiectasia mutated (ATM) protein kinase, which phos-phorylates downstream
Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break
"... In budding yeast, a single double-strand break (DSB) triggers extensive ATM (Tel1) and ATR (Mec1)-dependent phosphorylation of histone H2A (γ-H2AX) around the DSB. We describe Mec1- and Tel1-dependent phosphorylation of γ-H2B at H2B-T129. γ-H2B formation is impaired by γ-H2AX and its binding partner ..."
Abstract
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Cited by 2 (1 self)
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In budding yeast, a single double-strand break (DSB) triggers extensive ATM (Tel1) and ATR (Mec1)-dependent phosphorylation of histone H2A (γ-H2AX) around the DSB. We describe Mec1- and Tel1-dependent phosphorylation of γ-H2B at H2B-T129. γ-H2B formation is impaired by γ-H2AX and its binding
A Model of Saliency-based Visual Attention for Rapid Scene Analysis
, 1998
"... A visual attention system, inspired by the behavior and the neuronal architecture of the early primate visual system, is presented. Multiscale image features are combined into a single topographical saliency map. A dynamical neural network then selects attended locations in order of decreasing salie ..."
Abstract
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Cited by 1748 (72 self)
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A visual attention system, inspired by the behavior and the neuronal architecture of the early primate visual system, is presented. Multiscale image features are combined into a single topographical saliency map. A dynamical neural network then selects attended locations in order of decreasing
Efficient dispersal of information for security, load balancing, and fault tolerance
- Journal of the ACM
, 1989
"... Abstract. An Information Dispersal Algorithm (IDA) is developed that breaks a file F of length L = ( F ( into n pieces F,, 1 5 i 5 n, each of length ( F, 1 = L/m, so that every m pieces suffice for reconstructing F. Dispersal and reconstruction are computationally efficient. The sum of the lengths ..."
Abstract
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Cited by 561 (1 self)
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Abstract. An Information Dispersal Algorithm (IDA) is developed that breaks a file F of length L = ( F ( into n pieces F,, 1 5 i 5 n, each of length ( F, 1 = L/m, so that every m pieces suffice for reconstructing F. Dispersal and reconstruction are computationally efficient. The sum of the lengths
CIL: Intermediate language and tools for analysis and transformation of C programs
- In International Conference on Compiler Construction
, 2002
"... Abstract. This paper describes the CIntermediate Language: a highlevel representation along with a set of tools that permit easy analysis and source-to-source transformation of C programs. Compared to C, CIL has fewer constructs. It breaks down certain complicated constructs of C into simpler ones, ..."
Abstract
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Cited by 533 (11 self)
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Abstract. This paper describes the CIntermediate Language: a highlevel representation along with a set of tools that permit easy analysis and source-to-source transformation of C programs. Compared to C, CIL has fewer constructs. It breaks down certain complicated constructs of C into simpler ones
Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules.
- Science
, 1996
"... ..."
Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair
"... During meiosis, self-inflicted DNA double-strand breaks (DSBs) are created by the protein Spo11 and repaired by homologous recombination leading to gene conversions and crossovers. Crossover formation is vital for the segregation of homologous chromosomes during the first meiotic division and requir ..."
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Cited by 4 (1 self)
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During meiosis, self-inflicted DNA double-strand breaks (DSBs) are created by the protein Spo11 and repaired by homologous recombination leading to gene conversions and crossovers. Crossover formation is vital for the segregation of homologous chromosomes during the first meiotic division
Bidirectional resection of DNA double-strand breaks by
- Mre11 and Exo1. Nature 2011
"... Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires resection of 5′-termini to generate 3′-single-strand DNA tails1. Key components of this reaction are Exonuclease 1 and the bifunctional endo/exonuclease, Mre112-4. Mre11 endonuclease activity is critical when DSB ter ..."
Abstract
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Cited by 11 (0 self)
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Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires resection of 5′-termini to generate 3′-single-strand DNA tails1. Key components of this reaction are Exonuclease 1 and the bifunctional endo/exonuclease, Mre112-4. Mre11 endonuclease activity is critical when DSB
Megabase chromatin domains involved in DNA double-strand breaks in vivo
- J. Cell
, 1999
"... Abstract. The loss of chromosomal integrity from DNA double-strand breaks introduced into mammalian cells by ionizing radiation results in the specific phosphorylation of histone H2AX on serine residue 139, yielding a specific modified form named �-H2AX. An antibody prepared to the unique region of ..."
Abstract
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Cited by 203 (2 self)
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Abstract. The loss of chromosomal integrity from DNA double-strand breaks introduced into mammalian cells by ionizing radiation results in the specific phosphorylation of histone H2AX on serine residue 139, yielding a specific modified form named �-H2AX. An antibody prepared to the unique region
Results 1 - 10
of
7,605
