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A simple method for displaying the hydropathic character of a protein

by Jack Kyte, Russell, F. Doolittle - Journal of Molecular Biology , 1982
"... A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised. For this purpose, a hydropathy scale has been composed wherein the hydrophilic and hydrophobic properties of each of the 20 amino acid side-chains is tak ..."
Abstract - Cited by 2287 (2 self) - Add to MetaCart
. The consecutive scores are plotted from the amino to the carboxy terminus. At the same time, a midpoint line is printed that corresponds to the grand average of the hydropathy of the amino acid compositions found in most of the sequenced proteins. In the case of soluble, globular proteins there is a remarkable

Worst-case equilibria

by Elias Koutsoupias, Christos Papadimitriou - IN PROCEEDINGS OF THE 16TH ANNUAL SYMPOSIUM ON THEORETICAL ASPECTS OF COMPUTER SCIENCE , 1999
"... In a system in which noncooperative agents share a common resource, we propose the ratio between the worst possible Nash equilibrium and the social optimum as a measure of the effectiveness of the system. Deriving upper and lower bounds for this ratio in a model in which several agents share a ver ..."
Abstract - Cited by 847 (17 self) - Add to MetaCart
very simple network leads to some interesting mathematics, results, and open problems.

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

by Shao-en Ong, Blagoy Blagoev, Irina Kratchmarova, Dan Bach Kristensen, Akhilesh P, Matthias Mann - Mol. Cell. Proteomics , 2002
"... The abbreviations used are: SILAC: Stable isotope labeling by amino acids in cell culture, 2DE: two dimensional (isoelectric focusing/SDS-PAGE) gel electrophoresis: ICATTM: isotope-coded affinity tag; MS: mass spectrometry; MALDI-TOF: matrix assisted laser desorption ionization-time of flight; PMF: ..."
Abstract - Cited by 595 (23 self) - Add to MetaCart
. Mammalian cell lines are grown in media lacking a standard essential amino acid but supplemented with a non-radioactive, isotopically labeled form of that amino acid, in this case deuterated leucine (Leu-d3). We find that growth of cells maintained in these media is no different from growth in normal media

Contour Tracking By Stochastic Propagation of Conditional Density

by Michael Isard, Andrew Blake , 1996
"... . In Proc. European Conf. Computer Vision, 1996, pp. 343--356, Cambridge, UK The problem of tracking curves in dense visual clutter is a challenging one. Trackers based on Kalman filters are of limited use; because they are based on Gaussian densities which are unimodal, they cannot represent s ..."
Abstract - Cited by 661 (23 self) - Add to MetaCart
simultaneous alternative hypotheses. Extensions to the Kalman filter to handle multiple data associations work satisfactorily in the simple case of point targets, but do not extend naturally to continuous curves. A new, stochastic algorithm is proposed here, the Condensation algorithm --- Conditional

Cognitive networks

by Ryan W. Thomas, Luiz A. DaSilva, Allen B. MacKenzie - IN PROC. OF IEEE DYSPAN 2005 , 2005
"... This paper presents a definition and framework for a novel type of adaptive data network: the cognitive network. In a cognitive network, the collection of elements that make up the network observes network conditions and then, using prior knowledge gained from previous interactions with the network ..."
Abstract - Cited by 1106 (7 self) - Add to MetaCart
control and feedback. The paper concludes by presenting a simple case study to illustrate a cognitive network and its framework.

Transformation-Based Error-Driven Learning and Natural Language Processing: A Case Study in Part-of-Speech Tagging

by Eric Brill - Computational Linguistics , 1995
"... this paper, we will describe a simple rule-based approach to automated learning of linguistic knowledge. This approach has been shown for a number of tasks to capture information in a clearer and more direct fashion without a compromise in performance. We present a detailed case study of this learni ..."
Abstract - Cited by 924 (8 self) - Add to MetaCart
this paper, we will describe a simple rule-based approach to automated learning of linguistic knowledge. This approach has been shown for a number of tasks to capture information in a clearer and more direct fashion without a compromise in performance. We present a detailed case study

Convex Position Estimation in Wireless Sensor Networks

by Lance Doherty , Kristofer S. J. Pister , Laurent El Ghaoui
"... A method for estimating unknown node positions in a sensor network based exclusively on connectivity-induced constraints is described. Known peer-to-peer communication in the network is modeled as a set of geometric constraints on the node positions. The global solution of a feasibility problem fo ..."
Abstract - Cited by 493 (0 self) - Add to MetaCart
respectively, though the methods presented are not limited to these simple cases.

Making the Simple Case Simple

by Michael L. Scott , 2009
"... With the proliferation of multicore processors, and the anticipation of “many-core, ” it has become commonplace to predict dire consequences if researchers fail to make it easy for rank-and-file programmers to write correct, efficient parallel code. Certainly anyone who has taught traditional concur ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
With the proliferation of multicore processors, and the anticipation of “many-core, ” it has become commonplace to predict dire consequences if researchers fail to make it easy for rank-and-file programmers to write correct, efficient parallel code. Certainly anyone who has taught traditional concurrency knows that students have great difficulty with the subject. Much of the pedagogical problem, I believe, stems from a tendency to introduce material in the way it developed historically, starting with data races and the implementation of mutual exclusion (and today including, by necessity, memory consistency models). In the “real world, ” only concurrency wizards introduce low-level data races into their code on purpose. Above the level of wizards, there would seem

Option Pricing: A Simplified Approach

by John C. Cox, Stephen A. Ross, Mark Rubinstein - Journal of Financial Economics , 1979
"... This paper presents a simple discrete-time model for valumg optlons. The fundamental econonuc principles of option pricing by arbitrage methods are particularly clear In this setting. Its development requires only elementary mathematics, yet it contains as a special limiting case the celebrated Blac ..."
Abstract - Cited by 1016 (10 self) - Add to MetaCart
This paper presents a simple discrete-time model for valumg optlons. The fundamental econonuc principles of option pricing by arbitrage methods are particularly clear In this setting. Its development requires only elementary mathematics, yet it contains as a special limiting case the celebrated

Maximum Likelihood Linear Transformations for HMM-Based Speech Recognition

by M.J.F. Gales - COMPUTER SPEECH AND LANGUAGE , 1998
"... This paper examines the application of linear transformations for speaker and environmental adaptation in an HMM-based speech recognition system. In particular, transformations that are trained in a maximum likelihood sense on adaptation data are investigated. Other than in the form of a simple bias ..."
Abstract - Cited by 570 (68 self) - Add to MetaCart
of the constrained model-space transform from the simple diagonal case to the full or block-diagonal case. The constrained and unconstrained transforms are evaluated in terms of computational cost, recognition time efficiency, and use for speaker adaptive training. The recognition performance of the two model
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