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Results 11 - 20
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12,379
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
- Dev. Biol
, 1999
"... lin-4 encodes a small RNA that is complementary to sequences in the 3 � untranslated region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of LIN-14 protein. This repression is essential for the proper timing of numerous events of Caenorhabditis elegans larval develop ..."
Abstract
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Cited by 255 (7 self)
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lin-4 encodes a small RNA that is complementary to sequences in the 3 � untranslated region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of LIN-14 protein. This repression is essential for the proper timing of numerous events of Caenorhabditis elegans larval
The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum
, 2003
"... Plasmodium falciparum is the causative agent of the most burdensome form of human malaria, affecting 200–300 million individuals per year worldwide. The recently sequenced genome of P. falciparum revealed over 5,400 genes, of which 60 % encode proteins of unknown function. Insights into the biochemi ..."
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Cited by 213 (12 self)
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into the biochemical function and regulation of these genes will provide the foundation for future drug and vaccine development efforts toward eradication of this disease. By analyzing the complete asexual intraerythrocytic developmental cycle (IDC) transcriptome of the HB3 strain of P. falciparum, we demonstrate
B: Ribo-gnome: the big world of small RNAs
- Science
"... Small RNA guides—microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length—shape diverse cellular pathways, from chromosome architecture to stem cell maintenance. Fifteen years after the discovery of RNA silencing, we are only just beginning to u ..."
Abstract
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Cited by 231 (0 self)
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Small RNA guides—microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length—shape diverse cellular pathways, from chromosome architecture to stem cell maintenance. Fifteen years after the discovery of RNA silencing, we are only just beginning
High sensitivity mapping of methylated cytosines
- Nucl. Acids Res
, 1994
"... An understanding of DNA methylation and its potential role in gene control during development, aging and cancer has been hampered by a lack of sensitive methods which can resolve exact methylation patterns from only small quantities of DNA. We have now developed a genomic sequencing technique which ..."
Abstract
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Cited by 222 (4 self)
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, to permit methylation mapping of single genes from small amounts of genomic DNA, readily available from germ cells and early developmental stages.
Polycomb-Mediated Gene Silencing in
"... Polycomb group (PcG) proteins are conserved chromatin regulators involved in the control of key developmental programs in eukaryotes. They collectively provide the tran-scriptional memory unique to each cell identity by maintain-ing transcriptional states of developmental genes. PcG proteins form mu ..."
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G-mediated gene si-lencing has been extensively investigated in efforts to un-derstand molecular mechanisms underlying developmental programs in eukaryotes. Here, we describe our current knowledge on PcG-mediated gene repression which dic-tates developmental programs by dynamic layers of regula-tory activities
HY: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
- Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang
"... Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood. Here we characterize the transcriptional landscape of the four human HOX loci at five base pair resolution in 11 anatomic sites and identify 231 HOX ncRNAs that extend known transcribed regions by more than 30 kil ..."
Abstract
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Cited by 194 (3 self)
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silencing at a distance; these results have broad implications for gene regulation in development and disease states.
Genomic Cis-regulatory logic: experimental and computational analysis of a sea urchin gene
- Science
, 1998
"... The genomic regulatory network that controls gene expression ultimately determines form and function in each species. The operational nature of the regulatory programming specified in cis-regulatory DNA sequence was determined from a detailed functional analysis of a sea urchin control element that ..."
Abstract
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Cited by 192 (2 self)
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that directs the expression of a gene in the endoderm during development. Spatial expression and repression, and the changing rate of transcription of this gene, are mediated by a complex and extended cis-regulatory system. The system may be typical of developmental cis-regulatory apparatus. All of its
Endogenous and silencing-associated small RNAs in plants
- Downloaded from http://nar.oxfordjournals.org/ at Pennsylvania State University on February 23, 2013 Acids Research
, 2002
"... A large set of endogenous small RNAs of predominantly 21 to 24 nucleotides was identified in Arabidopsis. These small RNAs resembled micro-RNAs from animals and were similar in size to small interfering RNAs that accumulated during RNA silencing triggered by multiple types of inducers. Among the 125 ..."
Abstract
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Cited by 72 (6 self)
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A large set of endogenous small RNAs of predominantly 21 to 24 nucleotides was identified in Arabidopsis. These small RNAs resembled micro-RNAs from animals and were similar in size to small interfering RNAs that accumulated during RNA silencing triggered by multiple types of inducers. Among
A Taxonomy for Artificial Embryogeny
, 2003
"... A major challenge for evolutionary computation is to evolve phenotypes such as neural networks, sensory systems, or motor controllers at the same level of complexity as found in biological organisms. In order to meet this challenge, many researchers are proposing indirect encodings, that is, evoluti ..."
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Cited by 199 (51 self)
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, evolutionary mechanisms where the same genes are used multiple times in the process of building a phenotype. Such gene reuse allows compact representations of very complex phenotypes. Development is a natural choice for implementing indirect encodings, if only because nature itself uses this very process
Results 11 - 20
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12,379
