could facilitate the development of novel therapies to combat these diseases. In par-ticular, mismatch repair activity could potentially be used to repair pathogenic mtDNA mutations exist-ing in the heteroplasmic state if heteroduplexes could be generated. To date, however, there has been no compelling

The online version of this article, along with updated information and services, is located on the

repair activity leading to microsatellite instability

by transcriptional and post-transcriptional control of the XPA protein

Loss of DNA mismatch repair (MMR) function leads to the development and progression of certain cancers. Currently, assays for DNA MMR activity involve the use of cell extracts and are technically challenging and costly. Here, we report a rapid, less laborintensive method that can quantitatively

, the exact repair mechanism is still unclear. In this study, we examine whether the repair activity level for 8-hydroxyguanine, one of the major forms of oxidative DNA damage, depends on the sequence of the substrate DNA. We prepared six different oligonucleotides containing 8-hydroxyguanine as substrates

The effect of funding scheme on the performance of

excision repair activity

deficient In both of these oxidation repair enzymes, Mg++-dependent 3"-PGA dlesterase was detected at 3 % the level found in wild-type bacteria. Gel filtration fractionated this residual diesterase activity into two peaks of Mr 40,000-52,000 (Pool A) and Mr 22,000-30,000 (Pool B) with differing

, we investigated whether the activity of the DNA repair enzyme 8-oxoguanine DNA N-glycosylase (OGG), which repairs the oxidative DNA lesion 8-oxoguanine, is associated with lung cancer. Methods: We conducted a molecular epidemiologic case–control study that included 68 case patients with non