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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13

by Matt Kaeberlein, Mitch Mcvey, Leonard Guarente , 1999
"... The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short life span of a sir3 or sir4 mutant is due to the simultaneous expression of a and � mating-type informati ..."
Abstract - Cited by 208 (13 self) - Add to MetaCart
-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of extrachromosomal rDNA circles. The short life span of a sir2 mutant also reveals a direct failure to repress recombination generated by the Fob1p-mediated replication block in the rDNA. Sir2p is a

Failure

by Yves Schutz Jp Flatt
"... of dietary fat intake to promote fat oxidation: a factor favoring the development of obesity13 ..."
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of dietary fat intake to promote fat oxidation: a factor favoring the development of obesity13

Bank regulation and supervision: what works best?

by James R. Barth, Gerard Caprio, Jr., Ross Levine - JOURNAL OF FINANCIAL INTERMEDIATION , 2003
"... This paper draws on our new database on bank regulation and supervision in 107 countries to assess different governmental approaches to bank regulation and supervision and to evaluate the efficacy of specific regulatory and supervisory policies. First, we assess two broad and competing theories of g ..."
Abstract - Cited by 184 (6 self) - Add to MetaCart
of government regulation: the helping-hand approach, according to which governments regulate to correct market failures, and the grabbing-hand approach, according to which governments regulate to support political constituencies. Second, we assess the impact of an extensive array of specific regulatory

Emotional responses to goal attainment: Strength of regulatory focus as moderator

by E. Tory Higgins, James Shah, Ronald Friedman - Journal of Personality and Social Psychology , 1997
"... Goals with a promotion focus versus a prevention focus are distinguished. Chronic ideal goals (hopes and aspirations) have a promotion focus, whereas ought goals (duties and responsibilities) have a prevention focus. The hypothesis that emotional responses to goal attainment vary as a function of pr ..."
Abstract - Cited by 146 (17 self) - Add to MetaCart
(i.e., success or failure) to emotional intensity (Study 4). All studies found that goal attainment yielded greater cheerfulness-dejection responses when promotion focus was stronger and greater quiescence-agitation responses when prevention focus was stronger. What makes people feel good or bad

Can the failure to punish promote cheating in mutualism?

by David P. Edwards, Felicity A. Ansell, Paul Woodcock, Tom M. Fayle, Chey V. K, Keith C. Hamer, K. C. Hamer
"... A key challenge in the study of mutualism is to understand the mechanisms that prevent cheating. In some systems, host retaliation against cheaters prevents the breakdown of cooperation. Here, we focus on the converse of this demonstration, and ask whether hosts that fail to retaliate are commonly i ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
A key challenge in the study of mutualism is to understand the mechanisms that prevent cheating. In some systems, host retaliation against cheaters prevents the breakdown of cooperation. Here, we focus on the converse of this demonstration, and ask whether hosts that fail to retaliate are commonly inhabited by cheaters. We do so using the classic antplant interaction, in which plants provide ant-housing (domatia) in return for protection from herbivores. Our model system is the rattan ant-palm Korthalsia furtadoana, which grows swollen leaf sheaths as domatia and associates with two species of obligate host-ants, Camponotus sp90 and C. sp93, and with facultative Crematogaster and ‘tramp ’ ant species. One ant-tree species is known to retaliate by tying the growth of domatia to the successful protection of new leaves, and non-protecting cheaters are rare. In contrast, K. furtadoana grows the domatium before the new leaf develops, suggesting that sanctioning may not be possible. We experimentally simulated herbivory by cutting leaves from shoots and found no difference in the mortality and growth of domatia on such ‘cheated ’ shoots than on controls, confirming that K. furtadoana cannot sanction non-protectors. We then investigated the intensity of protection that Camponotus and Crematogaster ant-symbionts provide K. furtadoana. We demonstrate that C. sp90, which only inhabit half of colonised plants, vigorously protects leaves, that C. sp93 rarely protects, and that Crematogaster never protects. We then show that plants inhabited by C. sp90 have a higher growth rate than those inhabited by C. sp93. We conclude that C. sp90 is a protection mutualist, while C. sp93 and Crematogaster are parasites, the first such demonstrations for an antpalm interaction. The presence of

Explaining the decline in coronary heart disease mortality

by Belgin Unal, Mph Julia, Alison Critchley, Dphil Simon Capewell - in England and Wales between 1981 and 2000. Circulation
"... Background—Coronary heart disease mortality rates have been decreasing in the United Kingdom since the 1970s. Our study aimed to examine how much of the decrease in England and Wales between 1981 and 2000 could be attributed to medical and surgical treatments and how much to changes in cardiovascula ..."
Abstract - Cited by 117 (19 self) - Add to MetaCart
% to secondary prevention, 13 % to heart failure treatments, 8 % to initial treatments of acute myocardial infarction, and 3% to hypertension treatments) and 58 % to population risk factor reductions (principally smoking, 48%; blood pressure, 9.5%; and cholesterol, 9.5%). Adverse trends were seen for physical

Promotes Liver Regeneration in Acute Liver Failure Rats

by Polylactic Acid-o-carboxymethylated, Chitosan Nanoparticles, Zhong Chen, Renan Chang, Weijun Guan, Hongyu Cai, Fei Tang, Wencai Zhu, Jiahui Chen
"... which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In this study, free porcine hepatocytes suspension (Group A), porcine hepatocytes embedded in collagen gel (Group B), porcine hepatocytes cultured with PLA-O-CMC nanoparticles ..."
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cultured with PLA-O-CMC nanoparticles and embedded in collagen gel can promote significantly liver regeneration in ALF rats. 1.

What it takes to do well in school and whether i’ve got it: The role of perceived control in children’s engagement and school achievement

by Ellen A. Skinner, James G. Wellborn, James P. Connell - Journal of Educational Psychology , 1990
"... A new conceptualization of perceived control was used to test a process model describing the contribution of these perceptions to school achievement for students in elementary school (N = 220). Three sets of beliefs were distinguished: (a) expectations about whether one can influence success and fai ..."
Abstract - Cited by 113 (8 self) - Add to MetaCart
and failure in school (control beliefs); (b) expectations about the strategies that are effective in producing academic outcomes; and (c) expectations about one's own capacities to execute these strategies. Correlational and path analyses were consistent with a process model which predicted that children

Promoting social interaction of children with disabilities in integrated preschools: A failure to generalize

by Joel Hundert, Anne Houghton - Exceptional Children , 1992
"... ABSTRACT.- III this studv, the Clusswide Social Skills Program (CSSP) was introduced for all children injour integrated preschool classes, and generalization of e[fecls was measured across settings and over timefor 14 children with disabilities between the ages (!f 3 and S years. Results indicated t ..."
Abstract - Cited by 8 (0 self) - Add to MetaCart
-monthfollow-up periods nor 10 another play session ill the day. Implications Fir promoting social interaction ill integrated preschool settings are discussed. o Much of the movement for mainstrearning children with disabilities is based on the compel-ling rationale of its social benefits for these chil-dren (Guralnick

Global analysis of the general stress response of Bacillus subtilis

by Anja Petersohn, Matthias Brigulla, Stefan Haas, Jörg D. Hoheisel, Abteilung Theoretische Bioinformatik, Abteilung Funktionelle Genomanalyse - J. Bacteriol , 2001
"... Gene arrays containing all currently known open reading frames of Bacillus subtilis were used to examine the general stress response of Bacillus. By proteomics, transcriptional analysis, transposon mutagenesis, and consensus promoter-based screening, 75 genes had previously been described as � B-dep ..."
Abstract - Cited by 104 (15 self) - Add to MetaCart
Gene arrays containing all currently known open reading frames of Bacillus subtilis were used to examine the general stress response of Bacillus. By proteomics, transcriptional analysis, transposon mutagenesis, and consensus promoter-based screening, 75 genes had previously been described as � B
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