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Cancer chemopreventive activity mediated by 4′-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res

by Lynda L. Song, Jerome W. Kosmeder Ii, Sang Kook Lee, Daniel Lantvit, Richard C. Moon, Robert M. Moriarty, John M. Pezzuto , 1999
"... Induction of phase II enzymes is an important mechanism of chemo-prevention. In our search for novel cancer chemopreventive agents, 4*-bromoflavone (4*BF) was found to significantly induce quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10 n ..."
Abstract - Cited by 6 (2 self) - Add to MetaCart
Induction of phase II enzymes is an important mechanism of chemo-prevention. In our search for novel cancer chemopreventive agents, 4*-bromoflavone (4*BF) was found to significantly induce quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10

Liver Genomic Responses to Ciguatoxin: Evidence for Activation of Phase I and Phase II Detoxification Pathways following an Acute Hypothermic Response in Mice

by J. Gordon, John S. Ramsdell, Frances M. Van Dolah , 2008
"... Ciguatoxins (CTX) are polyether neurotoxins that target voltage-gated sodium channels and are responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a symptomatic dose (0.26 ng/g) of the highly po ..."
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Ciguatoxins (CTX) are polyether neurotoxins that target voltage-gated sodium channels and are responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a symptomatic dose (0.26 ng/g) of the highly potent Pacific ciguatoxin-1 (P-CTX-1). At 1 h post-exposure 2.4 % of features on a 44K whole genome array were differentially expressed (p £ 0.0001), increasing to 5.2 % at 4 h and decreasing to 1.4 % by 24 h post-CTX exposure. Data were filtered (|fold change | ‡ 1.5 and p £ 0.0001 in at least one time point) and a trend set of 1550 genes were used for further analysis. Early gene expression was likely influenced prominently by an acute 4C decline in core body temperature by 1 h, which resolved by 8 h following exposure. An initial downregulation of 32 different solute carriers, many involved in sodium transport, was observed. Differential gene

Short Report: Antifilarial Activity of 1,3-Diarylpropen-1-One: Effect on Glutathione- S-Transferase, a Phase II Detoxification Enzyme

by Satish K. Awasthi, Nidhi Mishra, Eep Kumar Dixit, Alka Singh, Marshleen Yadav, Sudhanshu S. Yadav, Sushma Rathaur
"... Abstract. Chalcone derivatives were evaluated for their antifilarial activity on Setaria cervi using glutathione-S-transferase (GST) as a drug target. The compounds 1-(4-benzotriazol-1-yl-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (5), and 3-(4-methoxyphenyl)-1-(4-pyrrolidin-1-yl-phenyl) prop-2-en-1 ..."
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Abstract. Chalcone derivatives were evaluated for their antifilarial activity on Setaria cervi using glutathione-S-transferase (GST) as a drug target. The compounds 1-(4-benzotriazol-1-yl-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (5), and 3-(4-methoxyphenyl)-1-(4-pyrrolidin-1-yl-phenyl) prop-2-en-1-one (7) showed a significant suppression ( P < 0.01) in GST activity of adult female parasite extract at 3 µM concentration in vitro. However, GST activity was detected along with depletion in GSH level. Except Compounds 1 and 2, all exhibited a significant effect on the motility and viability of adult parasites. Compounds 3-(4-chlorophenyl)-1-(4-piperidin-1-yl-phenyl)prop-2-en-1-one (3), 1-(4-ben-zotriazol-1-yl-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (5), and 3-(4-methoxyphenyl)-1-(4-pyrrolidin-1-yl-phenyl) prop-2-en-1-one (7) exhibited major irreversible effects on viability and resulted in parasite death and also inhibited the GST activity by 84–100 % in vitro. We report for the first time the antifilarial activity of chalcones on GST of adult para-sites. This study also strengthens our previous findings where GST is reported as a potential drug target for antifilarials. The main problem regarding the chemotherapy of filaria-sis is that no safe and effective drug is available yet to com-bat adult human filarial worms. One of the main reasons is that filarial parasites exhibit a very strong antioxidant system, which protects them from the reactive oxygen species (ROS)

Brain magnetic resonance imaging with contrast dependent on blood oxygenation.

by S Ogawa , T M Lee , A R Kay , D W Tank - Proc. Natl. Acad. Sci. USA , 1990
"... ABSTRACT Paramagnetic deoxyhemoglobin in venous blood is a naturally occurring contrast agent for magnetic resonance imaging (MRI). By accentuating the effects of this agent through the use of gradient-echo techniques in high fields, we demonstrate in vivo images of brain microvasculature with imag ..."
Abstract - Cited by 648 (1 self) - Add to MetaCart
the vessel wall. This increase in the number of spins affected by deoxyhemoglobin is a form of amplification. When the susceptibility-induced local field differences exist within an imaging voxel, there is a resultant distribution of shifts in water resonance frequencies. In the gradient-echo method, a phase

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down-regulation by cytokines and bacterial products.J. Exp. Mecl

by Federica Sallusto, R Marina Cella, Carlo Danieli, Antonio , 1995
"... We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4 develop into dendritic cells (DCs) that are extremely efficient in presenting soluble antigens to T ceils. To identif ..."
Abstract - Cited by 334 (8 self) - Add to MetaCart
. To identify the mechanisms responsible for efficient antigen capture, we studied the endocytic capacity of DCs using fluorescein isothiocyanate--dextran, horseradish peroxidase, and lucifer yellow. We found that DCs use two distinct mechanisms for antigen capture. The first is a high level of fluid phase

ITALIAN JOURNAL OF PEDIATRICS

by Glutathione S Transferase
"... re an n TT genetic factors involved in complex pathologies such as asthma is arduous, not only because of human genetic trapolated from one ethnic group to another [3]. Phase II detoxification enzymes, particularly classes of ..."
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re an n TT genetic factors involved in complex pathologies such as asthma is arduous, not only because of human genetic trapolated from one ethnic group to another [3]. Phase II detoxification enzymes, particularly classes of

PHASE I AND PHASE II ENZYME ACTIVITIES

by Dawn Marie Penn, Quinone Reductase, Cytochrome P A, Dawn Marie Penn , 2003
"... (Under the Direction of JOAN G. FISCHER) Quercetin and genistein are flavonoids commonly found in fruits and vegetables that may protect against the development of chronic diseases, such as cancer. They protect against cellular damage, through one possible mechanism of inducing the anti-cancer Phase ..."
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-cancer Phase II detoxification enzymes without concurrently stimulating Phase I enzyme activity. The objective of this study was to determine whether quercetin and genistein increase activity of the Phase II enzymes, Glutathione-s-Transferase and Quinone Reductase, in a dose response manner while decreasing

In Defense of Nearest-Neighbor Based Image Classification

by Oren Boiman
"... State-of-the-art image classification methods require an intensive learning/training stage (using SVM, Boosting, etc.) In contrast, non-parametric Nearest-Neighbor (NN) based image classifiers require no training time and have other favorable properties. However, the large performance gap between th ..."
Abstract - Cited by 266 (2 self) - Add to MetaCart
-based image classifiers: (i) Quantization of local image descriptors (used to generate “bags-of-words”, codebooks). (ii) Computation of ‘Image-to-Image ’ distance, instead of ‘Image-to-Class ’ distance. We propose a trivial NN-based classifier – NBNN, (Naive-Bayes Nearest-Neighbor), which employs NNdistances

Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes but does not inhibit intracellular multiplication.

by Marcus A Horwitz , Samuel C Silverstein - J. Exp. Med. , 1980
"... A B S T R A C T We have studied the interaction between virulent egg yolk-grown Legionella pneumophila Philadelphia 1 and human blood monocytes in vitro. The leukocytes were cultured in antibiotic-free tissue culture medium supplemented with 15% autologous human serum. L. pneumophila multiplied sev ..."
Abstract - Cited by 241 (11 self) - Add to MetaCart
several logs, as measured by colony-forming units, when incubated with monocytes or mononuclear cells; the mid-log phase doubling time was 2 h. The level to which L. pneumophila multiplied was proportional to the number of mononuclear cells in the culture. L. pneumophila multiplied only in the adherent

Chemopreventive potential of geraniol in 7,12-dimethylbenz(a) anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice Author Details Publication Data

by S Manoharan , M Vasantha Selvan
"... Abstract The present study investigated the chemopreventive potential of geraniol, an acyclic monoterpene alcohol, by monitoring the tumor incidence and analyzing the status of phase II detoxification agents, lipid peroxidation by products and antioxidants in 7,12-dimethylbenz(a)anthracene (DMBA) i ..."
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Abstract The present study investigated the chemopreventive potential of geraniol, an acyclic monoterpene alcohol, by monitoring the tumor incidence and analyzing the status of phase II detoxification agents, lipid peroxidation by products and antioxidants in 7,12-dimethylbenz(a)anthracene (DMBA
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