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81
Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite
"... Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro-inflammatory cytokin ..."
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, soluble GP63 could use a phagocytosis-independent mechanism to enter the host cell. In support of this, disruption of macrophage lipid raft microdomains by Methyl b-Cyclodextrin (MbCD) partially inhibits the degradation of full length c-Jun. Together our
Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms
- J. Immunol
, 2000
"... Caspase activation, exposure of phosphatidylserine (PS) on the outer surface of the plasma membrane, and rapid phagocytic removal of dying cells are key features of apoptosis. Nonapoptotic/necrotic modes of death occur independent of caspase activation, but the role of phagocytosis is largely unknow ..."
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Cited by 11 (4 self)
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Caspase activation, exposure of phosphatidylserine (PS) on the outer surface of the plasma membrane, and rapid phagocytic removal of dying cells are key features of apoptosis. Nonapoptotic/necrotic modes of death occur independent of caspase activation, but the role of phagocytosis is largely
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis
- J Clin Invest
, 1975
"... ABSTRACT Human peripheral blood polymorphonu-clear leukocytes, when exposed to appropriate stimuli, generate significant amounts of superoxide anion (O2), a highly reactive molecule which is possibly involved in bacterial killing. Since the subcellular localization and mechanism of activation of °2 ..."
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Cited by 42 (3 self)
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ABSTRACT Human peripheral blood polymorphonu-clear leukocytes, when exposed to appropriate stimuli, generate significant amounts of superoxide anion (O2), a highly reactive molecule which is possibly involved in bacterial killing. Since the subcellular localization and mechanism of activation of °2
OPSONIN-INDEPENDENT LIGATION OF Fcy RECEPTORS The 3G8-bearing Receptors on Neutrophils Mediate the Phagocytosis of
"... Recognition of bacteria by phagocytes is crucial to host defenses against infection. The elimination of bacteria generally occurs by specific receptormediated endocytosis and intracellular digestion. In the immune host, phagocytosis by Fc receptors and complement receptors is mediated by the presenc ..."
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by the presence of IgG and certain complement components on the bacterial surface. In the absence of these opsonins, other mechanisms, including carbohydrate-lectin interactions and adherence-promoting receptors, provide important alternative means for recognition and ligation (1-3). Two pathways of opsonin-independent
Supplementary Material References Subscriptions Permissions Email Alerts Isoform-Specific Membrane Targeting Mechanism of Rac during Fc γR-Mediated Phagocytosis: Positive Charge-Dependent and Independent Targeting Mechanism of Rac to
, 2013
"... ml This article cites 45 articles, 27 of which you can access for free at: ..."
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ml This article cites 45 articles, 27 of which you can access for free at:
Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation
"... M.A.B. and M.N. contributed equally to this article. ABSTRACT Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstre ..."
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recruitment domain) signaling and is part of a PLY-dependent but phagocytosis-independent host response that includes the production of cytokines, including interleukin-1 beta (IL-1). LMP involves progressive and selective permeability to 40-kDa but not to 250-kDa fluores-cein isothiocyanate (FITC
Investigation of mechanisms involved in phagocytosis of
, 2002
"... Legionella pneumophila, the causative agent of Legionnaires ’ disease, is able to survive and multiply efficiently in a variety of mammalian cells. By using in vitro assays, the uptake of L. pneumophila into monocytes has shown to be mediated, at least in part, through attachment of complement-coate ..."
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-coated bacteria to complement receptors, but complement-independent phagocytosis could also be demonstrated. Since complement levels in the human lung are normally low, the role of complement-dependent phagocytosis in the pathogenesis of Legionnaires ’ disease is doubtful. However, the contribution of other
Mechanisms of lysosomal enzyme release from human leukocytes. If. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function. d
- Clin. Invest. 53:297-309. (152 THE JOURNAL OF CELL BIOLOGY . VOLUME
, 1974
"... In order to study mechanisms underlying selective enzyme release from human leukocytes during phagocytosis, the effects were studied of compounds which affect microtubule integrity or the accumulation of cyclic nucleotides. Human leukocytes selectively extrude lysosomal enzymes (,3-glucuronidase) fr ..."
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Cited by 38 (7 self)
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In order to study mechanisms underlying selective enzyme release from human leukocytes during phagocytosis, the effects were studied of compounds which affect microtubule integrity or the accumulation of cyclic nucleotides. Human leukocytes selectively extrude lysosomal enzymes (,3-glucuronidase
Cell-Matrix Entanglement and Mechanical Anchorage of Fibroblasts
- in Three-Dimensional Collagen Matrices
, 2005
"... Fibroblast-3D collagen matrix culture provides a physiologically relevant model to study cell-matrix interactions. In tissues, fibroblasts are phagocytic cells, and in culture, they have been shown to ingest both fibronectin and collagencoated latex particles. Compared with cells on collagen-coated ..."
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Cited by 15 (0 self)
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in mechanisms of adhesion for fibroblasts on coverslips versus matrices. Additional experiments confirmed this possibility. Cells were examined by scanning electron microscopy before and after trypsinization. Evidence That Anchorage of Fibroblasts to Collagen Matrices Develops an Integrin-independent
Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 2004
"... n Abstract Because of the evolutionary conservation of innate mechanisms of host defense, Drosophila has emerged as an ideal animal in which to study the genetic control of immune recognition and responses. The discovery that the Toll pathway is required for defense against fungal infection in Droso ..."
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Cited by 42 (0 self)
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, that activate responses to infection. Drosophila blood cells also contribute to host defense through phagocytosis and signaling, and may carry out a form of self-nonself recognition that is independent of microbial pattern recognition. Recent work suggests that Drosophila will be a useful model for dissecting
Results 1 - 10
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81
