clusters of gene expression profiles

NForty-three cases of melanoma occurring before age 20 years were reviewed from a twenty-one year period at a single center. Thirteen of the patients were preadolescent children, and 90 % were Caucasian. Histologic review of 39 available primary tumors showed superficial spreading and nodular types only. Thickness ranged from 0.23 mm to 5.43 mn, with a mean of 1.58 mm. Ulceration was present in 8%, necrosis in 28%, evidence of regression in 21%, and antecedent nevus in 33 % of cases. The overall 5 year survival is 79%, with a median follow-up of 42 months. There is no detectable survival difference between preadolescent children and adolescents. Several treatment failures occurred after improper biopsy and/or inaccurate original diagnosis of Spitz's nevus. Of 34 Stage I and II patients given definitive surgical treatment by the authors, the 5 year survival is 95%. Although histologic confusion with Spitz's nevi occasionally occurs, melanoma in this age group can be treated with good results. *

Serum high mobility group box-1 (HMGB1) is closely associated

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Improvement in nerve condition after plasma exchange for Guillain-Barrf syndrome. Sir,-Plasma exchange may produce clinical improvement ' 2 in cases of acute post-infectious polyneuropathy (Guillain-Barre Syndrome). We have treated a patient with this syndrome in whom improvement in nerve con-duction followed a single plasma ex-change, and preceded clinically evident improvement. A 37 year old woman developed paraesthesiae in the hands and feet 10 days after a vaginal infection,

clustering elucidates the pathological features of the individual members of each cluster. However, since the first clustering process and the second classification step, in which the features are associated with clusters, are performed independently, the initial set of clusters may omit genes

Tuberculosis (TB) remains a major global health prob- tion is 6.7 % [3].

Summary.-The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently

and pathological features of human PBC within the last 5 years. Herein, we compare the pathological features of previously reported and newly introduced novel animal models of PBC. Knowledge and understanding of the strengths and the limitations of each animal model have led to the development of promising

One of the major clinical applications of magnetic reso-nance imaging (MRI) is to detect pathological features in human body parts. While results are available in a digital format, their evaluation is performed by a trained human observer, which is still considered as the "gold standard