Cells of a normal yeast strain and of its copper-resistant substrain were more severely injured by copper treatment under sulfur deficiency than under nitrogen or carbon deficiency. Even under these starved conditions, the resistant substrain gave higher viable counts than the parent strain after

The measles virus P gene products V and C antagonize the host interferon (IFN) response, blocking both IFN signaling and production. Using Moraten vaccine strain-derived measles virus and isogenic mutants deficient for either V or C protein production (Vko and Cko, respectively), we observed

-alleles. Diffusion approximation models incorporating variation in viability among S-locus genotypes and antagonistic interactions between a new specificity and its immediate parent specificity are constructed and analyzed. Results indicate that variation in viability tends to reduce the number of specificities

-deficient E. coli strains but its MIC was increased eight-fold by magnesium supplementation. Nevertheless, an outer membrane-altered mutant DC2 was eight-fold more susceptible than its parent strain UB1005 to azithromycin, indicating that the outer membrane was a perme-ability barrier to this macrolide. A

Normal human somatic cells have a finite life span and undergo replicative senescence after a limited number of cell divisions. Erosion of telomeric DNA has emerged as a key factor in senescence, which is antagonized during cell immortalization and transformation. To clarify the involvement

than 100 /ig/ml of 8-azaguanine. The growth inhibition by 150 /ig/ml of 8-azaguanine of both AMP •deaminase negative and positive adenine auxotrophs was antagonized by guanosine but not by inosine. 2. Improved inosine producers were found at a high frequency among the mutants •derived from a parental

ABSTRACT The behavioral effects of the nonpeptidic delta opioid agonist SNC80 and a series of related piperazinyl benzamides derived from the parent compound BW373U86 were evaluated in rhesus monkeys. SNC80 (0.1-10 mg/kg) decreased response rates maintained by food-reinforcement in a dose

. These results indicate that: 1) neuronal uptake of norepinephrine appears to predominate in limiting the concentration of norepinephrine at the beta receptors so that the action of @OMTis concealed; and 2) in the absence of neuronal uptake, inhibition of COMT ap parently results in a significant increase

This paper analyses Tony Harrison’s poem V. within the context of the Miners ’ Strike (1984-85). We first give a brief outline of the history of the strike and then proceed to analyse the poem with particular regard to antagonisms (the primary significance of “V. ” is “Versus”) expressed through

In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as ‘designer drugs ’ and compared them to the parent substances via the resources of the National Institute of Mental Health Psychoactive Drug Screening Program. The ketamine