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Parental antagonism, relatedness asymmetries, and genomic imprinting

by David Haig - Proc R Soc Lond B , 1997
"... The theory of inclusive ¢tness can be modi¢ed to consider separate coe¤cients of relatedness for an indivi-dual's maternal and paternal alleles. A gene is said to have parentally antagonistic e¡ects if it has an inclusive ¢tness bene¢t when maternally derived, but an inclusive ¢tness cost when ..."
Abstract - Cited by 42 (11 self) - Add to MetaCart
paternally derived (or vice versa). Parental antagonism favours the evolution of alleles that are expressed only when maternally derived or only when paternally derived (genomic imprinting). 1.

interact to shape family life

by Joël Meunier, Mathias Kölliker, Joël Meunier, Mathias Kölliker , 2012
"... Parental antagonism and parent−offspring co-adaptation ..."
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Parental antagonism and parent−offspring co-adaptation

Specialists and generalists: The sexual ecology of the genome

by David Haig, Manus M. Patten - In , 2014
"... Sexual antagonism occurs when an allele is beneficial in one sex but costly in the other. Parental antagonism occurs when an allele is beneficial when inherited from one sex but costly when inherited from the other because of fitness interactions among kin. Sexual and parental antagonisms together d ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
Sexual antagonism occurs when an allele is beneficial in one sex but costly in the other. Parental antagonism occurs when an allele is beneficial when inherited from one sex but costly when inherited from the other because of fitness interactions among kin. Sexual and parental antagonisms together

Virus VP40 Confers Interferon Antagonism in Mouse Cells

by Alicia R. Feagins, Christopher F. Basler
"... Marburg viruses (MARVs) cause highly lethal infections in humans and nonhuman primates. Mice are not gen-erally susceptible to MARV infection; however, if the strain is first adapted to mice through serial passaging, it becomes able to cause disease in this animal. A previous study correlated change ..."
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lines, compared with the parental Ci67 VP40. Ci67 VP40 is also demonstrated to target the activation of kinase Jak1. A single change at VP40 residue 79 was found to be suf-ficient for the increased VP40 IFN antagonism. These data argue that VP40 IFN-antagonist activity plays a key role in MARV

Cockayne Syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

by Irina V. Kovtun, Kurt O. Johnson, Cynthia T. Mcmurray
"... Copyright: © Kovtun et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Δ Abstract: OGG1 and MSH2/MSH3 promot ..."
Abstract - Cited by 8 (0 self) - Add to MetaCart
‐induced deletions at CAG repeat tract. To test the role of CSB in vivo, we measured intergenerational and somatic expansion of CAG tracts in HD mice lacking CSB, OGG1, or both. We provide evidence that CSB protects CAG repeats from expansion by either active reduction of the tract length during parent

Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

by unknown authors
"... Background: ABCC1 and ABCG2 are ubiquitous ATP-binding cassette transmembrane proteins that play an important role in multidrug resistance (MDR). In this study, we evaluated the possible interaction of vandetanib, an orally administered drug inhibiting multiple receptor tyrosine kinases, with ABCC1 ..."
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and ABCG2 in vitro. Methodology and Principal Findings: MDR cancer cells overexpressing ABCC1 or ABCG2 and their sensitive parental cell lines were used. MTT assay showed that vandetanib had moderate and almost equal-potent anti-proliferative activity in both sensitive parental and MDR cancer cells

Short Communication ANTAGONISM OF DRUGS USED IN LEUKAEMIA THERAPY TO THE KILLING OF HUMAN LYMPHOBLASTOID CELLS BY

by R. M. Gledhill, M. R. Norman, The Human, Cell Line Ccrf-cem
"... was derived by Foley et al. (1965) from the peripheral blood of a patient with acute lymphoblastic leukaemia (ALL). When tested by Norman & Thompson (1977) CCRF-CEM was only partially sensitive to glucocorticoids, but Clone C7, isolated from the parental cell line, was lysed by pharmacological c ..."
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was derived by Foley et al. (1965) from the peripheral blood of a patient with acute lymphoblastic leukaemia (ALL). When tested by Norman & Thompson (1977) CCRF-CEM was only partially sensitive to glucocorticoids, but Clone C7, isolated from the parental cell line, was lysed by pharmacological

Trajectories of Children's Social Interactions With Their Infant Sibling in the First Year: A Multidimensional Approach

by Wonjung Oh , Brenda L Volling , Richard Gonzalez
"... Individual differences in longitudinal trajectories of children's social behaviors toward their infant sibling were examined simultaneously across multiple social dimensions: Positive engagement (moving toward), antagonism (moving against), and avoidance (moving away). Three distinct social pa ..."
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, and became increasingly avoidant over time. A path model, guided by a Process ϫ Person ϫ Context ϫ Time model, revealed that low parental self-efficacy heightened by parenting stress and children's dysregulated temperament was directly related to the escalating-antagonism pattern. Punitive parenting

Salt-resistant alpha-helical cationic antimicrobial peptides

by Carol Friedrich, Monisha G. Scott, Nedra Karunaratne, Hong Yan, Robert E. W. Hancock , 1999
"... Analogues based on the insect cecropin–bee melittin hybrid peptide (CEME) were studied and analyzed for activity and salt resistance. The new variants were designed to have an increase in amphipathic a-helical con-tent (CP29 and CP26) and in overall positive charge (CP26). The a-helicity of these pe ..."
Abstract - Cited by 23 (2 self) - Add to MetaCart
-helicity of these peptides was demonstrated by circular dichroism spectroscopy in the presence of liposomes. CP29 was shown to have activity against gram-negative bacteria that was similar to or better than those of the parent peptides, and CP26 had similar activity. CP29 had cytoplasmic membrane permeabilization activity

DOI 10.1007/s12124-010-9148-1 COMMENTARY Kowakare: A New Perspective on the Development

by Of Early Mother–offspring Relationship, Koichi Negayama, K. Negayama , 2010
"... # The Author(s) 2010. This article is published with open access at Springerlink.com Abstract The mother–offspring relationship has components of both positivity and negativity. Kowakare is a new concept introduced to explain an adaptive function of the negativity in the early mother-offspring relat ..."
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-offspring relationship. Kowakare is the psychosomatic development of the relationship as the process of accumulation in the otherness of offspring. Early human Kowakare has two frameworks, biological interbody antagonism and socio-cultural allomothering compensating the antagonism. Some features of feeding
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