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The OxyR Regulon in Nontypeable Haemophilus influenzae � †
, 2006
"... This article cites 90 articles, 63 of which can be accessed free ..."
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This article cites 90 articles, 63 of which can be accessed free
Haemophilus influenzae OxyR: Characterization of Its Regulation, Regulon and Role in Fitness
"... To prevent damage by reactive oxygen species, many bacteria have evolved rapid detection and response systems, including the OxyR regulon. The OxyR system detects reactive oxygen and coordinates the expression of numerous defensive antioxidants. In many bacterial species the coordinated OxyR-regulat ..."
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To prevent damage by reactive oxygen species, many bacteria have evolved rapid detection and response systems, including the OxyR regulon. The OxyR system detects reactive oxygen and coordinates the expression of numerous defensive antioxidants. In many bacterial species the coordinated Oxy
OxyR regulon controls lipid peroxidation-mediated oxidative stress in Escherichia coli
- J. Biochem. Mol. Bio
, 2002
"... Membrane lipid peroxidation processes yield products that may react with DNA and proteins to cause oxidative modifications. The oxyR gene product regulates the expression of enzymes and proteins that are needed for cellular protection against oxidative stress. Upon exposure to tert-butylhydroperoxid ..."
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radical-induced cellular damage. Also, the oxyR regulon plays an important protective role in lipid peroxidation-mediated cellular damage.
The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate
, 2000
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Purification and Characterization of the Escherichia coli OxyR Protein, the Positive Regulator for a Hydrogen Peroxide-Inducible
"... The Escherichia coli oxyR gene is required for the induction of a regulon that is inducible by hydrogen peroxide and confers resistance to oxidative stresses. We constructed a plasmid system that greatly overproduced OxyR protein and purified the protein. OxyR protein specifically bound to the upstr ..."
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The Escherichia coli oxyR gene is required for the induction of a regulon that is inducible by hydrogen peroxide and confers resistance to oxidative stresses. We constructed a plasmid system that greatly overproduced OxyR protein and purified the protein. OxyR protein specifically bound
Original article Assisted curation of regulatory interactions and growth conditions of OxyR in E. coli K-12
"... Given the current explosion of data within original publications generated in the field of genomics, a recognized bottleneck is the transfer of such knowledge into comprehensive databases. We have for years organized knowledge on transcriptional regulation re-ported in the original literature of Esc ..."
© BSRK & Springer-Verlag 2002 Control of Singlet Oxygen-induced Oxidative Damage in Escherichia coli
, 2002
"... Singlet oxygen (1O2) is a highly reactive form of molecular oxygen that may harm living systems by oxidizing critical cellular macromolecules. The oxyR gene product regulates the expression of the enzymes and proteins that are needed for cellular protection against oxidative stress. In this study, t ..."
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. However, the oxyR overexpression mutant maintained significantly higher activities of antioxidant enzymes than did the oxyR deletion mutant. These results suggest that the oxyR regulon plays an important protective role in singlet oxygen-mediated cellular damage, presumably through the protection
Genetic and Physiological Characterization of ohr, Encoding a Protein Involved in Organic Hydroperoxide Resistance
, 2000
"... The ohr (organic hydroperoxide resistance) gene product of Pseudomonas aeruginosa was essential for optimal resistance to organic hydroperoxides (OHPs) but not to hydrogen peroxide or paraquat. A �ohr mutant was hypersusceptible to OHPs in disk inhibition assays and showed enhanced killing by OHPs i ..."
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Cited by 15 (1 self)
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but not in cells treated with paraquat. An 84-bp portion upstream of the ohr mRNA start site was sufficient for ohr induction by OHPs. Thus, the ohr gene appears to encode an antioxidant enzyme that is not part of the OxyR regulon yet is specifically induced by OHPs. Aerobic respiration in Pseudomonas aeruginosa
Proline Metabolism Increases katG Expression and Oxidative Stress Resistance in Escherichia coli
"... The oxidation of L-proline to glutamate in Gram-negative bacteria is catalyzed by the proline utilization A (PutA) flavoenzyme, which contains proline dehydrogenase (PRODH) and1-pyrroline-5-carboxylate (P5C) dehydrogenase domains in a single polypeptide. Previous studies have suggested that aside fr ..."
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of katG along with several other genes involved in oxida-tive stress defense. In addition to katG, proline increased the expression of grxA (glutaredoxin 1) and trxC (thioredoxin 2) of the OxyR regulon, implicating OxyR in proline protection. Proline oxidative metabolism was shown to generate hydrogen
The Lactic Acid-Induced Acid Tolerance Response in Salmonella enterica Serovar Typhimurium Induces Sensitivity to Hydrogen Peroxide†
, 2006
"... Transcriptome analyses of Salmonella enterica serovar Typhimurium revealed that 15 genes were significantly up-regulated after 2 h of adaptation with lactic acid. cadB was the most highly up-regulated gene and was shown to be an essential component. Lactic acid-adapted cells exhibited sensitivity to ..."
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to hydrogen peroxide, likely due to down-regulation of the OxyR regulon. Salmonella enterica serovar Typhimurium employs both a logarithmic-phase acid tolerance response (ATR) and a sta-tionary-phase ATR to cope with acid stress (23). The logarith-mic-phase HCl-induced ATR requires both pre- and post
Results 1 - 10
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15
