then induce DNA damage in epidermal cells. Macrophages cocultured with target cells and TPA induce oxidized thymine bases in the target cells. This process is inhibited by both catalase and inhibitors of lipoxygenases, suggesting the involvement of both H202 and oxidized lipid products. Furthermore

ABSTRACT Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2�deoxyguanosine

Copyright Summary © 200? In JCBN the trend of biological science after the completion of the human genome project, appreciation of an organism as a system rather than the sum of many molecular functions is necessary. On the investigation of DNA damage and repair, therefore, the orientation toward

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Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high pen-etrance. We investigated whether rare inherited variants in other oxidative DNA damage repair genes predisposed to CRC. Single marker

Exposure to lead (Pb) and the developmental origin of

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TITLE: An examination of the response of mammalian cells to oxidative DNA damage in relation to ageing and neurodegeneration using recombinant adenovirus vectors PAGES: xvii, 251

Several teratogenic agents, including ionizing radiation and xenobiotics such as phenytoin, benzo[a]pyrene, thalidomide, and methamphet-amine, can initiate the formation of reactive oxygen species (ROS) that oxidatively damage cellular macromolecules including DNA. Oxidative DNA damage

by the oxidation of ascorbic acid and the effect of 50 Hz, 0.3 mT electromagnetic fields on the oxidative DNA damage has been investigated. The results of the study showed that extremely low-frequency electromagnetic fields enhanced the effect of oxidative stress on DNA damage and supported the idea obtained from