The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes

from peptides obtained from the enzymatically digested total proteins of E. coli and S. cerevisiae cells allowed matchmg of the spectra to amino acid sequences within proteins of these organisms. The approach described in this manuscript provides a convenient method to interpret tandem mass spectra

Miller [12] for a general discussion and bibliography). Events ordered in time are particularly amenable to informational analysis; thus language sequences are being extensively studied, and other sequences, such as those of music, plainly invite research. In this paper I shall indicate some of the ways

Imagine a video taken on a sunny beach, can a computer automatically tell what is happening in the scene? Can it identify different human activities in the video, such as water surfing, people walking and lying on the beach? To automatically classify or localize different actions in video sequences

l findings are applicable to automatic database searches. Keywords: alignment quality analysis/evolutionary conservation/ genome analysis/protein sequence alignment/sequence space hopping Introduction Protein sequence alignments in twilight zone Protein sequences fold into unique three

metabolic pathways and some of the known regulatory pathways. The pathway information is also represented by the ortholog group tables summarizing orthologous and paralogous gene groups among different organisms. KEGG maintains the GENES database for the gene catalogs of all organisms with complete genomes

A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting proteins have homologs in another organism fused into a single protein chain. Searching sequences from many genomes revealed 6809 such putative

Policy makers at all levels of decision making in organizations use multiple criteria to analyze their complex problems. Multicriteria thinking is used formally to facilitate their decision making. Through trade-offs it clarifies the advantages and disadvantages of policy options under

. The genome sequences of humans and several model organisms have established a nearly complete list of the genes required to

ms. For a copy of the program and documentation for UNIX systems, please contact xliu@smi.stanford.edu. 1 Introduction Over the last ten years, genomic sequencing has started in over 600 organisms, and over 50 complete genomes are sequenced. The DNA microarray technology permits the measurement