Results 1 - 10 of 1,185

The isolated N terminus of Ring1B is awell-folded, monomeric fragment with native-like structure

by Ana Isabel Martı́nez-gómez, Ra Villegas, David Aguado-llera, Julio Bacarizo, Miguel Vidal, Jose ́ L. Neira , 2013
"... The Polycomb group (PcG) proteins assemble into Polycomb repressive complexes (PRCs), PRC1 and PRC2, which act as general transcriptional repressors. PRC1 comprises a variety of biochemical entities endowed with histone H2A monoubi-quitylation activity conferred by really interesting new gene (RING) ..."
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contains the 41-residue-long RING finger motif, and flanking sequences that form an interacting platform for PcG and non-PcG proteins. We found that the N-Ring1B is a well-folded, monomeric fragment, with native-like structure which unfolds irreversibly. The protein is capable of binding to an ubiquitin

Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions

by Kim T. Simons, Charles Kooperberg, Enoch Huang, David Baker - J. MOL. BIOL , 1997
"... We explore the ability of a simple simulated annealing procedure to assemble native-like structures from fragments of unrelated protein structures with similar local sequences using Bayesian scoring functions. Environment and residue pair specific contributions to the scoring functions appear as the ..."
Abstract - Cited by 393 (70 self) - Add to MetaCart
We explore the ability of a simple simulated annealing procedure to assemble native-like structures from fragments of unrelated protein structures with similar local sequences using Bayesian scoring functions. Environment and residue pair specific contributions to the scoring functions appear

unknown title

by Eur Biophys J, Piotr Kaczka, Maria Winiewska, Igor Zhukov, Krystyna Bolewska, Andrzej Ejchart
"... The TFE‑induced transient native‑like structure of the intrinsically disordered σ 704 domain of Escherichia coli RNA polymerase ..."
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The TFE‑induced transient native‑like structure of the intrinsically disordered σ 704 domain of Escherichia coli RNA polymerase

FOR THE RECORD

by Scott A. Ross, Catherine A. Sarisky, Alyce Su, Stephen L. Mayo , 2000
"... Designed protein G core variants fold to native-like structures: Sequence selection by ORBIT tolerates variation in backbone specification ..."
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Designed protein G core variants fold to native-like structures: Sequence selection by ORBIT tolerates variation in backbone specification

Improved recognition of native-like protein structures using a combination of sequence-dependent and sequence-independent features of proteins

by Kim T. Simons, Ingo Ruczinski, Charles Kooperberg, Brian A. Fox, Chris Bystroff, David Baker - Proteins , 1999
"... ABSTRACT We describe the development of a scoring function based on the decomposition P(structure0sequence) � P(sequence0structure) *P(structure), which outperforms previous scoring functions in correctly identifying native-like protein structures in large ensembles of compact decoys. The first ter ..."
Abstract - Cited by 87 (21 self) - Add to MetaCart
ABSTRACT We describe the development of a scoring function based on the decomposition P(structure0sequence) � P(sequence0structure) *P(structure), which outperforms previous scoring functions in correctly identifying native-like protein structures in large ensembles of compact decoys. The first

Distance Geometry Generates Native-Like Folds for Small Helical Proteins Using the Consensus Distances of Predicted Protein Structures

by Enoch S. Huang, Ram Samudrala, Jay W. Ponder , 1998
"... For successful ab initio protein structure prediction, a method is needed to identify native-like structures from a set containing both native and non-native protein-like conformations. In this regard, the use of distance geometry has shown promise when accurate inter-residue distances are available ..."
Abstract - Cited by 14 (8 self) - Add to MetaCart
For successful ab initio protein structure prediction, a method is needed to identify native-like structures from a set containing both native and non-native protein-like conformations. In this regard, the use of distance geometry has shown promise when accurate inter-residue distances

Guiding the Search for Native-like Protein

by Amarda Shehu, Brian Olson, Conformations An
"... Exploration In this paper we propose a robotics-inspired method to enhance sampling of native-like conformations when employing only amino-acid sequence information for a protein at hand. Computing such conformations, essential to associating structural and functional in-formation with gene sequence ..."
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Exploration In this paper we propose a robotics-inspired method to enhance sampling of native-like conformations when employing only amino-acid sequence information for a protein at hand. Computing such conformations, essential to associating structural and functional in-formation with gene

Oligomeric assembly of native-like precursors precedes amyloid formation by beta-2 microglobulin. Biochemistry

by Catherine M. Eakin, Frank J. Attenello, Charles J. Morgan, Andrew D. Miranker , 2004
"... ABSTRACT: The deposition of β-2-microglobulin (β2m) as amyloid fibers results in debilitating complications for renal failure patients who are treated by hemodialysis. In vitro, wild-type β2m can be converted to amyloid under physiological conditions by exposure to biomedically relevant concentratio ..."
Abstract - Cited by 13 (1 self) - Add to MetaCart
that oligomeric intermediates are native-like in structure. The native-like structure and discrete oligomeric size of β2m amyloid intermediates suggest that this protein forms fibrils by structural domain swapping. Amyloid fibers are highly ordered protein assemblies

Is Native-like Competence Possible in L2 Acquisition?

by Silvina Montrul And, Silvina Montrul, Roumyana Slabakova - Proceedings of the Annual Boston University Conference on Language Development , 2001
"... r, was subject to a critical period. Birdsong (1992) replicated Coppieters study with other French near-native speakers by making methodological improvements, and contrary to Coppieters, found that many near-natives performed like native speakers. However, Birdsong did not test the perfective/imper ..."
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r, was subject to a critical period. Birdsong (1992) replicated Coppieters study with other French near-native speakers by making methodological improvements, and contrary to Coppieters, found that many near-natives performed like native speakers. However, Birdsong did not test the perfective

Native-like Mean Structure in the Unfolded Ensemble of Small Proteins

by Bojan Zagrovic, Christopher D. Snow, Siraj Khaliq, Michael R. Shirts, Vijay S. Pande, Vijay S. P - J. Mol. Biol , 2002
"... this article. The number of independent structures used in these averages is shown in the t rep row. The secondary structure at t rep (SS at t rep ) refers to the fraction of the native ensemble at t rep which has 14 or more helical residues in the case of villin, four or more beta-sheet residues in ..."
Abstract - Cited by 18 (4 self) - Add to MetaCart
this article. The number of independent structures used in these averages is shown in the t rep row. The secondary structure at t rep (SS at t rep ) refers to the fraction of the native ensemble at t rep which has 14 or more helical residues in the case of villin, four or more beta-sheet residues
Results 1 - 10 of 1,185