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2,991
Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes
, 1971
"... There is accumulating evidence that the capacity of lymphocytes to bind antigen specifically (1-6) is due to Ig on the cell surface: anti-Ig causes the transformation of lymphocytes (7-12) and other changes in membrane properties (13, 14); anti-L chain and anti-Ig inhibit both binding of specific an ..."
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Cited by 31 (6 self)
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surface immunoglobulin on normal splenic lymphocytes is IgM (12, 20) or IgG (7, 21), as well as the distribution of Ig on cells (20, 21). In evaluating the above results, It should be emphasized that the methodologies used rely on the capacity of anti-Ig antibody to make effective contact with antigenic
Cell surface immunoglobulin. V. Release of cell surface immunoglobulin by mouse splenic lymphocytes
, 1972
"... We have previously described a method utilizing enzymatic radioiodination of lymphoid cells to isolate and characterize cell surface immunoglobutin (Ig) l (1) and alloantigens (2). Using this approach, it was demonstrated that Ig on nmrine splenic lymphocytes is predominantly monomeric IgM (3) and i ..."
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Cited by 8 (3 self)
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We have previously described a method utilizing enzymatic radioiodination of lymphoid cells to isolate and characterize cell surface immunoglobutin (Ig) l (1) and alloantigens (2). Using this approach, it was demonstrated that Ig on nmrine splenic lymphocytes is predominantly monomeric IgM (3
unknown title
"... Frequency and spectrum of ENU-induced mutation in the FX174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies ..."
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Frequency and spectrum of ENU-induced mutation in the FX174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies
Brief Definitive Report LYMPHOCYTE ACTIVATION BY MONOVALENT FRAGMENTS OF ANTIBODIES REACTIVE
"... The critical initial event in stimulation of lymphoid cells by specific ligands such as antigens, and relatively nonspecific ligands such as antibodies and lectins, is the binding to appropriate receptor sites on the cell surface. There is considerable evidence to suggest that in order for ligands t ..."
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that the CS-Ig fractions from normal chicken serum were mitogenic for mouse splenic lymphocytes. The availability of a mitogenic reagent that can be made monovalent provides a unique opportunity
The kinetics of cellular commitment during stimulation of lymphocytes by lectins
- J. Cell
, 1974
"... The kinetics of cellular commitment in the stimulation of lymphocytes by concanavalin A (Con A) has been analyzed by measurement of DNA synthesis, autoradiography, and histologic staining techniques. If the competitive inhibitor a-methyl-D-mannoside (aMM) is introduced into cultures of mouse spleen ..."
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Cited by 8 (1 self)
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to the lectin. The combined results indicate that mouse splenic lymphocytes are heterogeneous in their capacities to respond to Con A and that different cells require different induction periods to be stimulated.
Characterization of monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.J. Exp. Med
, 1979
"... Fc receptors 1 (FcR) recognize the Fc domain of IgG and are found on macrophages, lymphocytes, and polymorphonuclear leukocytes (for reviews see Kerbel and Davies [1] and Dickler[2]). These receptors enable the effector cells to recognize foreign antigens to which antibodies are bound and may also p ..."
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Cited by 183 (7 self)
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Fc receptors 1 (FcR) recognize the Fc domain of IgG and are found on macrophages, lymphocytes, and polymorphonuclear leukocytes (for reviews see Kerbel and Davies [1] and Dickler[2]). These receptors enable the effector cells to recognize foreign antigens to which antibodies are bound and may also
CYTOTOXIC EFFECTS OF SPLENIC ULTRAFILTRATES UPON LEUKAEMIC LYMPHOCYTES
, 1975
"... Summary.-Ultrafiltrates from spleen inhibited both DNA synthesis and the proliferation of normal lymphocytes stimulated in culture from both mouse and man without apparent cytotoxicity. However, the same doses of this spleen ultrafiltrate will kill up to two-thirds of the leukaemic lymphoblasts from ..."
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Summary.-Ultrafiltrates from spleen inhibited both DNA synthesis and the proliferation of normal lymphocytes stimulated in culture from both mouse and man without apparent cytotoxicity. However, the same doses of this spleen ultrafiltrate will kill up to two-thirds of the leukaemic lymphoblasts
Abnormal Response Induced by Pesticides on Mammalian Immune System
, 2009
"... Abstract—The environmental pollution induced by the chemical substances is regarded as a serious problem on the ecosystem. Recently, many people are interested in safety of foods. We focused on two pesticide chemicals methoxychlor and endosulfan presently used in agricultural farms in many countries ..."
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Cited by 1 (0 self)
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countries. To investigate the influence of methoxychlor and endosulfan on immunoglobulin production, human hybridoma HB4C5 cells and mouse splenic lymphocytes were cultured in the medium containing these compounds at various concentrations. Human IgM production of HB4C5 cells slightly decreased in a dose
258 Journal of Health Science, 47(3) Immunotoxicological Evaluation of Environmental Chemicals Utilizing Mouse Lymphocyte
, 2001
"... To establish a useful and convenient bioassay for evaluating immunotoxicological effects of environmental chemicals, lymphocyte mitogenesis tests of about 255 chemicals and environmental water were performed. We determined the growth-inhibitory effect of the environmental chemicals on the mouse sple ..."
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To establish a useful and convenient bioassay for evaluating immunotoxicological effects of environmental chemicals, lymphocyte mitogenesis tests of about 255 chemicals and environmental water were performed. We determined the growth-inhibitory effect of the environmental chemicals on the mouse
unknown title
"... Abstract: Hemoglobin is not normally present in sputum, urine or feces except in minute amounts. Demonstration of the presence of hemoglobin in these materials is an important diagnostic clue that usually implies bleeding within the respiratory, urinary or gastroentestinal tract, respectively. In th ..."
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. In this work, a hybridoma line secreting monoclonal antibody (Mab) highly specific for human hemoglobin A (hHbA) was generated by fusion of immunized BALB/c mouse splenic lymphocytes with non-secreting mouse myeloma cells followed by selection in hypoxanthine-aminopterin-thymidine (HAT) medium
Results 1 - 10
of
2,991
