Results 1 - 10 of 93,940

Limma: linear models for microarray data

by Gordon K. Smyth, Matthew Ritchie, Natalie Thorne, James Wettenhall, Wei Shi - Bioinformatics and Computational Biology Solutions using R and Bioconductor , 2005
"... This free open-source software implements academic research by the authors and co-workers. If you use it, please support the project by citing the appropriate journal articles listed in Section 2.1.Contents ..."
Abstract - Cited by 774 (13 self) - Add to MetaCart
This free open-source software implements academic research by the authors and co-workers. If you use it, please support the project by citing the appropriate journal articles listed in Section 2.1.Contents

Longitudinal data analysis using generalized linear models”.

by Kung-Yee Liang , Scott L Zeger - Biometrika, , 1986
"... SUMMARY This paper proposes an extension of generalized linear models to the analysis of longitudinal data. We introduce a class of estimating equations that give consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence. The estimating ..."
Abstract - Cited by 1526 (8 self) - Add to MetaCart
SUMMARY This paper proposes an extension of generalized linear models to the analysis of longitudinal data. We introduce a class of estimating equations that give consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence

Regularization paths for generalized linear models via coordinate descent

by Jerome Friedman, Trevor Hastie, Rob Tibshirani , 2009
"... We develop fast algorithms for estimation of generalized linear models with convex penalties. The models include linear regression, twoclass logistic regression, and multinomial regression problems while the penalties include ℓ1 (the lasso), ℓ2 (ridge regression) and mixtures of the two (the elastic ..."
Abstract - Cited by 724 (15 self) - Add to MetaCart
We develop fast algorithms for estimation of generalized linear models with convex penalties. The models include linear regression, twoclass logistic regression, and multinomial regression problems while the penalties include ℓ1 (the lasso), ℓ2 (ridge regression) and mixtures of the two (the

Linear models and empirical bayes methods for assessing differential expression in microarray experiments.

by Gordon K Smyth , Gordon K Smyth - Stat. Appl. Genet. Mol. Biol. , 2004
"... Abstract The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model. ..."
Abstract - Cited by 1321 (24 self) - Add to MetaCart
. The purpose of this paper is to develop the hierarchical model of Lonnstedt and Speed (2002) into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples. The model is reset in the context of general linear models with arbitrary coefficients and contrasts

Maximum Likelihood Linear Transformations for HMM-Based Speech Recognition

by M.J.F. Gales - COMPUTER SPEECH AND LANGUAGE , 1998
"... This paper examines the application of linear transformations for speaker and environmental adaptation in an HMM-based speech recognition system. In particular, transformations that are trained in a maximum likelihood sense on adaptation data are investigated. Other than in the form of a simple bias ..."
Abstract - Cited by 570 (68 self) - Add to MetaCart
bias, strict linear feature-space transformations are inappropriate in this case. Hence, only model-based linear transforms are considered. The paper compares the two possible forms of model-based transforms: (i) unconstrained, where any combination of mean and variance transform may be used, and (ii

Automatic Discovery of Linear Restraints Among Variables of a Program

by Patrick Cousot, Nicolas Halbwachs , 1978
"... The model of abstract interpretation of programs developed by Cousot and Cousot [2nd ISOP, 1976], Cousot and Cousot [POPL 1977] and Cousot [PhD thesis 1978] is applied to the static determination of linear equality or inequality invariant relations among numerical variables of programs. ..."
Abstract - Cited by 726 (43 self) - Add to MetaCart
The model of abstract interpretation of programs developed by Cousot and Cousot [2nd ISOP, 1976], Cousot and Cousot [POPL 1977] and Cousot [PhD thesis 1978] is applied to the static determination of linear equality or inequality invariant relations among numerical variables of programs.

Maximum likelihood linear regression for speaker adaptation of continuous density hidden Markov models

by C. J. Leggetter, P. C. Woodland , 1995
"... ..."
Abstract - Cited by 818 (7 self) - Add to MetaCart
Abstract not found

Eigenfaces vs. Fisherfaces: Recognition Using Class Specific Linear Projection

by Peter N. Belhumeur, João P. Hespanha, David J. Kriegman , 1997
"... We develop a face recognition algorithm which is insensitive to gross variation in lighting direction and facial expression. Taking a pattern classification approach, we consider each pixel in an image as a coordinate in a high-dimensional space. We take advantage of the observation that the images ..."
Abstract - Cited by 2310 (17 self) - Add to MetaCart
from this linear subspace. Rather than explicitly modeling this deviation, we linearly project the image into a subspace in a manner which discounts those regions of the face with large deviation. Our projection method is based on Fisher's Linear Discriminant and produces well separated classes

An analysis of transformations

by G. E. P. Box, D. R. Cox - Journal of the Royal Statistical Society. Series B (Methodological , 1964
"... In the analysis of data it is often assumed that observations y,, y,,...,y, are independently normally distributed with constant variance and with expectations specified by a model linear in a set of parameters 0. In this paper we make the less restrictive assumption that such a normal, homoscedasti ..."
Abstract - Cited by 1067 (3 self) - Add to MetaCart
In the analysis of data it is often assumed that observations y,, y,,...,y, are independently normally distributed with constant variance and with expectations specified by a model linear in a set of parameters 0. In this paper we make the less restrictive assumption that such a normal

Initial Conditions and Moment Restrictions in Dynamic Panel Data Models

by Richard Blundell, Stephen Bond - Journal of Econometrics , 1998
"... Estimation of the dynamic error components model is considered using two alternative linear estimators that are designed to improve the properties of the standard firstdifferenced GMM estimator. Both estimators require restrictions on the initial conditions process. Asymptotic efficiency comparisons ..."
Abstract - Cited by 2393 (16 self) - Add to MetaCart
Estimation of the dynamic error components model is considered using two alternative linear estimators that are designed to improve the properties of the standard firstdifferenced GMM estimator. Both estimators require restrictions on the initial conditions process. Asymptotic efficiency
Results 1 - 10 of 93,940