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The Spec# Programming System: An Overview

by Mike Barnett, K. Rustan M. Leino, Wolfram Schulte , 2004
"... Spec# is the latest in a long line of work on programming languages and systems aimed at improving the development of correct software. This paper describes the goals and architecture of the Spec# programming system, consisting of the object-oriented Spec# programming language, the Spec# compiler ..."
Abstract - Cited by 542 (50 self) - Add to MetaCart
Spec# is the latest in a long line of work on programming languages and systems aimed at improving the development of correct software. This paper describes the goals and architecture of the Spec# programming system, consisting of the object-oriented Spec# programming language, the Spec

Model-Based Clustering, Discriminant Analysis, and Density Estimation

by Chris Fraley, Adrian E. Raftery - JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION , 2000
"... Cluster analysis is the automated search for groups of related observations in a data set. Most clustering done in practice is based largely on heuristic but intuitively reasonable procedures and most clustering methods available in commercial software are also of this type. However, there is little ..."
Abstract - Cited by 573 (29 self) - Add to MetaCart
Cluster analysis is the automated search for groups of related observations in a data set. Most clustering done in practice is based largely on heuristic but intuitively reasonable procedures and most clustering methods available in commercial software are also of this type. However

MEGA5: Molecular evolutionary genetics analysis using maximum . . .

by Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar , 2011
"... Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. Here, we announce the release of Molecular Evolutionary Genetics Analysis version ..."
Abstract - Cited by 7284 (25 self) - Add to MetaCart
5 (MEGA5), which is a user-friendly software for mining online databases, building sequence alignments and phylogenetic trees, and using methods of evolutionary bioinformatics in basic biology, biomedicine, and evolution. The newest addition in MEGA5 is a collection of maximum likelihood (ML

Model checking and abstraction

by Peter J. Clarke, Djuradj Babich, Tariq M. King, B. M. Golam Kibria - ACM Transactions on Programming Languages and Systems , 1994
"... software developers are using the Java language as the language of choice on many applications. This is due to the effective use of the object-oriented (OO) paradigm to develop large software projects and the ability of the Java language to support the increasing use of web technologies in business ..."
Abstract - Cited by 742 (55 self) - Add to MetaCart
software developers are using the Java language as the language of choice on many applications. This is due to the effective use of the object-oriented (OO) paradigm to develop large software projects and the ability of the Java language to support the increasing use of web technologies in business

A taxonomy and evaluation of dense two-frame stereo correspondence algorithms.

by Daniel Scharstein , Richard Szeliski - In IEEE Workshop on Stereo and Multi-Baseline Vision, , 2001
"... Abstract Stereo matching is one of the most active research areas in computer vision. While a large number of algorithms for stereo correspondence have been developed, relatively little work has been done on characterizing their performance. In this paper, we present a taxonomy of dense, two-frame ..."
Abstract - Cited by 1546 (22 self) - Add to MetaCart
-frame stereo methods. Our taxonomy is designed to assess the different components and design decisions made in individual stereo algorithms. Using this taxonomy, we compare existing stereo methods and present experiments evaluating the performance of many different variants. In order to establish a common

Scalable molecular dynamics with NAMD.

by James C Phillips , Rosemary Braun , Wei Wang , James Gumbart , Emad Tajkhorshid , Elizabeth Villa , Christophe Chipot , Robert D Skeel , Laxmikant Kalé , Klaus Schulten - J Comput Chem , 2005
"... Abstract: NAMD is a parallel molecular dynamics code designed for high-performance simulation of large biomolecular systems. NAMD scales to hundreds of processors on high-end parallel platforms, as well as tens of processors on low-cost commodity clusters, and also runs on individual desktop and la ..."
Abstract - Cited by 849 (63 self) - Add to MetaCart
and laptop computers. NAMD works with AMBER and CHARMM potential functions, parameters, and file formats. This article, directed to novices as well as experts, first introduces concepts and methods used in the NAMD program, describing the classical molecular dynamics force field, equations of motion

Support Vector Machine Classification and Validation of Cancer Tissue Samples Using Microarray Expression Data

by Terrence S. Furey, Nello Cristianini, Nigel Duffy, David W. Bednarski, Michèl Schummer, David Haussler , 2000
"... Motivation: DNA microarray experiments generating thousands of gene expression measurements, are being used to gather information from tissue and cell samples regarding gene expression differences that will be useful in diagnosing disease. We have developed a new method to analyse this kind of data ..."
Abstract - Cited by 569 (1 self) - Add to MetaCart
are analysed. The results are comparable to those previously obtained. We show that other machine learning methods also perform comparably to the SVM on many of those datasets. Availability: The SVM software is available at http:// www. cs.columbia.edu/#bgrundy/svm. Contact: booch@cse.ucsc.edu

Model-Based Analysis of Oligonucleotide Arrays: Model Validation, Design Issues and Standard Error Application

by Cheng Li, Wing Hung Wong , 2001
"... Background: A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based expression indexes (MBEI). MBEI has standard error attached to it as a measure of ..."
Abstract - Cited by 775 (28 self) - Add to MetaCart
better ranking statistic for filtering genes. We can assign reliability indexes for genes in a specific cluster of interest in hierarchical clustering by resampling clustering trees. A software dChip implementing many of these analysis methods is made available. Conclusions: The model-based approach

Fast and accurate short read alignment with Burrows-Wheeler transform

by Heng Li, Richard Durbin - BIOINFORMATICS, 2009, ADVANCE ACCESS , 2009
"... Motivation: The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hashtable based methods has been developed, including MAQ, which is accurate, feature rich and fast enough to a ..."
Abstract - Cited by 2096 (24 self) - Add to MetaCart
Motivation: The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hashtable based methods has been developed, including MAQ, which is accurate, feature rich and fast enough

Multiobjective evolutionary algorithms: a comparative case study and the strength pareto approach

by Eckart Zitzler, Lothar Thiele - IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION , 1999
"... Evolutionary algorithms (EA’s) are often well-suited for optimization problems involving several, often conflicting objectives. Since 1985, various evolutionary approaches to multiobjective optimization have been developed that are capable of searching for multiple solutions concurrently in a singl ..."
Abstract - Cited by 813 (22 self) - Add to MetaCart
single run. However, the few comparative studies of different methods presented up to now remain mostly qualitative and are often restricted to a few approaches. In this paper, four multiobjective EA’s are compared quantitatively where an extended 0/1 knapsack problem is taken as a basis. Furthermore, we
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