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Results 1 - 10
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32,357
A simple method for displaying the hydropathic character of a protein
- Journal of Molecular Biology
, 1982
"... A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised. For this purpose, a hydropathy scale has been composed wherein the hydrophilic and hydrophobic properties of each of the 20 amino acid side-chains is tak ..."
Abstract
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Cited by 2287 (2 self)
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determined by crystallography. In the case of membrane-bound proteins, the portions of their sequences that are located within the lipid bilayer are also clearly delineated by large uninterrupted areas on the hydrophobic side of the midpoint line. As such, the membrane-spanning segment’s of these proteins
Identification of Prokaryotic and Eukaryotic Signal Peptides and Prediction of Their Cleavage Sites
, 1997
"... We have developed a new method for identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequences. The method performs significantly better than previous prediction schemes, and can easily be applied on genome-wide ..."
Abstract
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Cited by 787 (17 self)
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the protein is translocated through the membrane. The common structure of signal peptides from variou...
Rho GTPases and the actin cytoskeleton
- Science
, 1998
"... The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the b ..."
Abstract
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Cited by 615 (4 self)
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their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion. The story begins back in the early 1990s with the analysis of Rho, then a newly described member of the Ras superfamily of small guanosine triphosphatases (GTPases
The structure of the potassium channel: molecular basis of K+ conduction and selectivity
- Science
, 1998
"... The potassium channel from Streptomyces lividans is an integral membrane protein with sequence similarity to all known K1 channels, particularly in the pore region. X-ray analysis with data to 3.2 angstroms reveals that four identical subunits create an inverted teepee, or cone, cradling the selecti ..."
Abstract
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Cited by 460 (1 self)
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The potassium channel from Streptomyces lividans is an integral membrane protein with sequence similarity to all known K1 channels, particularly in the pore region. X-ray analysis with data to 3.2 angstroms reveals that four identical subunits create an inverted teepee, or cone, cradling
Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
- Cell
, 1998
"... Xu Luo, 1997); and cleavage of nuclear lamins by caspase-3 and caspase-6 may contribute to nuclear membrane breakage (Lazebnik et al., 1995). Caspases that function in the apoptotic pathway exist as inactive zymogens in the cytosol of living cells and ..."
Abstract
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Cited by 421 (3 self)
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Xu Luo, 1997); and cleavage of nuclear lamins by caspase-3 and caspase-6 may contribute to nuclear membrane breakage (Lazebnik et al., 1995). Caspases that function in the apoptotic pathway exist as inactive zymogens in the cytosol of living cells and
A hidden Markov model for predicting transmembrane helices in protein sequences
- In Proceedings of the 6th International Conference on Intelligent Systems for Molecular Biology (ISMB
, 1998
"... A novel method to model and predict the location and orientation of alpha helices in membrane- spanning proteins is presented. It is based on a hidden Markov model (HMM) with an architecture that corresponds closely to the biological system. The model is cyclic with 7 types of states for helix core, ..."
Abstract
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Cited by 373 (9 self)
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A novel method to model and predict the location and orientation of alpha helices in membrane- spanning proteins is presented. It is based on a hidden Markov model (HMM) with an architecture that corresponds closely to the biological system. The model is cyclic with 7 types of states for helix core
Cellular motility driven by assembly and disassembly of actin filaments
- Cell
"... Motile cells extend a leading edge by assembling a branched network of actin filaments that produces physical force as the polymers grow beneath the plasma membrane. A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vit ..."
Abstract
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Cited by 343 (5 self)
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Motile cells extend a leading edge by assembling a branched network of actin filaments that produces physical force as the polymers grow beneath the plasma membrane. A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process
The Pathophysiology of Mitochondrial Cell Death This copy is for your personal, non-commercial use only. clicking here.colleagues, clients, or customers by , you can order high-quality copies for yourIf you wish to distribute this article to others here.f
- JULY 2004 629 DOI: 10.1126/science.1099320 , 626 (2004);305 Science
"... In the mitochondrial pathway of apoptosis, caspase activation is closely linked to mitochondrial outer membrane permeabilization (MOMP). Numerous pro-apoptotic signal-transducing molecules and pathological stimuli converge on mitochondria to induce MOMP. The local regulation and execution of MOMP in ..."
Abstract
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Cited by 337 (2 self)
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In the mitochondrial pathway of apoptosis, caspase activation is closely linked to mitochondrial outer membrane permeabilization (MOMP). Numerous pro-apoptotic signal-transducing molecules and pathological stimuli converge on mitochondria to induce MOMP. The local regulation and execution of MOMP
Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule
- J. Mol. Biol
, 1992
"... A new strategy for predicting the topology of bacterial inner membrane proteins is proposed on the basis of hydrophobicity analysis, automatic generation of a set of possible topologies and ranking of these according to the positive-inside rule. A straightforward implementation with no attempts at o ..."
Abstract
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Cited by 275 (4 self)
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A new strategy for predicting the topology of bacterial inner membrane proteins is proposed on the basis of hydrophobicity analysis, automatic generation of a set of possible topologies and ranking of these according to the positive-inside rule. A straightforward implementation with no attempts
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
- Nat. Biotechnol
, 2001
"... We describe a largely unbiased method for rapid and large-scale proteome analysis by multidimensional liquid chromatography, tandem mass spectrometry, and database searching by the SEQUEST algorithm, named multidimensional protein identification technology (MudPIT). MudPIT was applied to the proteo ..."
Abstract
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Cited by 276 (5 self)
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in proteome analysis, including lowabundance proteins like transcription factors and protein kinases. Furthermore, we identified 131 proteins with three or more predicted transmembrane domains, which allowed us to map the soluble domains of many of the integral membrane proteins. MudPIT is useful for proteome
Results 1 - 10
of
32,357
