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Results 1 - 10
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39,536
Efficient exact stochastic simulation of chemical systems with many species and many channels
- J. Phys. Chem. A
, 2000
"... There are two fundamental ways to view coupled systems of chemical equations: as continuous, represented by differential equations whose variables are concentrations, or as discrete, represented by stochastic processes whose variables are numbers of molecules. Although the former is by far more comm ..."
Abstract
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Cited by 427 (5 self)
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common, systems with very small numbers of molecules are important in some applications (e.g., in small biological cells or in surface processes). In both views, most complicated systems with multiple reaction channels and multiple chemical species cannot be solved analytically. There are exact numerical
The serial cultivation of human diploid cell strains. Exp Cell Res
, 1961
"... ONLY limited success has been obtained in developing strains of human cells that can be cultivated for long periods of time in vitro and that still preserve the diploid chromosomal configuration [41, 47, 48, 58, 591. Indeed, heteroploidy may be a necessary corollary or even the cause of the altera-t ..."
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Cited by 497 (2 self)
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hundred have been reported in the literature, have serious limitations for many kinds of biological studies. Chief among these is the exclusion of their use for the production of human virus vaccines. This limitation is based on the supposition that such hetero-ploid cell lines, whether of normal
The embryonic cell lineage of the nematode Caenorhabditis elegans
- Dev. Biol
, 1983
"... The number of nongonadal nuclei in the free-living soil nematode Caenorhabditis elegans increases from about 550 in the newly hatched larva to about 810 in the mature hermaphrodite and to about 970 in the mature male. The pattern of cell divisions which leads to this increase is essentially invarian ..."
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Cited by 540 (19 self)
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in living nematodes. Many of the cell lineages are involved in sexual maturation. At hatching, the hermaphrodite and male are almost identical morphologically; by the adult stage, gross anatomical differences are obvious. Some of these sexual differences arise from blast cells whose division patterns
Relations between the statistics of natural images and the response properties of cortical cells
- J. Opt. Soc. Am. A
, 1987
"... The relative efficiency of any particular image-coding scheme should be defined only in relation to the class of images that the code is likely to encounter. To understand the representation of images by the mammalian visual system, it might therefore be useful to consider the statistics of images f ..."
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Cited by 831 (18 self)
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of space, spatial frequency, and orientation (Gabor-like transforms). For many classes of image, such codes will not be an efficient means of representing information. However, the results obtained with six natural images suggest that the orientation and the spatial-frequency tuning of mammalian simple
Characteristics of a human cell line transformed by DNA from human adenovirus type 5
, 1977
"... Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA. The transformed cells (designated 293 cells) exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen. Analysis of the polyp ..."
Abstract
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Cited by 676 (14 self)
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Human embryonic kidney cells have been transformed by exposing cells to sheared fragments of adenovirus type 5 DNA. The transformed cells (designated 293 cells) exhibited many of the characteristics of transformation including the elaboration of a virus-specific tumour antigen. Analysis
Apoptosis: a Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
- Br. J. Cancer
, 1972
"... Summary.-The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently program ..."
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Cited by 641 (6 self)
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by lysosomal enzymes derived from the ingesting cells. Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development. It occurs spontaneously in untreated malignant neoplasms, and participates in at least some
Implementing data cubes efficiently
- In SIGMOD
, 1996
"... Decision support applications involve complex queries on very large databases. Since response times should be small, query optimization is critical. Users typically view the data as multidimensional data cubes. Each cell of the data cube is a view consisting of an aggregation of interest, like total ..."
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Cited by 548 (1 self)
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total sales. The values of many of these cells are dependent on the values of other cells in the data cube..A common and powerful query optimization technique is to materialize some or all of these cells rather than compute them from raw data each time. Commercial systems differ mainly in their approach
Studies of transformation of Escherichia coli with plasmids
- J. Mol. Biol
, 1983
"... Factors that affect he probability of genetic transformation f Escherichia coli by plasmids have been evaluated. A set of conditions is described under which about one in every 400 plasmid molecules produces a transformed cell. These conditions include cell growth in medium containing elevated level ..."
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Cited by 1632 (1 self)
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probabilities. Non-transforming DNAs compete consistent with mass. No significant variation is observed between competing DNAs of difi~rent source, complexity, length or form. Competition with both transforming and non-transforming plasmids indicates that each cell is capable of taking up many DNA molecules
Specificity and mechanism of action of some commonly used protein kinase inhibitors
- Biochem. J
, 2000
"... The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine� threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were found to inhibit many prot ..."
Abstract
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Cited by 532 (1 self)
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The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine� threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were found to inhibit many
Taming the Underlying Challenges of Reliable Multihop Routing in Sensor Networks
- In SenSys
, 2003
"... The dynamic and lossy nature of wireless communication poses major challenges to reliable, self-organizing multihop networks. These non-ideal characteristics are more problematic with the primitive, low-power radio transceivers found in sensor networks, and raise new issues that routing protocols mu ..."
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Cited by 781 (20 self)
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with constant space regardless of cell density. We study and evaluate link estimator, neighborhood table management, and reliable routing protocol techniques. We focus on a many-to-one, periodic data collection workload. We narrow the design space through evaluations on large-scale, high-level simulations to 50
Results 1 - 10
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39,536
