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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
- Mol. Cell. Proteomics
, 2002
"... The abbreviations used are: SILAC: Stable isotope labeling by amino acids in cell culture, 2DE: two dimensional (isoelectric focusing/SDS-PAGE) gel electrophoresis: ICATTM: isotope-coded affinity tag; MS: mass spectrometry; MALDI-TOF: matrix assisted laser desorption ionization-time of flight; PMF: ..."
Abstract
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Cited by 595 (23 self)
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have shown great promise for the simultaneous and automated identification and quantitation of complex protein mixtures. Here we describe a method, termed SILAC for Stable Isotope Labeling by Amino acids in Cell culture, for the in vivo incorporation of specific amino acids into all mammalian proteins
Alternative isoform regulation in human tissue transcriptomes
- Nature
, 2008
"... Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of ..."
Abstract
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Cited by 545 (6 self)
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Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing
Analysis and prediction of mammalian protein glycation
, 2006
"... Glycation is a non-enzymatic process in which proteins react with reducing sugar molecules and thereby impair the function and change the characteristics of the proteins. Glycation is involved in diabetes and aging where accumulation of glycation products cause side effects. In the present study, we ..."
Abstract
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Cited by 3 (0 self)
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Glycation is a non-enzymatic process in which proteins react with reducing sugar molecules and thereby impair the function and change the characteristics of the proteins. Glycation is involved in diabetes and aging where accumulation of glycation products cause side effects. In the present study
with a 150-Kilodalton Mammalian Protein
, 1991
"... The CDC25 gene product of the yeast Saccharomyces cerevisiae has been shown to be a positive regulator of the Ras protein. The high degree of homology between yeast RAS and the mammalian proto-oncogene ras suggests a possible resemblance between the mammalian regulator of Ras and the regulator of th ..."
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The CDC25 gene product of the yeast Saccharomyces cerevisiae has been shown to be a positive regulator of the Ras protein. The high degree of homology between yeast RAS and the mammalian proto-oncogene ras suggests a possible resemblance between the mammalian regulator of Ras and the regulator
Human DNA methylomes at base resolution show widespread epigenomic differences.
- Nature,
, 2009
"... DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryo ..."
Abstract
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Cited by 401 (6 self)
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DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human
CORUM: The comprehensive resource of mammalian protein complexes—2009
- Nucleic Acids Research
, 2010
"... protein complexes—2009 ..."
Mammalian Protein Expression Noise: Scaling Principles and the Implications for Knockdown Experiments
"... Provided by the author(s) and University College Dublin Library in accordance with publisher policies. Please cite the published version when available. Downloaded 2016-02-19T12:30:27Z Some rights reserved. For more information, please see the item record link above. Title Mammalian protein expressi ..."
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Provided by the author(s) and University College Dublin Library in accordance with publisher policies. Please cite the published version when available. Downloaded 2016-02-19T12:30:27Z Some rights reserved. For more information, please see the item record link above. Title Mammalian protein
A Conserved Mammalian Protein Interaction Network
, 2013
"... Abstract Physical interactions between proteins mediate a variety of biological functions, including signal transduction, physical structuring of the cell and regulation. While extensive catalogs of such interactions are known from model organisms, their evolutionary histories are difficult to stud ..."
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Abstract Physical interactions between proteins mediate a variety of biological functions, including signal transduction, physical structuring of the cell and regulation. While extensive catalogs of such interactions are known from model organisms, their evolutionary histories are difficult
Results 1 - 10
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9,874
