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Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite
"... Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro-inflammatory cytokin ..."
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Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro
Expression of the peroxisome proliferator-activated receptor � (PPAR�) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
- Proc. Natl. Acad. Sci. USA
, 1998
"... (PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily to regula ..."
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Cited by 266 (7 self)
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(PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily
The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP-1
, 1993
"... Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor. We have previously shown that a fragme ..."
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Cited by 13 (2 self)
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Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor. We have previously shown that a
Antioxidant and redox regulation of gene transcription
- FASEB J
, 1996
"... ABSTRACT Reactive oxygen species (ROS) are implicated in the pathogenesis of a wide variety of human diseases. Recent evidence suggests that at moderately high concentrations, certain forms of ROS such as 11202 may act as signal transduction messengers. To develop a better understanding of the exact ..."
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Cited by 89 (2 self)
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, nuclear factor (NF) KB and activator protein (AP)-1 have been identified to be regulated by the intracellular redox state. The regulation of gene expression by
Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors
, 1999
"... We have analyzed the interleukin-4 (IL-4)-triggered mechanisms implicated in cell survival and show here that IL-4 deprivation induces apoptotic cell death but does not modulate Bcl-2 or Bcl-x expression. Since Bcl-x expression is insufficient to ensure cell survival in the absence of IL-4, we specu ..."
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of growth factor. To characterize the IL-4-induced regulation of murine Bcl-3 expression, we cloned the promoter of this gene. Sequencing of the promoter showed no TATA box element but did reveal binding sites for AP1, AP1-like, and SP1 transcription factors. Retardation gels showed that IL-4 specifically
the Transcription Factor AP-1 Activity by Glucocorticoid Receptor
"... Inhibition of c-Jun/ATF2 phosphorylation, Trans-repression of c-Jun/c-Fos: Two modes of regulation of the transcription factor ..."
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Inhibition of c-Jun/ATF2 phosphorylation, Trans-repression of c-Jun/c-Fos: Two modes of regulation of the transcription factor
GM-CSF Increases AP-1 DNA Binding and Ref-1 Amounts in Human Alveolar Macrophages
"... Alveolar macrophages have been implicated in the pathogenesis of a number of acute and chronic lung disorders. A characteristic feature of many of the chronic lung diseases is that the types of macrophages in the lung change, and in most instances, the cells resemble monocyte-like cells. We have pre ..."
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previously shown that normal human alveolar macrophages have a decreased capacity to express protein kinase C (PKC)-induced DNA binding activity of the transcription factor activator protein (AP)-1 compared with monocytes. This decrease in AP-1 DNA binding appears to be due to a defect in redox regulation
References Subscriptions Permissions Email Alerts Corticotropin-Releasing Factor and the Urocortins Induce the Expression of TLR4 in Macrophages via Activation of the Transcription Factors PU.1 and AP-1
, 2013
"... This article cites 46 articles, 23 of which you can access for free at: ..."
Transcription factors that regulate monocyte/macrophage differentiation
- Journal of Leukocyte Biology,vol.63,no.4,pp
, 1998
"... differentiation ..."
The Transcription Factor PU.1 Is Involved in Macrophage Proliferation
"... PU.1 is a tissue-specific transcription factor that is expressed in cells of the hematopoietic lineage including macrophages, granulocytes, and B lymphocytes. Bone marrow-derived macrophages transfected with an antisense PU.1 expression construct or treated with antisense oligonucleotides showed a d ..."
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Cited by 13 (4 self)
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PU.1 is a tissue-specific transcription factor that is expressed in cells of the hematopoietic lineage including macrophages, granulocytes, and B lymphocytes. Bone marrow-derived macrophages transfected with an antisense PU.1 expression construct or treated with antisense oligonucleotides showed a
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