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Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite

by Metalloprotease Gp, Irazú Contreras, María Adelaida Gómez, Oliver Nguyen, Marina T. Shio, Robert W. Mcmaster, Martin Olivier
"... Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro-inflammatory cytokin ..."
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Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro

Expression of the peroxisome proliferator-activated receptor � (PPAR�) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

by Mercedes Ricote, Jannet T. Huang, John S. Welch, Christopher K. Glass - Proc. Natl. Acad. Sci. USA , 1998
"... (PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily to regula ..."
Abstract - Cited by 266 (7 self) - Add to MetaCart
(PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP-1

by Esteban S. Masuda, L Hiroshi Tokumitsu, L Akio Tsuboi, Joseph Shlomai , 1993
"... Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor. We have previously shown that a fragme ..."
Abstract - Cited by 13 (2 self) - Add to MetaCart
Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor. We have previously shown that a

Antioxidant and redox regulation of gene transcription

by Chandan K. Sen, Lester Packer - FASEB J , 1996
"... ABSTRACT Reactive oxygen species (ROS) are implicated in the pathogenesis of a wide variety of human diseases. Recent evidence suggests that at moderately high concentrations, certain forms of ROS such as 11202 may act as signal transduction messengers. To develop a better understanding of the exact ..."
Abstract - Cited by 89 (2 self) - Add to MetaCart
, nuclear factor (NF) KB and activator protein (AP)-1 have been identified to be regulated by the intracellular redox state. The regulation of gene expression by

Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors

by Angelita Rebollo, Laure Dumoutier, Jean-christophe Renauld, Angel Zaballos , 1999
"... We have analyzed the interleukin-4 (IL-4)-triggered mechanisms implicated in cell survival and show here that IL-4 deprivation induces apoptotic cell death but does not modulate Bcl-2 or Bcl-x expression. Since Bcl-x expression is insufficient to ensure cell survival in the absence of IL-4, we specu ..."
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of growth factor. To characterize the IL-4-induced regulation of murine Bcl-3 expression, we cloned the promoter of this gene. Sequencing of the promoter showed no TATA box element but did reveal binding sites for AP1, AP1-like, and SP1 transcription factors. Retardation gels showed that IL-4 specifically

the Transcription Factor AP-1 Activity by Glucocorticoid Receptor

by Forschungszentrum Karlsruhe, Wissenschaftliche Berichte, Phosphorylation Trans, S. Sekula, Forschungszentrum Karlsruhe, Wissenschaftliche Berichte, Sylwia Sekula
"... Inhibition of c-Jun/ATF2 phosphorylation, Trans-repression of c-Jun/c-Fos: Two modes of regulation of the transcription factor ..."
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Inhibition of c-Jun/ATF2 phosphorylation, Trans-repression of c-Jun/c-Fos: Two modes of regulation of the transcription factor

GM-CSF Increases AP-1 DNA Binding and Ref-1 Amounts in Human Alveolar Macrophages

by Dawn M. Flaherty, Martha M. Monick, A. Brent Carter, Michael W. Peterson, Gary W. Hunninghake
"... Alveolar macrophages have been implicated in the pathogenesis of a number of acute and chronic lung disorders. A characteristic feature of many of the chronic lung diseases is that the types of macrophages in the lung change, and in most instances, the cells resemble monocyte-like cells. We have pre ..."
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previously shown that normal human alveolar macrophages have a decreased capacity to express protein kinase C (PKC)-induced DNA binding activity of the transcription factor activator protein (AP)-1 compared with monocytes. This decrease in AP-1 DNA binding appears to be due to a defect in redox regulation

References Subscriptions Permissions Email Alerts Corticotropin-Releasing Factor and the Urocortins Induce the Expression of TLR4 in Macrophages via Activation of the Transcription Factors PU.1 and AP-1

by Christos Tsatsanis, Ariadne Androulidaki, Themis Alissafi, Ioannis Charalampopoulos, Erini Dermitzaki, Thierry Roger, Achille Gravanis, Andrew N. Margioris, Erini Dermitzaki, Thierry Roger, Achille Gravanis, Andrew N. Margioris , 2013
"... This article cites 46 articles, 23 of which you can access for free at: ..."
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This article cites 46 articles, 23 of which you can access for free at:

Transcription factors that regulate monocyte/macrophage differentiation

by Annabel F. Valledor, Francesc E. Borràs, Martin Cullell-young, Antonio Celada - Journal of Leukocyte Biology,vol.63,no.4,pp , 1998
"... differentiation ..."
Abstract - Cited by 20 (0 self) - Add to MetaCart
differentiation

The Transcription Factor PU.1 Is Involved in Macrophage Proliferation

by Antonio Celada, Francesc E. Borr~ts, Concepci Soler, Jorge Lloberas, Michael Klemsz, Charles Van Beverenfl, Scott Mckercher, Richard A. Makill
"... PU.1 is a tissue-specific transcription factor that is expressed in cells of the hematopoietic lineage including macrophages, granulocytes, and B lymphocytes. Bone marrow-derived macrophages transfected with an antisense PU.1 expression construct or treated with antisense oligonucleotides showed a d ..."
Abstract - Cited by 13 (4 self) - Add to MetaCart
PU.1 is a tissue-specific transcription factor that is expressed in cells of the hematopoietic lineage including macrophages, granulocytes, and B lymphocytes. Bone marrow-derived macrophages transfected with an antisense PU.1 expression construct or treated with antisense oligonucleotides showed a
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