Map interpretation remains a critical step in solving the structure of a macromolecule. Errors introduced at this early stage may persist throughout crystallo-graphic refinement and result in an incorrect struc-ture. The normally quoted crystallographic residual is often a poor description

), a struc-ture of purposes (called the intentional structure), and the state of focus of attention (called the attentional state). The linguistic structure consists of segments of the discourse into which the utter-ances naturally aggregate. The intentional structure captures the discourse

Freebase is a practical, scalable tuple database used to struc-ture general human knowledge. The data in Freebase is collaboratively created, structured, and maintained. Free-base currently contains more than 125,000,000 tuples, more than 4000 types, and more than 7000 properties. Public read

, as given in (2). (2) Lexicalism: words are created in the Lexicon, by proc-esses distinct from the syntactic processes of putting mor-phemes/words together. Some phonology and some struc-ture/meaning connections are derived in the lexicon, while other

investigations on the switching dynamics of TMR struc-

in HS macromolecular structures associated with solution chemistry may be caused by the protonation, deprotonation, and metal complex-ation of HS functional groups. The noted dif-ferences between the macromolecular struc-tures of HSs of different origin are a reflection of the low solubility

Amphetamine remains the chemist's "Cinderella " molecule. No other compound has di-played such a plethora of pharmacological, biochemical, and physiological effects,... nor have many other molecules served as so versatile a starting base for the synthetic elaboration of a host of novel therapeutic agents. (Biel alld Bopp, 1978; This description of amphetamine remain as true today as it was in 1978. As a imple molecule of only nine carbon atoms with one chiral center, amphetamine is dwarfed by the structural complexity of most other classes of drugs. Nevertheless, the pharmacophoric template, an aromatic ring separated by two carbon atoms from a basic nitrogen, is a motif that occurs repeatedly in many classes of biolog-icaUy active molecules. Perhaps a remarkable charactersitic of amphetamine is that relatively minor structural changes can alter the pharmacology of the molecule

crude wire-model coordinates of a small protein is described and evaluated. Introduction Until recently the refinement of macromolecular struc- tures against X-ray diffraction data was a laborious process, involving many comparisons of a model with a difference map, followed by manual

and of chlorine-related trace gases near 40 km provide evidence that gas phase chemistry has indeed currently depleted about 10 % of the stratospheric ozone there as predicted, and the vertical and horizontal struc-tures of this depletion are fingerprints for that process. More striking changes are observed each

Noam Chomsky told the following about the origin of his first book, Syntactic Structures: In 1956, at the suggestion of Morris Halle, I showed some of my lecture notes for an undergraduate course at MIT to Cornelis van Schooneveld, the editor of the Janua Linguarum series of Mouton and he offered to publish them. A slightly revised version appeared in 1957, under the title Syntactic Structures (SS). (Chomsky 1975:3) More recently, in an interview given in December 1996 at Maceió, Brasil, he presented a much more detached view on this historic event: At the time Mouton was publishing just about anything, so they decided they’d publish it along with a thousand other worthless things that were coming out. That’s the story of Syntactic Structures: course notes for undergraduate science students published by accident in Europe. (Dillinger & Palácio 1997:162-163) The historiographer seriously interested in the rise and the fall of the generative paradigm might wish to know when in fact the release of Syntactic Structures took place. An answer to this question was given by Murray in two recent articles (1999a, 1999b:264-265). These papers also deal with the publication date of Robert B. Lees ’ (1922-1996) well-known 1957 review article on Syntactic